scholarly journals Human Mesenchymal Stem Cells Promote Survival of T Cells in a Quiescent State

Stem Cells ◽  
2007 ◽  
Vol 25 (7) ◽  
pp. 1753-1760 ◽  
Author(s):  
Federica Benvenuto ◽  
Stefania Ferrari ◽  
Ezio Gerdoni ◽  
Francesca Gualandi ◽  
Francesco Frassoni ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Human Mesenchymal Stem Cells ◽  
Quiescent State

scholarly journals Effect of Human Mesenchymal Stem Cells on Xenogeneic T and B Cells Isolated from Lupus-Prone MRL.Faslpr Mice

2020 ◽  
Vol 2020 ◽  
pp. 1-10
Author(s):  
Hong Kyung Lee ◽  
Eun Young Kim ◽  
Hyung Sook Kim ◽  
Eun Jae Park ◽  
Hye Jin Lee ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
B Cells ◽  
Lupus Erythematosus ◽  
Human Mesenchymal Stem Cells ◽  
Preclinical Studies ◽  
Dependent Manner ◽  
T And B Cells

Systemic lupus erythematosus (SLE) is an autoimmune disease, which is characterized by hyperactivation of T and B cells. Human mesenchymal stem cells (hMSCs) ameliorate the progression of SLE in preclinical studies using lupus-prone MRL.Faslpr mice. However, whether hMSCs inhibit the functions of xenogeneic mouse T and B cells is not clear. To address this issue, we examined the in vitro effects of hMSCs on T and B cells isolated from MRL.Faslpr mice. Naïve hMSCs inhibited the functions of T cells but not B cells. hMSCs preconditioned with IFN-γ (i) inhibited the proliferation of and IgM production by B cells, (ii) attracted B cells for cell–cell interactions in a CXCL10-dependent manner, and (iii) inhibited B cells by producing indoleamine 2,3-dioxygenase. In summary, our data demonstrate that hMSCs exert therapeutic activity in mice in three steps: first, naïve hMSCs inhibit the functions of T cells, hMSCs are then activated by IFN-γ, and finally, they inhibit B cells.

Human Mesenchymal Stem Cells Are Susceptible to Lysis by CD8+ T Cells and NK Cells

2011 ◽  
Vol 20 (10) ◽  
pp. 1547-1559 ◽  
Author(s):  
Meindert J. Crop ◽  
Sander S. Korevaar ◽  
Ronella De Kuiper ◽  
Jan N. M. Ijzermans ◽  
Nicole M. Van Besouw ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Nk Cells ◽  
Cd8 T Cells ◽  
Human Mesenchymal Stem Cells

Human mesenchymal stem cells alter antigen-presenting cell maturation and induce T-cell unresponsiveness

Blood ◽  
2005 ◽  
Vol 105 (5) ◽  
pp. 2214-2219 ◽  
Author(s):  
Shaul Beyth ◽  
Zipora Borovsky ◽  
Dror Mevorach ◽  
Meir Liebergall ◽  
Zulma Gazit ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
T Cell ◽  
Human Mesenchymal Stem Cells ◽  
Cell Responses ◽  
Dependent Inhibition ◽  
Dose Dependent Inhibition ◽  
Antigen Presenting ◽  
Dose Dependent

AbstractInfusion of either embryonic or mesenchymal stem cells prolongs the survival of organ transplants derived from stem cell donors and prevents graft-versus-host-disease (GVHD). An in-depth mechanistic understanding of this tolerization phenomenon could lead to novel cell-based therapies for transplantation. Here we demonstrate that while human mesenchymal stem cells (hMSCs) can promote superantigen-induced activation of purified T cells, addition of antigen-presenting cells (APCs; either monocytes or dendritic cells) to the cultures inhibits the T-cell responses. This contact- and dose-dependent inhibition is accompanied by secretion of large quantities of interleukin (IL)–10 and aberrant APC maturation, which can be partially overridden by the addition of factors that promote APC maturation (ie, lipopolysaccharide [LPS] or anti-CD40 monoclonal antibody [mAb]). Thus, our data support an immunoregulatory mechanism wherein hMSCs inhibit T cells indirectly by contact-dependent induction of regulatory APCs with T-cell–suppressive properties. Our data may reveal a physiologic phenomenon whereby the development of a distinct APC population is regulated by the tissue's cellular microenvironment.

scholarly journals Human mesenchymal stem cells shift CD8+ T cells towards a suppressive phenotype by inducing tolerogenic monocytes

2012 ◽  
Vol 125 (19) ◽  
pp. 4640-4650 ◽  
Author(s):  
I. Hof-Nahor ◽  
L. Leshansky ◽  
S. Shivtiel ◽  
L. Eldor ◽  
D. Aberdam ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Cd8 T Cells ◽  
Human Mesenchymal Stem Cells ◽  
Suppressive Phenotype

scholarly journals Reciprocal Interactions Between Human Mesenchymal Stem Cells and γδ T Cells Or Invariant Natural Killer T Cells

Stem Cells ◽  
2009 ◽  
Vol 27 (3) ◽  
pp. 693-702 ◽  
Author(s):  
Ignazia Prigione ◽  
Federica Benvenuto ◽  
Paola Bocca ◽  
Luca Battistini ◽  
Antonio Uccelli ◽  
...  
Keyword(s):  
Stem Cells ◽  
T Cells ◽  
Mesenchymal Stem Cells ◽  
Natural Killer ◽  
Human Mesenchymal Stem Cells ◽  
Γδ T Cells ◽  
Natural Killer T Cells ◽  
Reciprocal Interactions ◽  
Killer T Cells ◽  
Invariant Natural Killer
Sign in / Sign up

Export Citation Format

Share Document