scholarly journals Serum Interleukin-2 and Neopterin Levels as Useful Markers for Treatment of Active Pulmonary Tuberculosis

2006 ◽  
Vol 209 (4) ◽  
pp. 321-328 ◽  
Author(s):  
Teyfik Turgut ◽  
Handan Akbulut ◽  
Figen Deveci ◽  
Canan Kacar ◽  
M. Hamdi Muz
Keyword(s):  
Pulmonary Tuberculosis ◽  
Interleukin 2 ◽  
Active Pulmonary Tuberculosis

scholarly journals Combined IFN-γ and IL-2 release assay for detect active pulmonary tuberculosis: a prospective multicentre diagnostic study in China

2021 ◽  
Vol 19 (1) ◽  
Author(s):  
Yaoju Tan ◽  
Yunhong Tan ◽  
Junlian Li ◽  
Pengnan Hu ◽  
Ping Guan ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Interleukin 2 ◽  
Enzyme Linked Immunosorbent Assay ◽  
Diagnostic Study ◽  
Pulmonary Tb ◽  
Active Pulmonary Tuberculosis ◽  
Presenting Symptoms ◽  
Release Assay ◽  
Ifn Γ ◽  
Combination Test

Abstract Background We performed a prospective multicentre diagnostic study to evaluate the combined interferon-γ (IFN-γ) and interleukin-2 (IL-2) release assay for detect active pulmonary tuberculosis (TB) in China. Methods Adult patients presenting symptoms suggestive of pulmonary TB were consecutively enrolled in three TB-specialized hospitals. Sputum specimens and blood sample and were collected from each participant at enrolment. The levels of Mycobacterium tuberculosis (MTB)-specific antigen-stimulated IFN-γ and IL-2 were determined using enzyme-linked immunosorbent assay (ELISA). Results Between July 2017 and December 2018, a total of 3245 patients with symptoms suggestive of pulmonary TB were included in final analysis. Of 3245 patients, 2536 were diagnosed as active TB, consisting of 1092 definite TB and 1444 clinically diagnosed TB. The overall sensitivity and specificity of IFN-γ were 83.8% and 81.5%, respectively. In addition, compared with IFN-γ, the specificity of IL-2 increased to 94.3%, while the sensitivity decreased to 72.6%. In addition, the highest sensitivity was achieved with parallel combination of IFN-γ/IL-2, with a sensitivity of 87.9%, and its overall specificity was 79.8%. The sensitivity of series combination test was 68.5%. Notably, the sensitivity of series combination test in definite TB (72.1%) was significantly higher than that in clinically diagnosed TB (65.8%). Conclusion In conclusion, we develop a new immunological method that can differentiate between active TB and other pulmonary diseases. Our data demonstrates that the various IFN-γ/IL-2 combinations provides promising alternatives for diagnosing active TB cases in different settings. Additionally, the diagnostic accuracy of series combination correlates with severity of disease in our cohort.

scholarly journals Correlation of serum tumor necrosis factor-α, interleukin-4 and soluble interleukin-2 receptor levels with radiologic and clinical manifestations in active pulmonary tuberculosis

2003 ◽  
Vol 12 (1) ◽  
pp. 9-14 ◽  
Author(s):  
Levent Kart ◽  
Hakan Buyukoglan ◽  
Ishak O. Tekin ◽  
Remzi Altin ◽  
Zuhal Senturk ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Tumor Necrosis ◽  
Interleukin 2 ◽  
Clinical Manifestations ◽  
Interleukin 4 ◽  
Active Pulmonary Tuberculosis ◽  
Tnf Α ◽  
Soluble Interleukin 2 Receptor ◽  
Factor Α ◽  
Necrosis Factor

The precise clinical manifestations of tuberculosis are likely to result from a complex interaction between the host and the pathogen. We took serum samples from a group of patients with a variety of clinical and radiological stages of pulmonary tuberculosis in order to characterize tumor necrosis factor-α (TNF-α), interleukin-4 (IL-4) and soluble interleukin-2 receptor (sIL-2R) response. We further evaluated whether the levels of TNF-α, IL-4 and soluble IL-2R are related with each other, and also evaluated the levels of TNF-α, IL-4 and sIL-2R after anti-tuberculosis therapy and relation with radiologic scores. Forty-three inpatients with active pulmonary tuberculosis and 19 healthy controls participated in the study. Patients were divided into four categories radiologically on chest X-ray (minimal, moderate-advanced, far-advanced and with miliary infiltration). Concentrations of TNF-α (20.9±10/15.4±8 pg/ml) and sIL-2R (2569±842/1444±514 pg/ml) were statistically different between patients and controls (p=0.02andp=0.0001, respectively). Before chemotherapy there was a positive correlation between TNF-α and sIL-2R(r=0.34), but there was no correlation between IL-4 and TNF-α, and between IL-4 and sIL-2R(r=−0.23andr=−0.22). The TNF-α level was not statistically different in four groups before and after chemotherapy. Results of this study provided some evidence confirming the previously reported role of TNF-α, IL-4 and sIL 2R in the control of tuberculosis, but these cytokines were not found related with disease severity.

scholarly journals Metabolism of Heterogenic Hemoglobins

Blood ◽  
1963 ◽  
Vol 22 (3) ◽  
pp. 334-341 ◽  
Author(s):  
RICHARD D. LEVERE ◽  
HERBERT C. LICHTMAN ◽  
Joan Levine
Keyword(s):  
Pulmonary Tuberculosis ◽  
Sickle Cell ◽  
Sickle Cell Trait ◽  
Hemoglobin S ◽  
Active Pulmonary Tuberculosis ◽  
Hemoglobin A ◽  
Abnormal Hemoglobin

Abstract The relative rates of incorporation of Fe59 into heterogenic hemoglobins was studied in four patients with sickle cell trait. Three of the patients were free of superimposed disease, while one had active pulmonary tuberculosis. In all subjects there was a significantly greater incorporation of radioiron, per milligram of hemoglobin, into hemoglobin S than into hemoglobin A. The data indicate that in sickle cell trait the rates of synthesis of the heterogenic hemoglobins are not proportional to their circulating concentrations. Two interpretations appear possible. Since the size of the intra-marrow pool of hemoglobin S was not known, it is possible that there exists a smaller preformed pool of the abnormal hemoglobin, with the isotope making its appearance first in hemoglobin S. However, it is also possible that hemoglobin S is synthesized at a rate which is greater than that reflected by its circulating concentration. This implies that the relative concentrations of hemoglobin S and hemoglobin A vary from erythrocyte to erythrocyte, and that those cells with the greatest proportion of hemoglobin S are selectively destroyed.

scholarly journals Screening tests for active pulmonary tuberculosis in children

2021 ◽  
Vol 2021 (6) ◽  
Author(s):  
Bryan Vonasek ◽  
Tara Ness ◽  
Yemisi Takwoingi ◽  
Alexander W Kay ◽  
Susanna S van Wyk ◽  
...  
Keyword(s):  
Pulmonary Tuberculosis ◽  
Screening Tests ◽  
Active Pulmonary Tuberculosis ◽  
Tuberculosis In Children
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