scholarly journals Modeling the neuro-protection of theaflavic acid from black tea and its synergy with nimodipine via mitochondria apoptotic pathway

2021 ◽  
Vol 22 (2) ◽  
pp. 123-135
Author(s):  
Dan Mu ◽  
Huaguang Qin ◽  
Mengjie Jiao ◽  
Shaogui Hua ◽  
Tingzhe Sun
Keyword(s):  
Black Tea ◽  
Apoptotic Pathway ◽  
Neuro Protection

Apoptosis and development

2003 ◽  
Vol 39 ◽  
pp. 11-24 ◽  
Author(s):  
Justin V McCarthy
Keyword(s):  
Drosophila Melanogaster ◽  
Mammalian Cells ◽  
Cell Number ◽  
Model Organisms ◽  
Biological Processes ◽  
Nematode Caenorhabditis Elegans ◽  
Apoptotic Pathway ◽  
Genetic Pathways ◽  
Evolutionarily Conserved ◽  
Multicellular Organisms

Apoptosis is an evolutionarily conserved process used by multicellular organisms to developmentally regulate cell number or to eliminate cells that are potentially detrimental to the organism. The large diversity of regulators of apoptosis in mammalian cells and their numerous interactions complicate the analysis of their individual functions, particularly in development. The remarkable conservation of apoptotic mechanisms across species has allowed the genetic pathways of apoptosis determined in lower species, such as the nematode Caenorhabditis elegans and the fruitfly Drosophila melanogaster, to act as models for understanding the biology of apoptosis in mammalian cells. Though many components of the apoptotic pathway are conserved between species, the use of additional model organisms has revealed several important differences and supports the use of model organisms in deciphering complex biological processes such as apoptosis.

The apoptotic pathway is disturbed in the active and inactive celiac disease

2001 ◽  
Vol 120 (5) ◽  
pp. A131-A131
Author(s):  
J VANDERWOUDE ◽  
T TIEBOSCH ◽  
M HOMAN ◽  
A BEUVING ◽  
J KLEIBEUKER ◽  
...  
Keyword(s):  
Celiac Disease ◽  
Apoptotic Pathway

Microarray reveals positive effects of green and black tea polyphenols on TNF[alpha]-induced changes of gene expression

2013 ◽  
Author(s):  
Husna Zulkipli ◽  
Norita Salim ◽  
Gabriele Anisah Froemming ◽  
Aletza Mohd Ismail ◽  
Hapizah Nawawi
Keyword(s):  
Gene Expression ◽  
Black Tea ◽  
Tea Polyphenols ◽  
Tnf Alpha ◽  
Positive Effects ◽  
Black Tea Polyphenols ◽  
Green And Black Tea ◽  
Induced Changes

Black Tea-Induced Amelioration of Hepatic Oxidative Stress through Antioxidative Activity in EAC-Bearing Mice

2007 ◽  
Vol 26 (4) ◽  
pp. 245-254 ◽  
Author(s):  
Arindam Bhattacharyya ◽  
Debaprasad Mandal ◽  
Lakshmishri Lahiry ◽  
Sankar Bhattacharyya ◽  
Sreya Chattopadhyay ◽  
...  
Keyword(s):  
Oxidative Stress ◽  
Antioxidative Activity ◽  
Black Tea ◽  
Hepatic Oxidative Stress ◽  
Induced Amelioration

The warburg effect and tumour cell survival in human GBMs

2007 ◽  
Vol 30 (4) ◽  
pp. 97 ◽  
Author(s):  
A Wolf ◽  
J Mukherjee ◽  
A Guha
Keyword(s):  
Cytochrome C ◽  
Cell Survival ◽  
Expression Profile ◽  
Tumour Cell ◽  
Warburg Effect ◽  
Glycolytic Enzymes ◽  
Cytochrome C Release ◽  
Apoptotic Pathway ◽  
The Warburg Effect

Introduction: GBMs are resistant to apoptosis induced by the hypoxic microenvironment and standard therapies including radiation and chemotherapy. We postulate that the Warburg effect, a preferential glycolytic phenotype of tumor cells even under aerobic conditions, plays a role in these aberrant pro-survival signals. In this study we quantitatively examined the expression profile of hypoxia-related glycolytic genes within pathologically- and MRI-defined “centre” and “periphery” of GBMs. We hypothesize that expression of hypoxia-induced glycolytic genes, particularly hexokinase 2 (HK2), favours cell survival and modulates resistance to tumour cell apoptosis by inhibiting the intrinsic mitochondrial apoptotic pathway. Methods: GBM patients underwent conventional T1-weighted contrast-enhanced MRI and MR spectroscopy studies on a 3.0T GE scanner, prior to stereotactic sampling (formalin and frozen) from regions which were T1-Gad enhancing (“centre”) and T2-positive, T1-Gad negative (“periphery”). Real-time qRT-PCR was performed to quantify regional gene expression of glycolytic genes including HK2. In vitro functional studies were performed in U87 and U373 GBM cell lines grown in normoxic (21% pO2) and hypoxic (< 1%pO2) conditions, transfected with HK2 siRNA followed by measurement of cell proliferation (BrdU), apoptosis (activated caspase 3/7, TUNEL, cytochrome c release) and viability (MTS assay). Results: There exists a differential expression profile of glycolytic enzymes between the hypoxic center and relatively normoxic periphery of GBMs. Under hypoxic conditions, there is increased expression of HK2 at the mitochondrial membrane in GBM cells. In vitro HK2 knockdown led to decreased cell survival and increased apoptosis via the intrinsic mitochondrial pathway, as seen by increased mitochondrial release of cytochrome-C. Conclusions: Increased expression of HK2 in the centre of GBMs promotes cell survival and confers resistance to apoptosis, as confirmed by in vitro studies. In vivo intracranial xenograft studies with injection of HK2-shRNA are currently being performed. HK2 and possibly other glycolytic enzymes may provide a target for enhanced therapeutic responsiveness thereby improving prognosis of patients with GBMs.

ANALISIS KINERJA PABRIK TEH HITAM “PAHIT MADU”

2013 ◽  
Vol 13 (3) ◽  
Author(s):  
Djawardi Djawardi ◽  
Yustiar Gunawan
Keyword(s):  
Heat Exchanger ◽  
Production Process ◽  
Black Tea ◽  
Production Equipment ◽  
Standard Means ◽  
Fluid Bed ◽  
Calculation Results ◽  
Low Performance ◽  
Equipment Utilization

The business unit's black tea processing of Perkebunan Nusantara suffered a loss of approximately Rp.60 billion. This is caused by the failure to achieve the quality and quantity of production which has been targeted by the management. Black tea processing factory "Pahit Madu" is required to improve the performance of the production process. To improve the production of black tea starts from improved production equipment through improved equipment utilization. One method ofmeasuring the effectiveness of using an apparatus is Overall EquipmentEffectiveness (OEE). OEE calculation results show that black tea factory "Pahit Madu" for four (4) years under the standard. Means, the effectiveness of utilization of equipment in the factory black tea "Pahit Madu" was still very low. This was shown by the low performance equipment in the milling unit, drying unit and sortation unit. Toimprove the performance of the plant should begin by increasing the Cutting Tearing Curling (CTC) machine in milling stations, machines Fluid Bed Dryer (FBD) and Heat Exchanger (HE) at the drying stations, and Winnower machines at the sortation stations.

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