scholarly journals Interaction of extracellular S100A4 with RAGE prompts prometastatic activation of A375 melanoma cells

2016 ◽  
Vol 20 (5) ◽  
pp. 825-835 ◽  
Author(s):  
Nadine Herwig ◽  
Birgit Belter ◽  
Susann Wolf ◽  
Cathleen Haase‐Kohn ◽  
Jens Pietzsch
Keyword(s):  
Melanoma Cells ◽  
A375 Melanoma

Active interaction of human A375 melanoma cells with the lymphatics in vivo

2000 ◽  
Vol 114 (5) ◽  
pp. 373-385 ◽  
Author(s):  
Maria Papoutsi ◽  
Gerhard Siemeister ◽  
Karin Weindel ◽  
Stanislav I. Tomarev ◽  
Haymo Kurz ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Active Interaction ◽  
A375 Melanoma

scholarly journals Bornyl cis-4-Hydroxycinnamate Suppresses Cell Metastasis of Melanoma through FAK/PI3K/Akt/mTOR and MAPK Signaling Pathways and Inhibition of the Epithelial-to-Mesenchymal Transition

2018 ◽  
Vol 19 (8) ◽  
pp. 2152 ◽  
Author(s):  
Tzu-Yen Yang ◽  
Mei-Li Wu ◽  
Chi-I Chang ◽  
Chih-I Liu ◽  
Te-Chih Cheng ◽  
...  
Keyword(s):  
Cell Migration ◽  
Signaling Pathways ◽  
Melanoma Cell ◽  
Epithelial To Mesenchymal Transition ◽  
Melanoma Cells ◽  
Migration And Invasion ◽  
Mesenchymal Transition ◽  
Cell Migration And Invasion ◽  
Cell Metastasis ◽  
A375 Melanoma

Bornyl cis-4-hydroxycinnamate, a bioactive compound isolated from Piper betle stems, has the potential for use as an anti-cancer agent. This study investigated the effects of bornyl cis-4-hydroxycinnamate on cell migration and invasion in melanoma cells. Cell migration and invasion were compared in A2058 and A375 melanoma cell lines treated with/without bornyl cis-4-hydroxycinnamate (1–6 µM). To examine whether bornyl cis-4-hydroxycinnamate has a potential anti-metastatic effect on melanoma cells, cell migration and invasion assays were performed using a Boyden chamber assay and a transwell chamber in A2058 and A375 cells. Gelatin zymography was employed to determine the enzyme activities of MMP-2 and MMP-9. Cell lysates were collected for Western blotting analysis of matrix metalloproteinase (MMP)-2, MMP-9 and tissue inhibitors of metalloproteinase-1/2 (TIMP-1/2), as well as key molecules in the mitogen-activated protein kinase (MAPK), focal adhesion kinase (FAK)/ phosphatidylinositide-3 kinases (PI3K)/Akt/ mammalian target of rapamycin (mTOR), growth factor receptor-bound protein 2 (GRB2) signaling pathways. Our results demonstrated that bornyl cis-4-hydroxycinnamate is a potentially useful agent that inhibits melanoma cell migration and invasion, and altered melanoma cell metastasis by reducing MMP-2 and MMP-9 expression through inhibition of the FAK/PI3K/Akt/mTOR, MAPK, and GRB2 signaling pathways. Moreover, bornyl cis-4-hydroxycinnamate inhibited the process of the epithelial-to-mesenchymal transition in A2058 and A375 melanoma cells. These findings suggested that bornyl cis-4-hydroxycinnamate has potential as a chemotherapeutic agent, and warrants further investigation for its use in the management of human melanoma.

scholarly journals A3 Adenosine Receptors Modulate Hypoxia-inducible Factor-1a Expression in Human A375 Melanoma Cells

Neoplasia ◽  
2005 ◽  
Vol 7 (10) ◽  
pp. 894-903 ◽  
Author(s):  
Stefania Merighi ◽  
Annalisa Benini ◽  
Prisco Mirandola ◽  
Stefania Gessi ◽  
Katia Varani ◽  
...  
Keyword(s):  
Adenosine Receptors ◽  
Hypoxia Inducible Factor ◽  
Melanoma Cells ◽  
A375 Melanoma

