Administration of Recombinant Human Thrombopoietin Soon after Irradiation Promotes Survival and Stimulates Hematopoietic Recovery in a Nonhuman Primate Model of Radiation-Induced Severe Acute Radiation Syndrome

2011 ◽  
Vol 41 (10) ◽  
pp. 938-944
Author(s):  
Ming LI ◽  
RuiYun PENG ◽  
LingLing GUO ◽  
Lei WANG ◽  
GuoLin XIONG ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Acute Radiation ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Acute Radiation Syndrome ◽  
Hematopoietic Recovery ◽  
Radiation Induced ◽  
Recombinant Human Thrombopoietin

scholarly journals A Nonhuman Primate Model of the Hematopoietic Acute Radiation Syndrome Plus Medical Management

2012 ◽  
Vol 103 (4) ◽  
pp. 367-382 ◽  
Author(s):  
Ann M. Farese ◽  
Melanie V. Cohen ◽  
Barry P. Katz ◽  
Cassandra P. Smith ◽  
William Jackson ◽  
...  
Keyword(s):  
Nonhuman Primate ◽  
Medical Management ◽  
Acute Radiation ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Acute Radiation Syndrome

scholarly journals A Nonhuman Primate Model of Human Radiation-Induced Venocclusive Liver Disease and Hepatocyte Injury

2014 ◽  
Vol 88 (2) ◽  
pp. 404-411 ◽  
Author(s):  
Govardhana Rao Yannam ◽  
Bing Han ◽  
Kentaro Setoyama ◽  
Toshiyuki Yamamoto ◽  
Ryotaro Ito ◽  
...  
Keyword(s):  
Liver Disease ◽  
Nonhuman Primate ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Hepatocyte Injury ◽  
Radiation Induced

scholarly journals Therapeutic efficacy of recombinant interleukin-6 (IL-6) alone and combined with recombinant human IL-3 in a nonhuman primate model of high-dose, sublethal radiation-induced marrow aplasia

Blood ◽  
1994 ◽  
Vol 84 (8) ◽  
pp. 2515-2522 ◽  
Author(s):  
TJ MacVittie ◽  
AM Farese ◽  
ML Patchen ◽  
LA Myers
Keyword(s):  
Bone Marrow ◽  
Nonhuman Primate ◽  
High Dose ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Treatment Protocols ◽  
Sequential Administration ◽  
Radiation Induced ◽  
Complete Blood Counts ◽  
Bone Marrow Regeneration

Abstract Using a nonhuman-primate model of radiation-induced bone marrow aplasia, we examined whether the single, concomitant, or sequential administration of recombinant human interleukin-3 (IL-3) and IL-6 would promote bone marrow regeneration measured by an increase in circulating platelets (PLT) and neutrophils (PMN). Rhesus monkeys were irradiated at 450 cGy and were randomly assigned to one of five treatment protocols, receiving IL-6; IL-3; combined IL-6 and IL-3; sequential IL- 3 and IL-6; or human serum albumin (HSA) as a control. Cytokines or HSA were administered at total dosages of 15 micrograms/kg/day. Complete blood counts and white blood cell differentials were monitored for 60 days postirradiation. Both IL-3 and IL-6 significantly enhanced the regeneration of PLTs and decreased the duration of thrombocytopenia (P = .005) without affecting PMN recovery. The radiation-induced anemia that was observed in the HSA-treated controls was less severe and resolved more quickly in the IL-6 treated animals. Sequential IL-3/IL-6 significantly increased the production of PLTs when compared with the HSA-treated controls (P = .003) and monkeys receiving concomitant IL- 3/IL-6 (P = .041) but did not alter PMN levels significantly (P = .80). Coadministration of IL-6 and IL-3 did not enhance PLT but improved PMN recovery over IL-6 alone. In this primate model of marrow aplasia, IL-6 significantly enhanced the regeneration of PLTs but had no significant effect on PMN production, and did not exacerbate radiation-induced anemia. Furthermore, the use of sequentially administered IL-3 and IL-6 may improve PLT recovery as compared with concurrent IL-3/IL-6 administration, although this protocol is not significantly different in effect than either cytokine alone.

scholarly journals Therapeutic efficacy of recombinant interleukin-6 (IL-6) alone and combined with recombinant human IL-3 in a nonhuman primate model of high-dose, sublethal radiation-induced marrow aplasia

Blood ◽  
1994 ◽  
Vol 84 (8) ◽  
pp. 2515-2522
Author(s):  
TJ MacVittie ◽  
AM Farese ◽  
ML Patchen ◽  
LA Myers
Keyword(s):  
Bone Marrow ◽  
Nonhuman Primate ◽  
High Dose ◽  
Nonhuman Primate Model ◽  
Primate Model ◽  
Treatment Protocols ◽  
Sequential Administration ◽  
Radiation Induced ◽  
Complete Blood Counts ◽  
Bone Marrow Regeneration

Using a nonhuman-primate model of radiation-induced bone marrow aplasia, we examined whether the single, concomitant, or sequential administration of recombinant human interleukin-3 (IL-3) and IL-6 would promote bone marrow regeneration measured by an increase in circulating platelets (PLT) and neutrophils (PMN). Rhesus monkeys were irradiated at 450 cGy and were randomly assigned to one of five treatment protocols, receiving IL-6; IL-3; combined IL-6 and IL-3; sequential IL- 3 and IL-6; or human serum albumin (HSA) as a control. Cytokines or HSA were administered at total dosages of 15 micrograms/kg/day. Complete blood counts and white blood cell differentials were monitored for 60 days postirradiation. Both IL-3 and IL-6 significantly enhanced the regeneration of PLTs and decreased the duration of thrombocytopenia (P = .005) without affecting PMN recovery. The radiation-induced anemia that was observed in the HSA-treated controls was less severe and resolved more quickly in the IL-6 treated animals. Sequential IL-3/IL-6 significantly increased the production of PLTs when compared with the HSA-treated controls (P = .003) and monkeys receiving concomitant IL- 3/IL-6 (P = .041) but did not alter PMN levels significantly (P = .80). Coadministration of IL-6 and IL-3 did not enhance PLT but improved PMN recovery over IL-6 alone. In this primate model of marrow aplasia, IL-6 significantly enhanced the regeneration of PLTs but had no significant effect on PMN production, and did not exacerbate radiation-induced anemia. Furthermore, the use of sequentially administered IL-3 and IL-6 may improve PLT recovery as compared with concurrent IL-3/IL-6 administration, although this protocol is not significantly different in effect than either cytokine alone.

Sign in / Sign up

Export Citation Format

Share Document