scholarly journals Prevalence of Escherichia coli Resistant to Beta-Lactam Antibiotics among Patients with Chronic Obstructive Pulmonary Disease and Urinary Tract Infection

2018 ◽  
Vol 244 (4) ◽  
pp. 271-277 ◽  
Author(s):  
Emilija Nikolić ◽  
Tijana Brandmajer ◽  
Vesna Bokan ◽  
Maria Ulyashova ◽  
Maya Rubtsova
Keyword(s):  
Escherichia Coli ◽  
Chronic Obstructive Pulmonary Disease ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Pulmonary Disease ◽  
Chronic Obstructive ◽  
Beta Lactam ◽  
Obstructive Pulmonary Disease ◽  
Beta Lactam Antibiotics

scholarly journals Prevalence of Plasmid-Mediated Quinolone Resistance Determinants and OqxAB Efflux Pumps among Extended-Spectrumβ-Lactamase ProducingKlebsiella pneumoniaeIsolated from Patients with Nosocomial Urinary Tract Infection in Tehran, Iran

Scientifica ◽  
2015 ◽  
Vol 2015 ◽  
pp. 1-7 ◽  
Author(s):  
Mehdi Goudarzi ◽  
Mehdi Azad ◽  
Sima Sadat Seyedjavadi
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Antimicrobial Agents ◽  
Quinolone Resistance ◽  
Beta Lactam ◽  
Beta Lactam Antibiotics ◽  
Nosocomial Urinary Tract Infection ◽  
Clinical Resistance ◽  
Synergy Test

Objective. Plasmid-mediated quinolone resistance (PMQR) plays an important role in the development of clinical resistance to quinolone. The aim of this study was to investigate PMQR determinants among extended-spectrumβ-lactamases- (ESBL-) producingKlebsiella pneumoniaerecovered from patients with nosocomial urinary tract infection (UTI).Methods. A total of 247 ESBL-producingK. pneumoniaeisolates were collected from 750 patients with UTI. ESBL production was confirmed by double disc synergy test and combined disc diffusion test. The prevalence of PMQR determinants among ESBL-producingK. pneumoniaewas assessed using PCR method.Results. The rates of resistance to antimicrobial agents in present study varied from 14.2% to 98.8%. In comparison with other PMQR genotypes, the frequency ofaac(6′)-Ib(68.8%) was strikingly high. Of the 247 isolates tested,qnrA, qnrB, qnrS,andqepAgenes were present in 3.6%, 1.6%, 1.2, and 2%, respectively.oqxAandoqxBwere detected in 56.7% and 54.6% of isolates. The predominant coexisting ESBL and PMQR profile among our isolates includedblaCTX-Mandaac(6′)-Ib, oqxA, oqxB(28.3%) andblaTEM,blaSHVandaac(6′)-Ib, oqxA,andoqxB(19.4%) profile.  Conclusion. Given the linkage observed between resistance to quinolones and beta lactam antibiotics, therapeutic protocol with fluoroquinolones and beta lactam antibiotics should be seriously revised in Tehran hospitals.

scholarly journals Assessment of SHV, CTX-M, and IMP Genes in Beta-Lactam-Resistant Escherichia coli Isolated from Patients with Urinary Tract Infection

2019 ◽  
Vol 6 (3) ◽  
Author(s):  
Anna Abdolshahi ◽  
Zahra Aminian ◽  
Tahereh Zinati ◽  
Aliakbar Shabani ◽  
Mehrdad Khaledi ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Beta Lactam

scholarly journals Urinary tract infection is associated with hypokalemia: a case control study

2020 ◽  
Author(s):  
Ai-Ling Shen ◽  
Hsiu-Li Lin ◽  
Hsiu-Chen Lin ◽  
Yuan-Fu Tseng ◽  
Chien-Yeh Hsu ◽  
...  
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Beta Blockers ◽  
Clinical Problem ◽  
Control Group ◽  
Chronic Obstructive ◽  
Chi Square ◽  
Obstructive Pulmonary Disease ◽  
Control Study