Novel nitric oxide-donating compound (S,R)-3-phenyl-4,5-dihydro-5-isoxazole acetic acid–nitric oxide (GIT-27NO) induces p53 mediated apoptosis in human A375 melanoma cells

Nitric Oxide ◽  
2008 ◽  
Vol 19 (2) ◽  
pp. 177-183 ◽  
Author(s):  
Sanja Mijatovic ◽  
Danijela Maksimovic-Ivanic ◽  
Marija Mojic ◽  
Graziella Malaponte ◽  
Massimo Libra ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Acetic Acid ◽  
Melanoma Cells ◽  
A375 Melanoma

CSMD1 exhibits antitumor activity in A375 melanoma cells through activation of the Smad pathway

APOPTOSIS ◽  
2012 ◽  
Vol 17 (9) ◽  
pp. 927-937 ◽  
Author(s):  
Ming-Rui Tang ◽  
Yu-Xin Wang ◽  
Shu Guo ◽  
Si-Yuan Han ◽  
Di Wang
Keyword(s):  
Antitumor Activity ◽  
Melanoma Cells ◽  
Smad Pathway ◽  
A375 Melanoma

scholarly journals RedOx Status, Proteasome and APEH: Insights into Anticancer Mechanisms of t10,c12-Conjugated Linoleic Acid Isomer on A375 Melanoma Cells

PLoS ONE ◽  
2013 ◽  
Vol 8 (11) ◽  
pp. e80900 ◽  
Author(s):  
Paolo Bergamo ◽  
Ennio Cocca ◽  
Rosanna Palumbo ◽  
Marta Gogliettino ◽  
Mose Rossi ◽  
...  
Keyword(s):  
Linoleic Acid ◽  
Conjugated Linoleic Acid ◽  
Redox Status ◽  
Melanoma Cells ◽  
Conjugated Linoleic Acid Isomer ◽  
Linoleic Acid Isomer ◽  
A375 Melanoma

MSH Receptors and the Response of Human A375 Melanoma Cells to Interleukin-1β

1997 ◽  
Vol 17 (1-3) ◽  
pp. 199-210 ◽  
Author(s):  
Joyce B. Baumann ◽  
Claudia Bagutti ◽  
Walter Siegrist ◽  
Elli Christen ◽  
Urs Zumsteg ◽  
...  
Keyword(s):  
Melanoma Cells ◽  
Interleukin 1Β ◽  
A375 Melanoma

scholarly journals Dual, enzymatic and non-enzymatic, function of ecto-5'-nucleotidase (eN, CD73) in migration and invasion of A375 melanoma cells.

2012 ◽  
Vol 59 (4) ◽  
Author(s):  
Rafal Sadej ◽  
Andrzej C Skladanowski
Keyword(s):  
Cell Interaction ◽  
Melanoma Cells ◽  
Migration And Invasion ◽  
Extracellular Adenosine ◽  
Enzymatic Function ◽  
Ecm Proteins ◽  
A375 Melanoma ◽  
Formation Of Complexes ◽  
Strength Of Adhesion

Ecto-5'-nucleotidase (eN, CD73) mediates extracellular adenosine production from 5'-AMP. Non-enzymatic functions of eN have also been reported. The aim of the study was to investigate the role of ecto-5'-nucleotidase in aggressive melanoma behaviour. Analysis of the involvement of eN in adhesion, migration and invasion revealed eN functions unknown to date. We found that following eN blockade by concanavalin A, the strength of adhesion to different ECM proteins was not altered, but at the same time the invasion ability of the cells was decreased. On the other hand, knocking down eN in melanoma cells did not influence cell invasion but abolished their migration on tenascin C (TnC). Ecto-5'-nucleotidase seems to fulfil a more distinct role as a receptor than as an enzyme in the cell interaction and mobility on TnC. Ecto-5'-nucleotidase activates also focal adhesion kinase and enhances the formation of complexes upon cell adhesion to TnC. All these observations prove that an eN-TnC complex is involved in cell migration and invasion and thus in the regulation of melanoma progression.

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