Reactive Nitrogen and Oxygen Species Metabolism in Rat Heart Mitochondria under Administration of Nitric Oxide Donor in Vivo

2012 ◽  
Vol 3 (4) ◽  
pp. 327-340
Author(s):  
Olga V. Akopova ◽  
Yulia P. Korkach ◽  
Anatolii V. Kotsuruba ◽  
Lyudmila I. Kolchinskaya ◽  
Vadim F. Sagach
Keyword(s):  
Nitric Oxide ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Nitric Oxide Donor ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Rat Heart Mitochondria

scholarly journals Reactive nitrogen and oxygen species metabolism in rat heart mitochondria upon administration of NO donor in vivo

2012 ◽  
Vol 58 (2) ◽  
pp. 3-15 ◽  
Author(s):  
OV Akopova ◽  
◽  
IuP Korkach ◽  
AV Kotsiuruba ◽  
LI Kolchyns'ka ◽  
...  
Keyword(s):  
Rat Heart ◽  
Heart Mitochondria ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
No Donor ◽  
Rat Heart Mitochondria

Regulation of the rate of synthesis of nitric oxide by Mg 2+ and hypoxia. Studies in rat heart mitochondria

Amino Acids ◽  
2002 ◽  
Vol 22 (4) ◽  
pp. 381-389 ◽  
Author(s):  
S. Manzo-Ávalos ◽  
V. Pérez-Vázquez ◽  
J. Ramírez ◽  
L. Aguilera-Aguirre ◽  
J. C. González-Hernández ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Rat Heart Mitochondria

Noradrenaline Protects In Vivo Rat Heart Against Infarction and Ventricular Arrhythmias Via Nitric Oxide and Reactive Oxygen Species

2011 ◽  
Vol 169 (1) ◽  
pp. 9-15 ◽  
Author(s):  
Alireza Imani ◽  
Mahdieh Faghihi ◽  
Sayyed Shahabeddin Sadr ◽  
Somayeh Sadeghi Niaraki ◽  
Ali Mohammad Alizadeh
Keyword(s):  
Nitric Oxide ◽  
Reactive Oxygen Species ◽  
Rat Heart ◽  
Ventricular Arrhythmias ◽  
Reactive Oxygen ◽  
Oxygen Species ◽  
In Vivo Rat Heart

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 ◽  
Vol 328 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Juan José Poderoso ◽  
Marı́a Cecilia Carreras ◽  
Constanza Lisdero ◽  
Natalia Riobó ◽  
Francisco Schöpfer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Electron Transfer ◽  
Rat Heart ◽  
Superoxide Radical ◽  
Heart Mitochondria ◽  
Submitochondrial Particles ◽  
Radical Production ◽  
Rat Heart Mitochondria

scholarly journals The effect of lead on the calcium-handling capacity of rat heart mitochondria

1976 ◽  
Vol 158 (2) ◽  
pp. 289-294 ◽  
Author(s):  
D R Parr ◽  
E J Harris
Keyword(s):  
Rat Heart ◽  
Heart Tissue ◽  
Calcium Handling ◽  
Primary Effect ◽  
Heart Mitochondria ◽  
Excitation Contraction Coupling ◽  
Contraction Coupling ◽  
Low Concentrations ◽  
Rat Heart Mitochondria

1. Very low concentrations of Pb2+ decrease the capacity of rat heart mitochondria, oxidizing pyruvate plus malate, to remove Ca2+ from the medium. 2. The primary effect is on the rate of Ca2+ sequestration; this is reflected in the overall extent of Ca2+ removal. 3. Pb2+ has at least two separate actions. Below about 0.5 nmol/mg of protein, it acts solely by competing with Ca2+ (Ki = 0.4 muM); above this concentration it also inhibits the production or use of respiratory energy, so that at 1 nmol of Pb2+/mg of protein, Ca2+ removal is almost completely abolished. 4. Pb2+ inhibits coupled and uncoupled respiratory O2 use by mitochondria oxidizing pyruvate plus malate, but at higher concentrations than those that affect Ca2+ removal; similar concentrations of Pb2+ inhibit pyruvate uptake, but not malate uptake, by the mitochondria. 5. Mg2+ only decreases Ca2+ removal by competition, and is a far-less effective competitor than Pb2+ (Ki = 0.15 mM). It is possible that the primary cause of the second effect of Pb2+ is displacement of membrane Mg2+. 6. The consequences of these results are discussed in terms of the possible involvement of heart mitochondria in excitation-contraction coupling, and the Pb2+ levels that might occur in heart tissue in vivo.

Increased uncoupling proteins and decreased efficiency in palmitate-perfused hyperthyroid rat heart

2001 ◽  
Vol 280 (3) ◽  
pp. H977-H983 ◽  
Author(s):  
Ernest A. Boehm ◽  
Barney E. Jones ◽  
George K. Radda ◽  
Richard L. Veech ◽  
Kieran Clarke
Keyword(s):  
Rat Heart ◽  
Physiological Role ◽  
Physiological Effect ◽  
Uncoupling Proteins ◽  
Heart Mitochondria ◽  
Acid Oxidation ◽  
Mitochondrial Uncoupling ◽  
Myocardial Efficiency ◽  
Rat Heart Mitochondria

The physiological role of mitochondrial uncoupling proteins (UCPs) in heart and skeletal muscle is unknown, as is whether mitochondrial uncoupling of oxidative phosphorylation by fatty acids occurs in vivo. In this study, we found that UCP2 and UCP3 protein content, determined using Western blotting, was increased by 32 and 48%, respectively, in hyperthyroid rat heart mitochondria. Oligomycin-insensitive respiration rate, a measure of mitochondrial uncoupling, was increased in all mitochondria in the presence of palmitate: 36% in controls and 71 and 100% with 0.8 and 0.9 mM palmitate, respectively, in hyperthyroid rat heart mitochondria. In the isolated working heart, 0.4 mM palmitate significantly lowered cardiac output by 36% and cardiac efficiency by 38% in the hyperthyroid rat heart. Thus increased mitochondrial UCPs in the hyperthyroid rat heart were associated with increased uncoupling and decreased myocardial efficiency in the presence of palmitate. In conclusion, a physiological effect of UCPs on fatty acid oxidation has been found in heart at the mitochondrial and whole organ level.

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