Regulation of the rate of synthesis of nitric oxide by Mg 2+ and hypoxia. Studies in rat heart mitochondria

Amino Acids ◽  
2002 ◽  
Vol 22 (4) ◽  
pp. 381-389 ◽  
Author(s):  
S. Manzo-Ávalos ◽  
V. Pérez-Vázquez ◽  
J. Ramírez ◽  
L. Aguilera-Aguirre ◽  
J. C. González-Hernández ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Rat Heart Mitochondria

Nitric Oxide Inhibits Electron Transfer and Increases Superoxide Radical Production in Rat Heart Mitochondria and Submitochondrial Particles

1996 ◽  
Vol 328 (1) ◽  
pp. 85-92 ◽  
Author(s):  
Juan José Poderoso ◽  
Marı́a Cecilia Carreras ◽  
Constanza Lisdero ◽  
Natalia Riobó ◽  
Francisco Schöpfer ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Electron Transfer ◽  
Rat Heart ◽  
Superoxide Radical ◽  
Heart Mitochondria ◽  
Submitochondrial Particles ◽  
Radical Production ◽  
Rat Heart Mitochondria

Reactive Nitrogen and Oxygen Species Metabolism in Rat Heart Mitochondria under Administration of Nitric Oxide Donor in Vivo

2012 ◽  
Vol 3 (4) ◽  
pp. 327-340
Author(s):  
Olga V. Akopova ◽  
Yulia P. Korkach ◽  
Anatolii V. Kotsuruba ◽  
Lyudmila I. Kolchinskaya ◽  
Vadim F. Sagach
Keyword(s):  
Nitric Oxide ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Nitric Oxide Donor ◽  
Reactive Nitrogen ◽  
Oxygen Species ◽  
Rat Heart Mitochondria

Magnolol and honokiol isolated from magnolia officinalis protect rat heart mitochondria against lipid peroxidation

1994 ◽  
Vol 47 (3) ◽  
pp. 549-553 ◽  
Author(s):  
Yu-Chiang Lo ◽  
Teng Che-Ming ◽  
Chen Chieh-Fu ◽  
Chen Chien-Chih ◽  
Hong Chuang-Ye
Keyword(s):  
Lipid Peroxidation ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Rat Heart Mitochondria ◽  
Magnolia Officinalis

Involvement of SH-groups during interaction of diazoxide with the inner membrane of rat heart mitochondria

2007 ◽  
Vol 415 (1) ◽  
pp. 206-210 ◽  
Author(s):  
S. M. Korotkov ◽  
V. P. Nesterov ◽  
L. V. Emel’yanova ◽  
N. N. Ryabchikov
Keyword(s):  
Rat Heart ◽  
Heart Mitochondria ◽  
Inner Membrane ◽  
Sh Groups ◽  
Rat Heart Mitochondria

Abstract 104: Effects of Pinacidil and Ca 2 + on Sodium-loaded Rat Heart Mitochondria

2013 ◽  
Vol 113 (suppl_1) ◽  
Author(s):  
Sergey M Korotkov ◽  
Vladimir P Nesterov ◽  
Irina V Brailovskaya ◽  
Larisa V Emelyanova ◽  
Svetlana A Konovalova ◽  
...  
Keyword(s):  
Oxygen Consumption ◽  
Rat Heart ◽  
Mitochondrial Membrane ◽  
Mitochondrial Permeability Transition ◽  
Ischemia Reperfusion ◽  
Potassium Acetate ◽  
Heart Mitochondria ◽  
Inner Mitochondrial Membrane ◽  
Rat Heart Mitochondria ◽  
Acetate Medium

Deterioration of the contractile parameters of the heart muscle caused by ischemia and followed reperfusion is known as the main postoperative complication which is related to Ca 2+ and Na + overload in cardiomyocytes and mitochondria. Pinacidil reduced the overload in ischemia/reperfusion experiments. The mechanism of this phenomenon is still not clear. We hypothesized that increased ion permeability of the inner mitochondrial membrane (IMM) followed drop of electrochemical potential (ΔΨ mito ) can reduce the calcium. The aim of the study was to elucidate the effect of pinacidil (100 μM) and Ca 2+ (100 μM ) on swelling, oxygen consumption and ΔΨ mito of isolated sodium-loaded rat heart mitochondria (RHM(Na)) energized glutamate and malate. Pinacidil significantly enchanced the permeability of IMM to protons in ammonium nitrate medium. Also increased swelling of RHM(Na) energized with substrates in potassium acetate medium revealed that pinacidil increased potassium transport into matrix. Pinacidil stimulated oxygen consumption of RHM(Na) in State 4 and detained Ca 2+ -induced dissipation of ΔΨ mito . Under condition of Ca 2+ and Na + overload simulating ischemia/reperfusion, RHM(Na) oxygen consumption was not affected with pinacidil in State 3 and in the presence of 2,4-dinitrophenol. Cyclosporin A and ADP, the inhibitors of mitochondrial permeability transition pore (MPTP), markedly decreased Ca 2+ - induced swelling of RHM(Na) in nitrate ammonium or potassium acetate medium in the presence of pinacidil. Carboxyatractyloside, an inhibitor of cytosolic side-specific adenine nucleotide translocase, eliminated a pinacidil-stimulated oxygen consumption of succinate-energized RHMNa in State 4 regardless of the presence of Ca 2+ . Pinacidil was also concluded to accelerat potassium flux into energized RHM(Na) and promot MPTP opening in the low conduction state. Based on our data we suggested that the effect of pharmacological preconditioning induced by pinacidil could be due to it’s direct effect on mitochondria which is connected with above stimulation of the potassium permeability of the inner mitochondrial membrane and following reduce of the ΔΨ mito that thus prevent calcium overload of cardiomyocytes after ischemia/reperfusion in turn.

Structure of paracrystalline arrays on outer membranes of rat-liver and rat-heart mitochondria

1992 ◽  
Vol 108 (3) ◽  
pp. 227-237 ◽  
Author(s):  
C.A. Mannella ◽  
A. Ribeiro ◽  
B. Cognon ◽  
D. D'Arcangelis
Keyword(s):  
Rat Liver ◽  
Rat Heart ◽  
Heart Mitochondria ◽  
Outer Membranes ◽  
Rat Heart Mitochondria
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