Mesenchymal stem cells derived‐exosomes as a new therapeutic strategy for acute soft tissue injury

2020 ◽  
Author(s):  
Hongchang Yang ◽  
Jing Zhou ◽  
Hongyao Pan ◽  
Wei Wei ◽  
Run Gao ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Soft Tissue ◽  
Therapeutic Strategy ◽  
Tissue Injury ◽  
Soft Tissue Injury

scholarly journals IFATS Collection: Human Adipose-Derived Stem Cells Seeded on a Silk Fibroin-Chitosan Scaffold Enhance Wound Repair in a Murine Soft Tissue Injury Model

Stem Cells ◽  
2009 ◽  
Vol 27 (1) ◽  
pp. 250-258 ◽  
Author(s):  
Andrew M. Altman ◽  
Yasheng Yan ◽  
Nadine Matthias ◽  
Xiaowen Bai ◽  
Carmen Rios ◽  
...  
Keyword(s):  
Stem Cells ◽  
Soft Tissue ◽  
Silk Fibroin ◽  
Wound Repair ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Adipose Derived Stem Cells ◽  
Chitosan Scaffold ◽  
Injury Model

Auto seat restraint soft-tissue injury

1987 ◽  
Vol 148 (2) ◽  
pp. 458-458 ◽  
Author(s):  
DR Pennes ◽  
WA Phillips
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury

scholarly journals Protective Effects of a Hyaluronan-Binding Peptide (P15-1) on Mesenchymal Stem Cells in an Inflammatory Environment

2021 ◽  
Vol 22 (13) ◽  
pp. 7058
Author(s):  
Thorsten Kirsch ◽  
Fenglin Zhang ◽  
Olivia Braender-Carr ◽  
Mary K. Cowman
Keyword(s):  
Stem Cells ◽  
Bone Marrow ◽  
Mesenchymal Stem Cells ◽  
Chondrogenic Differentiation ◽  
Therapeutic Strategy ◽  
Cartilage Defects ◽  
Mrna Levels ◽  
Protective Effects ◽  
Human Bmscs ◽  
Hyaluronan Binding

Mesenchymal stem cells (MSCs) obtained from various sources, including bone marrow, have been proposed as a therapeutic strategy for the improvement of tissue repair/regeneration, including the repair of cartilage defects or lesions. Often the highly inflammatory environment after injury or during diseases, however, greatly diminishes the therapeutic and reparative effectiveness of MSCs. Therefore, the identification of novel factors that can protect MSCs against an inflammatory environment may enhance the effectiveness of these cells in repairing tissues, such as articular cartilage. In this study, we investigated whether a peptide (P15-1) that binds to hyaluronan (HA), a major component of the extracellular matrix of cartilage, protects bone-marrow-derived MSCs (BMSCs) in an inflammatory environment. The results showed that P15-1 reduced the mRNA levels of catabolic and inflammatory markers in interleukin-1beta (IL-1β)-treated human BMSCs. In addition, P15-1 enhanced the attachment of BMSCs to HA-coated tissue culture dishes and stimulated the chondrogenic differentiation of the multipotential murine C3H/10T1/2 MSC line in a micromass culture. In conclusion, our findings suggest that P15-1 may increase the capacity of BMSCs to repair cartilage via the protection of these cells in an inflammatory environment and the stimulation of their attachment to an HA-containing matrix and chondrogenic differentiation.

scholarly journals Intercellular mitochondria trafficking highlighting the dual role of mesenchymal stem cells as both sensors and rescuers of tissue injury

Cell Cycle ◽  
2018 ◽  
Vol 17 (6) ◽  
pp. 712-721 ◽  
Author(s):  
Anne-Marie Rodriguez ◽  
Jean Nakhle ◽  
Emmanuel Griessinger ◽  
Marie-Luce Vignais
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Tissue Injury ◽  
Dual Role

Soft tissue injury associated with intravenous phenytoin in a neonate

1994 ◽  
Vol 83 (11) ◽  
pp. 1218-1219 ◽  
Author(s):  
N. Sharief ◽  
C. Goonasekera
Keyword(s):  
Soft Tissue ◽  
Tissue Injury ◽  
Soft Tissue Injury

Establishment of soft-tissue-injury model of high-voltage electrical burn and observation of its pathological changes

Burns ◽  
2009 ◽  
Vol 35 (8) ◽  
pp. 1158-1164 ◽  
Author(s):  
Chai Jia-ke ◽  
Li Li-gen ◽  
Gao Quan-wen ◽  
Shen Xiao-peng ◽  
Zhang Hai-jun ◽  
...  
Keyword(s):  
Soft Tissue ◽  
High Voltage ◽  
Tissue Injury ◽  
Soft Tissue Injury ◽  
Pathological Changes ◽  
Injury Model
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