Umbilical cord blood stem cell therapy in premature brain injury: Opportunities and challenges

2019 ◽  
Vol 98 (5) ◽  
pp. 815-825 ◽  
Author(s):  
Xirui Peng ◽  
Juan Song ◽  
Bingbing Li ◽  
Changlian Zhu ◽  
Xiaoyang Wang
Keyword(s):  
Stem Cell ◽  
Brain Injury ◽  
Cell Therapy ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Stem Cell Therapy ◽  
Umbilical Cord Blood ◽  
Blood Stem Cell ◽  
Cord Blood Stem Cell ◽  
Premature Brain

scholarly journals Neurovascular effects of umbilical cord blood-derived stem cells in growth-restricted newborn lambs

2020 ◽  
Vol 11 (1) ◽  
Author(s):  
Atul Malhotra ◽  
Margie Castillo-Melendez ◽  
Beth J. Allison ◽  
Amy E. Sutherland ◽  
Ilias Nitsos ◽  
...  
Keyword(s):  
Stem Cell ◽  
Brain Injury ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Neurovascular Unit ◽  
Blood Stem Cell ◽  
Endothelial Cell Proliferation ◽  
Arterial Blood ◽  
Cord Blood Stem Cell

Abstract Background Neonatal ventilation exacerbates brain injury in lambs with fetal growth restriction (FGR), characterized by neuroinflammation and reduced blood-brain barrier integrity, which is normally maintained by the neurovascular unit. We examined whether umbilical cord blood stem cell (UCBC) treatment stabilized the neurovascular unit and reduced brain injury in preterm ventilated FGR lambs. Methods Surgery was performed in twin-bearing pregnant ewes at 88 days’ gestation to induce FGR in one fetus. At 127 days, FGR and appropriate for gestational age (AGA) lambs were delivered, carotid artery flow probes and umbilical lines inserted, lambs intubated and commenced on gentle ventilation. Allogeneic ovine UCBCs (25 × 106 cells/kg) were administered intravenously to lambs at 1 h of life. Lambs were ventilated for 24 h and then euthanized. Results FGR (n = 6) and FGR+UCBC (n = 6) lambs were growth restricted compared to AGA (n = 6) and AGA+UCBC (n = 6) lambs (combined weight, FGR 2.3 ± 0.4 vs. AGA 3.0 ± 0.3 kg; p = 0.0002). UCBC therapy did not alter mean arterial blood pressure or carotid blood flow but decreased cerebrovascular resistance in FGR+UCBC lambs. Circulating TNF-α cytokine levels were lower in FGR+UCBC vs. FGR lambs (p < 0.05). Brain histopathology showed decreased neuroinflammation and oxidative stress, increased endothelial cell proliferation, pericyte stability, and greater integrity of the neurovascular unit in FGR+UCBC vs. FGR lambs. Conclusions Umbilical cord blood stem cell therapy mitigates perinatal brain injury due to FGR and ventilation, and the neuroprotective benefits may be mediated by stabilization of the neurovascular unit.

The impact of intrapartum factors on umbilical cord blood stem cell banking

2003 ◽  
Vol 31 (4) ◽  
Author(s):  
U. Aufderhaar ◽  
W. Holzgreve ◽  
E. Danzer ◽  
A. Tichelli ◽  
C. Troeger ◽  
...  
Keyword(s):  
Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Stem Cell ◽  
Cord Blood Stem Cell ◽  
Cell Banking ◽  
Stem Cell Banking ◽  
The Impact ◽  
Intrapartum Factors

scholarly journals Successful umbilical cord blood stem cell transplantation in a child with WHIM syndrome

2010 ◽  
Vol 84 (3) ◽  
pp. 274-275 ◽  
Author(s):  
Gergely Kriván ◽  
Melinda Erdős ◽  
Krisztián Kállay ◽  
Gábor Benyó ◽  
Ágnes Tóth ◽  
...  
Keyword(s):  
Stem Cell ◽  
Stem Cell Transplantation ◽  
Cord Blood ◽  
Cell Transplantation ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
Blood Stem Cell ◽  
Whim Syndrome ◽  
Cord Blood Stem Cell ◽  
Blood Stem Cell Transplantation

Factors affecting umbilical cord blood stem cell suitability for transplantation in an in utero collection program

Transfusion ◽  
2013 ◽  
Vol 54 (3) ◽  
pp. 545-549 ◽  
Author(s):  
Christine L. Keersmaekers ◽  
Brian A. Mason ◽  
Jan Keersmaekers ◽  
Matthew Ponzini ◽  
Ryan A. Mlynarek
Keyword(s):  
Stem Cell ◽  
Cord Blood ◽  
Umbilical Cord ◽  
Umbilical Cord Blood ◽  
In Utero ◽  
Blood Stem Cell ◽  
Factors Affecting ◽  
Cord Blood Stem Cell ◽  
Collection Program
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