scholarly journals Fluorophore-Conjugated Iron Oxide Nanoparticle Labeling and Analysis of Engrafting Human Hematopoietic Stem Cells

Stem Cells ◽  
2008 ◽  
Vol 26 (2) ◽  
pp. 517-524 ◽  
Author(s):  
Dustin J. Maxwell ◽  
Jesper Bonde ◽  
David A. Hess ◽  
Sarah A. Hohm ◽  
Ryan Lahey ◽  
...  
Keyword(s):  
Stem Cells ◽  
Iron Oxide ◽  
Hematopoietic Stem Cells ◽  
Iron Oxide Nanoparticle ◽  
Hematopoietic Stem ◽  
Oxide Nanoparticle

scholarly journals Targeted Delivery of Iron Oxide Nanoparticle-Loaded Human Embryonic Stem Cell-Derived Spherical Neural Masses for Treating Intracerebral Hemorrhage

2020 ◽  
Vol 21 (10) ◽  
pp. 3658
Author(s):  
Min Kyoung Kang ◽  
Tae Jung Kim ◽  
Young-Ju Kim ◽  
Lamie Kang ◽  
Jonghoon Kim ◽  
...  
Keyword(s):  
Magnetic Field ◽  
Stem Cells ◽  
Stem Cell ◽  
Iron Oxide ◽  
External Magnetic Field ◽  
Targeted Delivery ◽  
Human Embryonic Stem Cell ◽  
Embryonic Stem ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle

This study evaluated the potential of iron oxide nanoparticle-loaded human embryonic stem cell (ESC)-derived spherical neural masses (SNMs) to improve the transportation of stem cells to the brain, ameliorate brain damage from intracerebral hemorrhage (ICH), and recover the functional status after ICH under an external magnetic field of a magnet attached to a helmet. At 24 h after induction of ICH, rats were randomly separated into three experimental groups: ICH with injection of phosphate-buffered saline (PBS group), ICH with intravenous injection of magnetosome-like ferrimagnetic iron oxide nanocubes (FION)-labeled SNMs (SNMs* group), and ICH with intravenous injection of FION-labeled SNMs followed by three days of external magnetic field exposure for targeted delivery by a magnet-embedded helmet (SNMs*+Helmet group). On day 3 after ICH induction, an increased Prussian blue-stained area and decreased swelling volume were observed in the SNMs*+Helmet group compared with that of the other groups. A significantly decreased recruitment of macrophages and neutrophils and a downregulation of pro-inflammatory cytokines followed by improved neurological function three days after ICH were observed in the SNMs*+Helmet group. Hemispheric atrophy at six weeks after ICH was significantly decreased in the SNMs*+Helmet group compared with that of the PBS group. In conclusion, we have developed a targeted delivery system using FION tagged to stem cells and a magnet-embedded helmet. The targeted delivery of SNMs might have the potential for developing novel therapeutic strategies for ICH.

scholarly journals Tracking Mesenchymal Stem Cells with Iron Oxide Nanoparticle Loaded Poly(lactide-co-glycolide) Microparticles

Nano Letters ◽  
2012 ◽  
Vol 12 (8) ◽  
pp. 4131-4139 ◽  
Author(s):  
Chenjie Xu ◽  
David Miranda-Nieves ◽  
James A. Ankrum ◽  
Mads Emil Matthiesen ◽  
Joseph A. Phillips ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Iron Oxide ◽  
Iron Oxide Nanoparticle ◽  
Oxide Nanoparticle
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