scholarly journals Leridistim, a Chimeric Dual G-CSF and IL-3 Receptor Agonist, Enhances Multilineage Hematopoietic Recovery in a Nonhuman Primate Model of Radiation-Induced Myelosuppression: Effect of Schedule, Dose, and Route of Administration

Stem Cells ◽  
2001 ◽  
Vol 19 (6) ◽  
pp. 522-533 ◽  
Author(s):  
Ann M. Farese ◽  
Daniel B. Casey ◽  
Walter G. Smith ◽  
Roy M. Vigneulle ◽  
John P. McKearn ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Receptor Agonist ◽  
Route Of Administration ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Hematopoietic Recovery ◽  
Radiation Induced ◽  
Schedule Dose

Effects of a Prostaglandin DP Receptor Agonist, AL-6598, on Aqueous Humor Dynamics in a Nonhuman Primate Model of Glaucoma

2006 ◽  
Vol 22 (2) ◽  
pp. 86-92 ◽  
Author(s):  
Carol B. Toris ◽  
Gui-Lin Zhan ◽  
Michael R. Feilmeier ◽  
Carl B. Camras ◽  
Marsha A. McLaughlin
Keyword(s):  
Aqueous Humor ◽  
Nonhuman Primate ◽  
Receptor Agonist ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Aqueous Humor Dynamics

scholarly journals A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury

2014 ◽  
Vol 88 (2) ◽  
pp. 404-411 ◽  
Author(s):  
Govardhana Rao Yannam ◽  
Bing Han ◽  
Kentaro Setoyama ◽  
Toshiyuki Yamamoto ◽  
Ryotaro Ito ◽  
...  
Keyword(s):  
Liver Disease ◽  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Hepatocyte Injury ◽  
Radiation Induced

scholarly journals Therapeutic efficacy of recombinant interleukin-6 (IL-6) alone and combined with recombinant human IL-3 in a nonhuman primate model of high-dose, sublethal radiation-induced marrow aplasia

Blood ◽  
1994 ◽  
Vol 84 (8) ◽  
pp. 2515-2522 ◽  
Author(s):  
TJ MacVittie ◽  
AM Farese ◽  
ML Patchen ◽  
LA Myers
Keyword(s):  
Bone Marrow ◽  
Nonhuman Primate ◽  
High Dose ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Treatment Protocols ◽  
Sequential Administration ◽  
Radiation Induced ◽  
Complete Blood Counts ◽  
Bone Marrow Regeneration

Abstract Using a nonhuman-primate model of radiation-induced bone marrow aplasia, we examined whether the single, concomitant, or sequential administration of recombinant human interleukin-3 (IL-3) and IL-6 would promote bone marrow regeneration measured by an increase in circulating platelets (PLT) and neutrophils (PMN). Rhesus monkeys were irradiated at 450 cGy and were randomly assigned to one of five treatment protocols, receiving IL-6; IL-3; combined IL-6 and IL-3; sequential IL- 3 and IL-6; or human serum albumin (HSA) as a control. Cytokines or HSA were administered at total dosages of 15 micrograms/kg/day. Complete blood counts and white blood cell differentials were monitored for 60 days postirradiation. Both IL-3 and IL-6 significantly enhanced the regeneration of PLTs and decreased the duration of thrombocytopenia (P = .005) without affecting PMN recovery. The radiation-induced anemia that was observed in the HSA-treated controls was less severe and resolved more quickly in the IL-6 treated animals. Sequential IL-3/IL-6 significantly increased the production of PLTs when compared with the HSA-treated controls (P = .003) and monkeys receiving concomitant IL- 3/IL-6 (P = .041) but did not alter PMN levels significantly (P = .80). Coadministration of IL-6 and IL-3 did not enhance PLT but improved PMN recovery over IL-6 alone. In this primate model of marrow aplasia, IL-6 significantly enhanced the regeneration of PLTs but had no significant effect on PMN production, and did not exacerbate radiation-induced anemia. Furthermore, the use of sequentially administered IL-3 and IL-6 may improve PLT recovery as compared with concurrent IL-3/IL-6 administration, although this protocol is not significantly different in effect than either cytokine alone.

scholarly journals Therapeutic efficacy of recombinant interleukin-6 (IL-6) alone and combined with recombinant human IL-3 in a nonhuman primate model of high-dose, sublethal radiation-induced marrow aplasia

Blood ◽  
1994 ◽  
Vol 84 (8) ◽  
pp. 2515-2522
Author(s):  
TJ MacVittie ◽  
AM Farese ◽  
ML Patchen ◽  
LA Myers
Keyword(s):  
Bone Marrow ◽  
Nonhuman Primate ◽  
High Dose ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Treatment Protocols ◽  
Sequential Administration ◽  
Radiation Induced ◽  
Complete Blood Counts ◽  
Bone Marrow Regeneration

Using a nonhuman-primate model of radiation-induced bone marrow aplasia, we examined whether the single, concomitant, or sequential administration of recombinant human interleukin-3 (IL-3) and IL-6 would promote bone marrow regeneration measured by an increase in circulating platelets (PLT) and neutrophils (PMN). Rhesus monkeys were irradiated at 450 cGy and were randomly assigned to one of five treatment protocols, receiving IL-6; IL-3; combined IL-6 and IL-3; sequential IL- 3 and IL-6; or human serum albumin (HSA) as a control. Cytokines or HSA were administered at total dosages of 15 micrograms/kg/day. Complete blood counts and white blood cell differentials were monitored for 60 days postirradiation. Both IL-3 and IL-6 significantly enhanced the regeneration of PLTs and decreased the duration of thrombocytopenia (P = .005) without affecting PMN recovery. The radiation-induced anemia that was observed in the HSA-treated controls was less severe and resolved more quickly in the IL-6 treated animals. Sequential IL-3/IL-6 significantly increased the production of PLTs when compared with the HSA-treated controls (P = .003) and monkeys receiving concomitant IL- 3/IL-6 (P = .041) but did not alter PMN levels significantly (P = .80). Coadministration of IL-6 and IL-3 did not enhance PLT but improved PMN recovery over IL-6 alone. In this primate model of marrow aplasia, IL-6 significantly enhanced the regeneration of PLTs but had no significant effect on PMN production, and did not exacerbate radiation-induced anemia. Furthermore, the use of sequentially administered IL-3 and IL-6 may improve PLT recovery as compared with concurrent IL-3/IL-6 administration, although this protocol is not significantly different in effect than either cytokine alone.

Maternal High-Fat Diet Persistently Alters Bone Marrow Immune Cell Proportions and Function in a Nonhuman Primate Model

Diabetes ◽  
2018 ◽  
Vol 67 (Supplement 1) ◽  
pp. 222-OR
Author(s):  
MICHAEL J. NASH ◽  
TAYLOR K. SODERBORG ◽  
RACHEL C. JANSSEN ◽  
ERIC M. PIETRAS ◽  
JACOB E. FRIEDMAN
Keyword(s):  
Bone Marrow ◽  
Nonhuman Primate ◽  
High Fat Diet ◽  
Immune Cell ◽  
High Fat ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
And Function

scholarly journals Reperfusion plus Selective Intra-arterial Cooling (SI-AC) Improve Recovery in a Nonhuman Primate Model of Stroke

2020 ◽  
Author(s):  
Di Wu ◽  
Yongjuan Fu ◽  
Longfei Wu ◽  
Mitchell Huber ◽  
Jian Chen ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model
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