The Role of Exogenous Fibroblast Growth Factor-2 on the Reprogramming of Primordial Germ Cells into Pluripotent Stem Cells

Stem Cells ◽  
2006 ◽  
Vol 24 (6) ◽  
pp. 1441-1449 ◽  
Author(s):  
Gabriela Durcova-Hills ◽  
Ian R. Adams ◽  
Sheila C. Barton ◽  
M. Azim Surani ◽  
Anne McLaren
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Germ Cells ◽  
Pluripotent Stem Cells ◽  
Primordial Germ Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth

scholarly journals Expression and Potential Role of Fibroblast Growth Factor 2 and Its Receptors in Human Embryonic Stem Cells

Stem Cells ◽  
2005 ◽  
Vol 23 (8) ◽  
pp. 1200-1211 ◽  
Author(s):  
Petr Dvorak ◽  
Dana Dvorakova ◽  
Stanislava Koskova ◽  
Martina Vodinska ◽  
Miroslava Najvirtova ◽  
...  
Keyword(s):  
Stem Cells ◽  
Embryonic Stem Cells ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Human Embryonic Stem Cells ◽  
Potential Role ◽  
Embryonic Stem ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth

scholarly journals Glypican-1 drives unconventional secretion of Fibroblast Growth Factor 2

2021 ◽  
Author(s):  
Carola Sparn ◽  
Eleni Dimou ◽  
Annalena Meyer ◽  
Roberto Saleppico ◽  
Sabine Wegehingel ◽  
...  
Keyword(s):  
Growth Factor ◽  
Heparan Sulfate ◽  
Fibroblast Growth Factor ◽  
Fibroblast Growth Factor 2 ◽  
Structural Basis ◽  
Limiting Factor ◽  
Fibroblast Growth ◽  
Unconventional Secretion ◽  
Rate Limiting

Fibroblast Growth Factor 2 (FGF2) is a tumor cell survival factor that is transported into the extracellular space by an unconventional secretory mechanism. Cell surface heparan sulfate proteoglycans are known to play an essential role in this process. Unexpectedly, we found that among the diverse sub-classes consisting of syndecans, perlecans, glypicans and others, Glypican-1 (GPC1) is both the principle and rate-limiting factor that drives unconventional secretion of FGF2. By contrast, we demonstrate GPC1 to be dispensable for FGF2 signaling into cells. We provide first insights into the structural basis for GPC1-dependent FGF2 secretion, identifying disaccharides with N-linked sulfate groups to be enriched in the heparan sulfate chains of GPC1 to which FGF2 binds with high affinity. Our findings have broad implications for the role of GPC1 as a key molecule in tumor progression.

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