scholarly journals Tyrosine Kinase Expressed in Hepatocellular Carcinoma, TEC, Controls Pluripotency and Early Cell Fate Decisions of Human Pluripotent Stem Cells via Regulation of Fibroblast Growth Factor-2 Secretion

Stem Cells ◽  
2017 ◽  
Vol 35 (9) ◽  
pp. 2050-2059 ◽  
Author(s):  
Tereza Vanova ◽  
Zaneta Konecna ◽  
Zuzana Zbonakova ◽  
Giuseppe La Venuta ◽  
Karolina Zoufalova ◽  
...  
Keyword(s):  
Hepatocellular Carcinoma ◽  
Stem Cells ◽  
Growth Factor ◽  
Tyrosine Kinase ◽  
Fibroblast Growth Factor ◽  
Cell Fate ◽  
Pluripotent Stem Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth ◽  
Cell Fate Decisions

The Role of Exogenous Fibroblast Growth Factor-2 on the Reprogramming of Primordial Germ Cells into Pluripotent Stem Cells

Stem Cells ◽  
2006 ◽  
Vol 24 (6) ◽  
pp. 1441-1449 ◽  
Author(s):  
Gabriela Durcova-Hills ◽  
Ian R. Adams ◽  
Sheila C. Barton ◽  
M. Azim Surani ◽  
Anne McLaren
Keyword(s):  
Stem Cells ◽  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Germ Cells ◽  
Pluripotent Stem Cells ◽  
Primordial Germ Cells ◽  
Fibroblast Growth Factor 2 ◽  
Fibroblast Growth

A role for the fibroblast growth factor receptor in cell fate decisions in the developing vertebrate retina

Development ◽  
1998 ◽  
Vol 125 (20) ◽  
pp. 3967-3975 ◽  
Author(s):  
S. McFarlane ◽  
M.E. Zuber ◽  
C.E. Holt
Keyword(s):  
Growth Factor ◽  
Fibroblast Growth Factor ◽  
Cell Fate ◽  
Fibroblast Growth Factor Receptor ◽  
Growth Factor Receptor ◽  
Retinal Cell ◽  
Fibroblast Growth ◽  
Cell Fate Decisions ◽  
Mutant Receptor ◽  
Vertebrate Retina

The mature vertebrate retina contains seven major cell types that develop from an apparently homogenous population of precursor cells. Clonal analyses have suggested that environmental influences play a major role in specifying retinal cell identity. Fibroblast growth factor-2 is present in the developing retina and regulates the survival, proliferation and differentiation of developing retinal cells in culture. Here we have tested whether fibroblast growth factor receptor signaling biases retinal cell fate decisions in vivo. Fibroblast growth factor receptors were inhibited in retinal precursors in Xenopus embryos by expressing a dominant negative form of the receptor, XFD. Dorsal animal blastomeres that give rise to the retina were injected with cDNA expression constructs for XFD and a control non-functional mutant receptor, D48, and the cell fates of transgene-expressing cells in the mature retina determined. Fibroblast growth factor receptor blockade results in almost a 50% loss of photoreceptors and amacrine cells, and a concurrent 3.5-fold increase in Muller glia, suggesting a shift towards a Muller cell fate in the absence of a fibroblast growth factor receptor signal. Inhibition of non-fibroblast-growth-factor-mediated receptor signaling with a third mutant receptor, HAVO, alters cell fate in an opposite manner. These results suggest that it is the balance of fibroblast growth factor and non-fibroblast growth factor ligand signals that influences retinal cell genesis.

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