Successful Stem Cell Therapy Using Umbilical Cord Blood-Derived Multipotent Stem Cells for Buerger's Disease and Ischemic Limb Disease Animal Model

Stem Cells ◽  
2006 ◽  
Vol 24 (6) ◽  
pp. 1620-1626 ◽  
Author(s):  
Sung-Whan Kim ◽  
Hoon Han ◽  
Gue-Tae Chae ◽  
Sung-Hoon Lee ◽  
Sun Bo ◽  
...  
Keyword(s):  
Stem Cells ◽  
Animal Model ◽  
Stem Cell ◽  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Stem Cell Therapy ◽  
Umbilical Cord Blood ◽  
Multipotent Stem Cells ◽  
Ischemic Limb

scholarly journals Cross-Culture Online Knowledge Validation and the Exclusive Practice of Stem Cell Therapy

2021 ◽  
Vol 29 (2) ◽  
pp. 1-28
Author(s):  
Abrar Al-Hasan ◽  
Jiban Khuntia ◽  
Dobin Yim
Keyword(s):  
Stem Cell ◽  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Stem Cell Therapy ◽  
Umbilical Cord Blood ◽  
Theoretical Perspective ◽  
The Internet ◽  
Cross Culture ◽  
Knowledge Validation

Increasingly, people are turning to the internet to access health information despite reports that sites vary in terms of their quality, especially when the health practice is emerging or exclusive, such as stem cell and umbilical cord blood therapy. Given the controversy, patients have to depend on available sources to validate their knowledge prior to going for these practices as treatments. This study explores how the internet supports the spread of stem cell therapy practices, viewing it from a knowledge validation theoretical perspective. The study posits hypotheses differentiating digital and human sources, trust in the media source, and exploratory and verification sources on knowledge validation for exclusive practices. Primary survey data was collected from the US and Kuwait. Key findings suggest that knowledge verification and trust in the internet influences knowledge conversion and the practice decision of patients for less practice-oriented knowledge, and this effect is higher for Kuwait than USA, and more so for stem cell than umbilical cord blood practice.

Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges

2019 ◽  
Vol 98 (5) ◽  
pp. 815-825 ◽  
Author(s):  
Xirui Peng ◽  
Juan Song ◽  
Bingbing Li ◽  
Changlian Zhu ◽  
Xiaoyang Wang
Keyword(s):  
Stem Cell ◽  
Brain Injury ◽  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Stem Cell Therapy ◽  
Umbilical Cord Blood ◽  
Blood Stem Cell ◽  
Cord Blood Stem Cell ◽  
Premature Brain

scholarly journals Very Small Embryonic-Like Stem Cells Purified from Umbilical Cord Blood Lack Stem Cell Characteristics

PLoS ONE ◽  
2012 ◽  
Vol 7 (4) ◽  
pp. e34899 ◽  
Author(s):  
Ralitza Danova-Alt ◽  
Andreas Heider ◽  
Dietmar Egger ◽  
Michael Cross ◽  
Rüdiger Alt
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood

scholarly journals UMBILICAL CORD BLOOD BANKING IN THE WORLDWIDE HEMATOPOIETIC STEM CELL TRANSPLANTATION SYSTEM: PERSPECTIVES FOR UKRAINE

2017 ◽  
Vol 39 (3) ◽  
pp. 164-170 ◽  
Author(s):  
T O Kalynychenko
Keyword(s):  
Stem Cells ◽  
Stem Cell ◽  
Hematopoietic Stem Cell Transplantation ◽  
Stem Cell Transplantation ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Hematopoietic Stem ◽  
Blood Banks ◽  
Cord Blood Banks

Significant progress in the promotion of procedural technologies associated with the transplantation of hematopoietic stem cells caused a rapid increase in activity. The exchange of hematopoietic stem cells for unrelated donor transplantations is now much easier due to the relevant international professional structures and organizations established to support cooperation and standard setting, as well as rules for the functioning of both national donor registries and cord blood banks. These processes are increasing every year and are contributing to the outpacing rates of development in this area. Products within their country should be regulated by the competent government authorities. This study analyzes the work of international and national levels of support for transplantation activity in the field of unrelated hematopoietic stem cell transplantation, the standardization order of technologies, as well as data that justify the need to create a network of donated umbilical cord blood banks in Ukraine as a factor in the development of allogeneic transplantation. This will promote the accessibility of international standards for the treatment of serious diseases for Ukrainian citizens.

scholarly journals A Small-Sized Population of Human Umbilical Cord Blood-Derived Mesenchymal Stem Cells Shows High Stemness Properties and Therapeutic Benefit

2020 ◽  
Vol 2020 ◽  
pp. 1-17 ◽  
Author(s):  
Miyeon Kim ◽  
Yun Kyung Bae ◽  
Soyoun Um ◽  
Ji Hye Kwon ◽  
Gee-Hye Kim ◽  
...  
Keyword(s):  
Stem Cells ◽  
Mesenchymal Stem Cells ◽  
Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Surface Proteins ◽  
Lung Damage ◽  
Human Umbilical Cord Blood ◽  
Human Umbilical Cord

Mesenchymal stem cells (MSCs) represent a promising means to promote tissue regeneration. However, the heterogeneity of MSCs impedes their use for regenerative medicine. Further investigation of this phenotype is required to develop cell therapies with improved clinical efficacy. Here, a small-sized population of human umbilical cord blood-derived MSCs (UCB-MSCs) was isolated using a filter and centrifuge system to analyze its stem cell characteristics. Consequently, this population showed higher cell growth and lower senescence. Additionally, it exhibited diverse stem cell properties including differentiation, stemness, and adhesion, as compared to those of the population before isolation. Using cell surface protein array or sorting analysis, both EGFR and CD49f were identified as markers associated with the small-sized population. Accordingly, suppression of these surface proteins abolished the superior characteristics of this population. Moreover, compared to that with large or nonisolated populations, the small-sized population showed greater therapeutic efficacy by promoting the engraftment potential of infused cells and reducing lung damage in an emphysema mouse model. Therefore, the isolation of this small-sized population of UCB-MSCs could be a simple and effective way to enhance the efficacy of cell therapy.

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