scholarly journals A3 Adenosine Receptors Modulate Hypoxia-inducible Factor-1a Expression in Human A375 Melanoma Cells

Neoplasia ◽  
2005 ◽  
Vol 7 (10) ◽  
pp. 894-903 ◽  
Author(s):  
Stefania Merighi ◽  
Annalisa Benini ◽  
Prisco Mirandola ◽  
Stefania Gessi ◽  
Katia Varani ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Hypoxia Inducible Factor ◽  
Melanoma Cells ◽  
A375 Melanoma

Active interaction of human A375 melanoma cells with the lymphatics in vivo

2000 ◽  
Vol 114 (5) ◽  
pp. 373-385 ◽  
Author(s):  
Maria Papoutsi ◽  
Gerhard Siemeister ◽  
Karin Weindel ◽  
Stanislav I. Tomarev ◽  
Haymo Kurz ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Active Interaction ◽  
A375 Melanoma

scholarly journals Bornyl cis-4-Hydroxycinnamate Suppresses Cell Metastasis of Melanoma through FAK/PI3K/Akt/mTOR and MAPK Signaling Pathways and Inhibition of the Epithelial-to-Mesenchymal Transition

2018 ◽  
Vol 19 (8) ◽  
pp. 2152 ◽  
Author(s):  
Tzu-Yen Yang ◽  
Mei-Li Wu ◽  
Chi-I Chang ◽  
Chih-I Liu ◽  
Te-Chih Cheng ◽  
...  
Keyword(s):  
Cell Migration ◽  
Signaling Pathways ◽  
Melanoma Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Melanoma Cells ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Cell Migration And Invasion ◽  
Cell Metastasis ◽  
A375 Melanoma

Bornyl cis-4-hydroxycinnamate, a bioactive compound isolated from Piper betle stems, has the potential for use as an anti-cancer agent. This study investigated the effects of bornyl cis-4-hydroxycinnamate on cell migration and invasion in melanoma cells. Cell migration and invasion were compared in A2058 and A375 melanoma cell lines treated with/without bornyl cis-4-hydroxycinnamate (1–6 µM). To examine whether bornyl cis-4-hydroxycinnamate has a potential anti-metastatic effect on melanoma cells, cell migration and invasion assays were performed using a Boyden chamber assay and a transwell chamber in A2058 and A375 cells. Gelatin zymography was employed to determine the enzyme activities of MMP-2 and MMP-9. Cell lysates were collected for Western blotting analysis of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitors of metalloproteinase-1/2 (TIMP-1/2), as well as key molecules in the mitogen-activated protein kinase (MAPK), focal adhesion kinase (FAK)/ phosphatidylinositide-3 kinases (PI3K)/Akt/ mammalian target of rapamycin (mTOR), growth factor receptor-bound protein 2 (GRB2) signaling pathways. Our results demonstrated that bornyl cis-4-hydroxycinnamate is a potentially useful agent that inhibits melanoma cell migration and invasion, and altered melanoma cell metastasis by reducing MMP-2 and MMP-9 expression through inhibition of the FAK/PI3K/Akt/mTOR, MAPK, and GRB2 signaling pathways. Moreover, bornyl cis-4-hydroxycinnamate inhibited the process of the epithelial-to-mesenchymal transition in A2058 and A375 melanoma cells. These findings suggested that bornyl cis-4-hydroxycinnamate has potential as a chemotherapeutic agent, and warrants further investigation for its use in the management of human melanoma.

A1 and A3 adenosine receptors inhibit LPS-induced hypoxia-inducible factor-1 accumulation in murine astrocytes

2013 ◽  
Vol 76 ◽  
pp. 157-170 ◽  
Author(s):  
Stefania Gessi ◽  
Stefania Merighi ◽  
Angela Stefanelli ◽  
Debora Fazzi ◽  
Katia Varani ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Hypoxia Inducible Factor ◽  
Hypoxia Inducible Factor 1

scholarly journals Interaction of extracellular S100A4 with RAGE prompts prometastatic activation of A375 melanoma cells

2016 ◽  
Vol 20 (5) ◽  
pp. 825-835 ◽  
Author(s):  
Nadine Herwig ◽  
Birgit Belter ◽  
Susann Wolf ◽  
Cathleen Haase‐Kohn ◽  
Jens Pietzsch
Keyword(s):  
Melanoma Cells ◽  
A375 Melanoma

Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid–nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells

Nitric Oxide ◽  
2008 ◽  
Vol 19 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Sanja Mijatovic ◽  
Danijela Maksimovic-Ivanic ◽  
Marija Mojic ◽  
Graziella Malaponte ◽  
Massimo Libra ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acetic Acid ◽  
Melanoma Cells ◽  
A375 Melanoma

CSMD1 exhibits antitumor activity in A375 melanoma cells through activation of the Smad pathway

APOPTOSIS ◽  
2012 ◽  
Vol 17 (9) ◽  
pp. 927-937 ◽  
Author(s):  
Ming-Rui Tang ◽  
Yu-Xin Wang ◽  
Shu Guo ◽  
Si-Yuan Han ◽  
Di Wang
Keyword(s):  
Antitumor Activity ◽  
Melanoma Cells ◽  
Smad Pathway ◽  
A375 Melanoma

scholarly journals RedOx Status, Proteasome and APEH: Insights into Anticancer Mechanisms of t10,c12-Conjugated Linoleic Acid Isomer on A375 Melanoma Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80900 ◽  
Author(s):  
Paolo Bergamo ◽  
Ennio Cocca ◽  
Rosanna Palumbo ◽  
Marta Gogliettino ◽  
Mose Rossi ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Redox Status ◽  
Melanoma Cells ◽  
Conjugated Linoleic Acid Isomer ◽  
Linoleic Acid Isomer ◽  
A375 Melanoma

MSH Receptors and the Response of Human A375 Melanoma Cells to Interleukin-1β

1997 ◽  
Vol 17 (1-3) ◽  
pp. 199-210 ◽  
Author(s):  
Joyce B. Baumann ◽  
Claudia Bagutti ◽  
Walter Siegrist ◽  
Elli Christen ◽  
Urs Zumsteg ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Interleukin 1Β ◽  
A375 Melanoma
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