scholarly journals The Relation between Experimental Liver Carcinoma and Liver Cirrhosis Induced by Successive Administration of p-Dimethylaminoazo-benzene and Carbon Tetrachloride

1967 ◽  
Vol 92 (2) ◽  
pp. 109-140 ◽  
Author(s):  
Yoshikyo Ueda
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Liver Carcinoma ◽  
Experimental Liver

scholarly journals Review of experimental models for inducing hepatic cirrhosis by bile duct ligation and carbon tetrachloride injection

2012 ◽  
Vol 27 (8) ◽  
pp. 589-594 ◽  
Author(s):  
Thamirys Guimarães Marques ◽  
Eleazar Chaib ◽  
Juliana Hamati da Fonseca ◽  
Ana Cecília Rodrigues Lourenço ◽  
Felipe Duarte Silva ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Bile Duct ◽  
Web Sites ◽  
Bile Duct Ligation ◽  
Experimental Models ◽  
Duct Ligation ◽  
Experimental Liver Cirrhosis ◽  
Experimental Liver ◽  
Better Than

PURPOSE: To present a review about a comparative study of bile duct ligation versus carbon tetrachloride Injection for inducing experimental liver cirrhosis. METHODS: This research was made through Medline/PubMed and SciELO web sites looking for papers on the content "induction of liver cirrhosis in rats". We have found 107 articles but only 30 were selected from 2004 to 2011. RESULTS: The most common methods used for inducing liver cirrhosis in the rat were administration of carbon tetrachloride (CCl4) and bile duct ligation (BDL). CCl4 has induced cirrhosis from 36 hours to 18 weeks after injection and BDL from seven days to four weeks after surgery. CONCLUSION: For a safer inducing cirrhosis method BDL is better than CCl4 because of the absence of toxicity for researches and shorter time for achieving it.

scholarly journals Antifibrogenic effect of melatonin in rats with experimental liver cirrhosis induced by carbon tetrachloride

JGH Open ◽  
2018 ◽  
Vol 2 (4) ◽  
pp. 117-123 ◽  
Author(s):  
Silvia Bona ◽  
Graziella Rodrigues ◽  
Andrea J Moreira ◽  
Fábio C Di Naso ◽  
Alexandre S Dias ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Experimental Liver Cirrhosis ◽  
Antifibrogenic Effect ◽  
Experimental Liver

scholarly journals Evaluation of the spontaneous reversibility of carbon tetrachloride-induced liver cirrhosis in rabbits

2012 ◽  
Vol 46 (2) ◽  
pp. 122-128 ◽  
Author(s):  
E Bravo ◽  
E D'Amore ◽  
F Ciaffoni ◽  
C L Mammola
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Treatment Interruption ◽  
Experimental Models ◽  
Morphometric Study ◽  
Postnecrotic Cirrhosis ◽  
Semiquantitative Evaluation ◽  
Hepatocyte Necrosis ◽  
And Control ◽  
Experimental Liver

There is a general consensus that liver fibrosis in humans is potentially reversible, while scepticism prevails on the concept that cirrhosis can be truly reversed. The availability of suitable experimental models is fundamental for disease research. The experimental murine model of liver cirrhosis induced by carbon tetrachloride (CCl4) reproduces both the histological picture of the postnecrotic cirrhosis and its biochemical and clinical parameters. Normal hepatic structure is modified by formation of regeneration nodules. Fibrosis represents a morphological element of disease and an effect of hepatocyte necrosis. However, the relevance for research of this well-established model of liver cirrhosis is hampered by some spontaneous cirrhosis regression reported in mice and rats. It has been reported that CCl4 also induces experimental liver cirrhosis in rabbits, but it is not known whether the process is reversible in this species. The aim of our study was to investigate this question. Male New Zealand White rabbits were treated intragastrically with CCl4 or the vehicle only for 19 weeks and groups were sacrificed three and five months after treatment interruption. Cirrhotic and control livers were processed for routine light microscopy and for morphometric study of fibrosis by semiquantitative evaluation. The degree of fibrosis was based on the Knodell's scoring system.

The efficacy of fp 736-04 in experimental liver cirrhosis

1998 ◽  
Vol 39 (5) ◽  
pp. 568-571
Author(s):  
A. Bergman ◽  
A. Magnusson ◽  
K. Moore ◽  
A. Sundin ◽  
S. Davies ◽  
...  
Keyword(s):  
Liver Cirrhosis ◽  
Experimental Liver Cirrhosis ◽  
Experimental Liver

EFFECTS OF NATURAL AND RECOMBINANT INTERFERON ON CARBON TETRACHLORIDE- INDUCED LIVER CIRRHOSIS

2001 ◽  
Vol 10 (2) ◽  
pp. 11-17
Author(s):  
Mohamed Hassan ◽  
Mona El-Azab ◽  
EI-Sayed El-Awady ◽  
Soad Abou-El-Ela
Keyword(s):  
Liver Cirrhosis ◽  
Carbon Tetrachloride ◽  
Recombinant Interferon
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