Functional Expression of HGF and HGF Receptor/c-met in Adult Human Mesenchymal Stem Cells Suggests a Role in Cell Mobilization, Tissue Repair, and Wound Healing

Stem Cells ◽  
2004 ◽  
Vol 22 (3) ◽  
pp. 405-414 ◽  
Author(s):  
Sabine Neuss ◽  
Eva Becher ◽  
Michael Wöltje ◽  
Lothar Tietze ◽  
Willi Jahnen-Dechent
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Tissue Repair ◽  
Human Mesenchymal Stem Cells ◽  
Functional Expression ◽  
Adult Human ◽  
Cell Mobilization

scholarly journals Chronic senescent human mesenchymal stem cells as possible contributor to the wound healing disorder after exposure to the alkylating agent sulfur mustard

2021 ◽  
Vol 95 (2) ◽  
pp. 727-747
Author(s):  
Simone Rothmiller ◽  
Niklas Jäger ◽  
Nicole Meier ◽  
Thimo Meyer ◽  
Adrian Neu ◽  
...  
Keyword(s):  
Stem Cells ◽  
Wound Healing ◽  
Mesenchymal Stem Cells ◽  
Alkylating Agent ◽  
Chronic Wounds ◽  
Sulfur Mustard ◽  
Morphological Changes ◽  
Human Mesenchymal Stem Cells ◽  
Age Related

AbstractWound healing is a complex process, and disturbance of even a single mechanism can result in chronic ulcers developing after exposure to the alkylating agent sulfur mustard (SM). A possible contributor may be SM-induced chronic senescent mesenchymal stem cells (MSCs), unable to fulfil their regenerative role, by persisting over long time periods and creating a proinflammatory microenvironment. Here we show that senescence induction in human bone marrow derived MSCs was time- and concentration-dependent, and chronic senescence could be verified 3 weeks after exposure to between 10 and 40 µM SM. Morphological changes, reduced clonogenic and migration potential, longer scratch closure times, differences in senescence, motility and DNA damage response associated genes as well as increased levels of proinflammatory cytokines were revealed. Selective removal of these cells by senolytic drugs, in which ABT-263 showed initial potential in vitro, opens the possibility for an innovative treatment strategy for chronic wounds, but also tumors and age-related diseases.

Regulation of adult human mesenchymal stem cells into osteogenic and chondrogenic lineages by different bioreactor systems

2009 ◽  
Vol 88A (4) ◽  
pp. 935-946 ◽  
Author(s):  
Tzu-Wei Wang ◽  
Hsi-Chin Wu ◽  
Hsin-Yen Wang ◽  
Feng-Huei Lin ◽  
Jui-Sheng Sun
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Adult Human

Effects of a bone-like mineral film on phenotype of adult human mesenchymal stem cells in vitro

Biomaterials ◽  
2005 ◽  
Vol 26 (3) ◽  
pp. 303-310 ◽  
Author(s):  
W MURPHY ◽  
S HSIONG ◽  
T RICHARDSON ◽  
C SIMMONS ◽  
D MOONEY
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Adult Human

scholarly journals Specification of a Dopaminergic Phenotype from Adult Human Mesenchymal Stem Cells

Stem Cells ◽  
2007 ◽  
Vol 25 (11) ◽  
pp. 2797-2808 ◽  
Author(s):  
Katarzyna A. Trzaska ◽  
Eldo V. Kuzhikandathil ◽  
Pranela Rameshwar
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Adult Human
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