scholarly journals The effect of ursodeoxycholic acid on biliary bile acid composition in patients with cholesterol gallstone.

1982 ◽  
Vol 136 (3) ◽  
pp. 235-249 ◽  
Author(s):  
YOSHIHIKO KANAZAWA ◽  
MASARU KOIZUMI ◽  
HIDETOSHI HIRAKAWA ◽  
KATSUHIRO ENDO ◽  
SHIN YOSHIDA ◽  
...  
Keyword(s):  
Bile Acid ◽  
Ursodeoxycholic Acid ◽  
Acid Composition ◽  
Cholesterol Gallstone ◽  
Biliary Bile Acid

scholarly journals Metabolism of sulfonate analogs of ursodeoxycholic acid and their effects on biliary bile acid composition in hamsters.

1993 ◽  
Vol 34 (3) ◽  
pp. 429-435
Author(s):  
T Mikami ◽  
K Kihira ◽  
S Ikawa ◽  
M Yoshii ◽  
S Miki ◽  
...  
Keyword(s):  
Bile Acid ◽  
Ursodeoxycholic Acid ◽  
Acid Composition ◽  
Biliary Bile Acid

scholarly journals Effect of long term simvastatin administration as an adjunct to ursodeoxycholic acid: evidence for a synergistic effect on biliary bile acid composition but not on serum lipids in humans

Gut ◽  
1999 ◽  
Vol 44 (4) ◽  
pp. 552-556 ◽  
Author(s):  
F Lanzarotto ◽  
B Panarotto ◽  
R Sorbara ◽  
M Panteghini ◽  
F Pagani ◽  
...  
Keyword(s):  
Bile Acid ◽  
Synergistic Effect ◽  
Ursodeoxycholic Acid ◽  
Acid Composition ◽  
Ldl Cholesterol ◽  
Acid Synthesis ◽  
Bile Acid Synthesis ◽  
Cholesterol Concentration ◽  
Biliary Cholesterol ◽  
Biliary Bile Acid

BACKGROUNDStimulated bile acid synthesis preferentially utilises newly synthesised cholesterol, raising the posssiblity that combination of simvastatin (an inhibitor of cholesterol synthesis) with ursodeoxycholic acid (UDCA; a stimulator of bile acid synthesis) may result in reduced bile acid synthesis and greater enrichment of the pool with UDCA than that achieved with UDCA treatment alone.AIMSTo investigate the effect of simvastatin and UDCA given alone and in combination on serum and biliary lipid and biliary bile acid composition.METHODSEighteen patients with primary non-familial hypercholesterolaemia were studied during treatment with simvastatin 20 mg/day, UDCA 10 mg/kg/day, and a combination of the two drugs. Each regimen was given in random order for three months following a three month lead in period.RESULTSSimvastatin significantly reduced serum low density lipoprotein (LDL) cholesterol but biliary cholesterol concentration remained unchanged. Combination of the two drugs had no synergistic effect on serum cholesterol concentration, but significantly increased the proportion of UDCA in the bile acid pool from 35% during UDCA to 48% during combination treatment (p<0.04).CONCLUSIONSResults showed that: (1) simvastatin reduces serum LDL cholesterol but has no effect on biliary cholesterol concentration, supporting the concept that newly synthesised cholesterol is not the preferential source for biliary cholesterol; and (2) combination of simvastatin with UDCA has the predicted effect of enhancing the proportion of UDCA in the pool. This effect may be of benefit in the treatment of cholestatic liver diseases.

scholarly journals Biliary Bile Acid Composition of the Human Fetus in Early Gestation

1987 ◽  
Vol 21 (2) ◽  
pp. 197-200 ◽  
Author(s):  
C Colombo ◽  
G Zuliani ◽  
M Ronchi ◽  
J Breidenstein ◽  
K D R Setchel
Keyword(s):  
Bile Acid ◽  
Acid Composition ◽  
Human Fetus ◽  
Early Gestation ◽  
Biliary Bile Acid

BILIARY BILE ACID COMPOSITION OF THE PHYSETERIDAE (SPERM WHALES)

1993 ◽  
Vol 9 (1) ◽  
pp. 23-33 ◽  
Author(s):  
Lee R. Hagey ◽  
Daniel Odell ◽  
Steven S. Rossi ◽  
Diane L. Crombie ◽  
Alan F. Hofmann
Keyword(s):  
Bile Acid ◽  
Acid Composition ◽  
Sperm Whales ◽  
Biliary Bile Acid

Effect of Ursodeoxycholic Acid on Biliary Bile Acid and Bile Lipid Composition in Gallstone Patients

Hepatology ◽  
1984 ◽  
Vol 4 (1) ◽  
pp. 107-111 ◽  
Author(s):  
Adolf Stiehl ◽  
Richard Raedsch ◽  
Gerda Rudolph ◽  
Siegfried Walker
Keyword(s):  
Bile Acid ◽  
Ursodeoxycholic Acid ◽  
Lipid Composition ◽  
Biliary Bile Acid
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