Abstract BackgroundHypokalemia is a common clinical problem. The association between urinary tract infection (UTI) and hypokalemia is not clear. Hypokalemia is common in patients with UTI in clinical observation. The aim of the study is to determine if UTI is associated with hypokalemia.Methods Patients hospitalized with UTI and the control group were retrieved from the Longitudinal Health Insurance Database 2005. The control group was patients hospitalized with other reasons and were matched for the confoundings of UTI and hypokalemia. We analyze the risk of hypokalemia using logistic regression and calculate the odds ratio (OR) and 95% confidence interval (CI) of OR.ResultsWe analyzed 44952 UTI patients and 44952 matched control patients. The percentage (10.3%, n=4625) of hypokalemia was higher in UTI patients than that (5.2%, n=2342) in control patients (chi-square, p < 0.001). UTI was associated with hypokalemia (p < 0.001) and the OR was 2.04 (95% CI 1.94 - 2.16). Cerebrovascular accident, chronic obstructive pulmonary disease, diabetes, hypertension, congestive heart failure, and medications including diuretics, beta-blockers, insulin, and laxatives were also associated with hypokalemia. Recurrent UTI was associated with hypokalemia in patients with UTI.ConclusionsHypokalemia is linked to urinary tract infection and potassium should be tested in UTI patients. The association of hypokalemia and UTI is independent of patients’ comorbidities and medications.

scholarly journals Statin prescription in patients with chronic obstructive pulmonary disease and risk of exacerbations: a retrospective cohort study in the Clinical Practice Research Datalink

BMJ Open ◽  
2021 ◽  
Vol 11 (12) ◽  
pp. e050757
Author(s):  
Margaret C Smith ◽  
Helen Frances Ashdown ◽  
James Peter Sheppard ◽  
Christopher C Butler ◽  
Clare Bankhead
Keyword(s):  
Urinary Tract Infection ◽  
Urinary Tract ◽  
Tract Infection ◽  
Practice Research ◽  
Chronic Obstructive ◽  
Clinical Practice Research Datalink ◽  
Severe Exacerbation ◽  
Copd Exacerbation ◽  
Obstructive Pulmonary Disease

ObjectiveObservational studies have suggested a beneficial effect of taking statins on frequency of chronic obstructive pulmonary disease (COPD) exacerbations. However, clinical trials of statins in people with COPD did not confirm those results. This study aimed to investigate this association using a methodological approach, which reduces the biases associated with some previous observational study designs.DesignRetrospective cohort study comparing new-users of statins with non-users.SettingGeneral practices in England contributing to the Clinical Practice Research Datalink in 2007–2017, with linkage to data on Hospital Episode Statistics inpatient episodes.Participants48 124 people with COPD, aged over 40 years, who had not been prescribed statin in the previous year.ExposureParticipants became new-users of statins at their first prescription for a statin during follow-up. They were then assumed to remain statin users. Statin users were compared with non-users.OutcomesPrimary outcomes were COPD exacerbation, or severe exacerbation requiring hospitalisation. Secondary outcomes were death from any cause (for comparison with other studies) and urinary tract infection (negative-control). Maximum follow-up was 3 years. Adjusted HR were calculated using time-dependent Cox regression. The Andersen-Gill model was used for recurrent exacerbations. Covariates included demographic variables, variables related to COPD severity, cardiovascular comorbidities as time-dependent variables, and other comorbidities at baseline.Results7266 participants became new-users of statins over an average 2.5 years of follow-up. In total, 30 961 people developed an exacerbation, 8110 severe exacerbation, 3650 urinary tract infection and 5355 died. Adjusted HR (95% CI) in statin users compared with non-users were first exacerbation 1.01 (0.96–1.06), severe exacerbation 0.92 (0.84–0.99), number of exacerbations 1.00 (0.97–1.04), urinary tract infection 1.10 (0.98–1.23) and death 0.63 (0.57–0.70).ConclusionsIn this study of health records from a Primary Care database, statin use in people with COPD was not associated with a lower risk of COPD exacerbation.

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