scholarly journals Parthenolide regulates DNMT1-mediated methylation of VDR promoter to relieve podocyte damage in mice with diabetic nephropathy

2021 ◽  
Author(s):  
Xinbo YANG ◽  
Yulei ZHANG ◽  
Ni YANG ◽  
Xiao YU ◽  
Xin GAO ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Podocyte Damage

Inhibition of NLRP3 inflammasome ameliorates podocyte damage by suppressing lipid accumulation in diabetic nephropathy

Metabolism ◽  
2021 ◽  
Vol 118 ◽  
pp. 154748
Author(s):  
Ming Wu ◽  
Zhifen Yang ◽  
Chengyu Zhang ◽  
Yu Shi ◽  
Weixia Han ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Nlrp3 Inflammasome ◽  
Lipid Accumulation ◽  
Podocyte Damage

scholarly journals Podocyte-specific Rac1 deficiency ameliorates podocyte damage and proteinuria in STZ-induced diabetic nephropathy in mice

2018 ◽  
Vol 9 (3) ◽  
Author(s):  
Zhimei Lv ◽  
Mengsi Hu ◽  
Minghua Fan ◽  
Xiaobing Li ◽  
Jiangong Lin ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Podocyte Damage

scholarly journals Inhibition of miR-17~92 Cluster Ameliorates High Glucose-Induced Podocyte Damage

2020 ◽  
Vol 2020 ◽  
pp. 1-12
Author(s):  
Xiaobao Fan ◽  
Zhiming Hao ◽  
Zhenjiang Li ◽  
Xiaoming Wang ◽  
Jing Wang
Keyword(s):  
Diabetic Nephropathy ◽  
Kidney Disease ◽  
High Glucose ◽  
Bioinformatics Analysis ◽  
Polycystic Kidney ◽  
Podocyte Damage ◽  
Atp Binding Cassette Transporter ◽  
Biopsy Tissue ◽  
Loss And Damage

The loss and damage of podocytes is an early feature of diabetic nephropathy (DN). The miR-17∼92 cluster was dysregulated in diabetic and polycystic kidney disease patients, but its role in DN is unclear. Hence, an in vitro study on the high glucose- (HG-) treated mouse podocytes (MPC5) was designed to elucidate the effect of miR-17∼92 cluster downregulation on cell viability, apoptosis, inflammation, fibrosis, and podocyte function. The results suggested that the miR-17∼92 cluster members miR-17-5p, miR-18a, miR-19a, miR-19b, miR-20a, and miR-92a were upregulated in the renal biopsy tissue of DN patients and HG-treated MPC5. The downregulation of the miR-17∼92 cluster effectively suppressed the cell apoptosis, inflammation, fibrosis, and podocyte dysfunction in HG-stimulated MPC5 cells. The bioinformatics analysis and rescue experiments showed that ABCA1 (ATP-binding cassette transporter A1) is an effector of the miR-17~92 cluster. Silence of ABCA1 inhibited the protective effect of the miR-17∼92 cluster downregulation on podocyte damage. In summary, this research indicated that the downregulation of the miR-17∼92 cluster ameliorates HG-induced podocyte damage via targeting ABCA1.

scholarly journals Silencing of long noncoding RNA PVT1 inhibits podocyte damage and apoptosis in diabetic nephropathy by upregulating FOXA1

2019 ◽  
Vol 51 (8) ◽  
pp. 1-15 ◽  
Author(s):  
Dong-Wei Liu ◽  
Jia-Hui Zhang ◽  
Feng-Xun Liu ◽  
Xu-Tong Wang ◽  
Shao-Kang Pan ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Long Noncoding Rna ◽  
Noncoding Rna ◽  
Podocyte Damage

scholarly journals Mesenchymal Stem Cell-Based Therapies against Podocyte Damage in Diabetic Nephropathy

2017 ◽  
Vol 14 (3) ◽  
pp. 201-210 ◽  
Author(s):  
Manizheh Khalilpourfarshbafi ◽  
Fatemeh Hajiaghaalipour ◽  
Kesavanarayanan Krishnan Selvarajan ◽  
Aishah Adam
Keyword(s):  
Diabetic Nephropathy ◽  
Stem Cell ◽  
Mesenchymal Stem Cell ◽  
Podocyte Damage

Abstract # P-17: Association of NQO1 (Rs1800566) Polymorphism with NQO1 Levels and Risk of Diabetic Nephropathy in Indian Population

2016 ◽  
Vol 22 ◽  
pp. 21
Author(s):  
Mohini Sharma ◽  
S. Gupta ◽  
M. Mehndiratta ◽  
O.P. Kalra ◽  
R. Shukla ◽  
...  
Keyword(s):  
Diabetic Nephropathy ◽  
Indian Population
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