scholarly journals Clinic serum levels of Plin5 is therapeutic target of spinal cord injury and Plin5 reduced inflammation in spinal cord injury via silent information regulator 1 dependent inhibition of NLRP3 inflammasome

2021 ◽  
Author(s):  
Binqiang WU ◽  
Xiao LIANG ◽  
Feng ZHAO ◽  
Wei FAN ◽  
Chunjiang LI ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nlrp3 Inflammasome ◽  
Therapeutic Target ◽  
Serum Levels ◽  
Cord Injury ◽  
Dependent Inhibition ◽  
Silent Information Regulator 1

Inflammatory Response and Cell Apoptosis are Inhibited by Indirubin-3′-Oxime via PI3K/Akt Pathway in Rat Model of Spinal Cord Injury ​

2020 ◽  
Author(s):  
Yan Zhu ◽  
Lixue Wu ◽  
Qiuxiang Zhou ◽  
Yueyue Yan ◽  
Jinlong Qu ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Serum Levels ◽  
Motor Dysfunction ◽  
Akt Phosphorylation ◽  
Treatment Groups ◽  
Ppar Γ ◽  
Post Surgery ◽  
Cord Injury

Abstract Spinal cord injury (SCI) main cause of motor dysfunction results in loss of feelings partially or completely. The current study investigated indirubin-3′-oxime (IR3O) for treatment of SCI in rat model and evaluated the related mechanism. Rats in model SCI and ID30 groups were subjected to laminectomy at 8th thoracic vertebra level. Vertebral column was secured by clamping T6 and T10 and SCI model was established by dripping a hammer. Treatment groups received 0.25, 0.5, 0.75 and 1.0 mg/kg doses of ID30 daily for 2-weeks post-surgery. Treatment with ID30 effectively improved BBB score in rats with SCI in dose-based manner. Accumulation of water in spinal cord tissues was alleviated significantly on treatment of SCI rats with ID30. ID30 treatment significantly alleviated SCI mediated higher serum levels of TNF-α and cytokines (IL-1β and IL-6) in SCI rats. In ID30 treated SCI rats SOD, CAT and GSH activities were significantly alleviated. The SCI mediated increased cleaved caspase-3 and -9 levels were alleviated by ID30 treatment significantly. Moreover, ID30 treatment suppressed SCI mediated elevation of PGE2, COX‑2 levels and significantly (P<0.05) elevated PPAR-γ expression. The ID30 treatment of SCI rats significantly (P<0.05) elevated PI3K and Akt phosphorylation. Thus, ID30 inhibited edema and improved BBB score in rats with SCI by targeting pro-inflammatory cytokines and oxidative response. Moreover, in SCI rats ID30 treatment down-regulated apoptotic proteins, promoted PPAR-γ activation and elevated PI3K/Akt phosphorylation. Thus, ID30 has potential to be studied further for development of therapeutic strategy for SCI.

Diagnostic Value of Serum Levels of GFAP, pNF-H, and NSE Compared With Clinical Findings in Severity Assessment of Human Traumatic Spinal Cord Injury

Spine ◽  
2015 ◽  
Vol 40 (14) ◽  
pp. E823-E830 ◽  
Author(s):  
Reza Ahadi ◽  
Fariba Khodagholi ◽  
Abdolhadi Daneshi ◽  
Ali Vafaei ◽  
Amir Ali Mafi ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Serum Levels ◽  
Diagnostic Value ◽  
Clinical Findings ◽  
Traumatic Spinal Cord Injury ◽  
Severity Assessment ◽  
Cord Injury

scholarly journals Complement Plays an Important Role in Spinal Cord Injury and Represents a Therapeutic Target for Improving Recovery following Trauma

2006 ◽  
Vol 169 (3) ◽  
pp. 1039-1047 ◽  
Author(s):  
Fei Qiao ◽  
Carl Atkinson ◽  
Hongbin Song ◽  
Ravinder Pannu ◽  
Inderjit Singh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Target ◽  
Cord Injury

scholarly journals Cytosolic phospholipase A 2 protein as a novel therapeutic target for spinal cord injury

2014 ◽  
Vol 75 (5) ◽  
pp. 644-658 ◽  
Author(s):  
Nai‐Kui Liu ◽  
Ling‐Xiao Deng ◽  
Yi Ping Zhang ◽  
Qing‐Bo Lu ◽  
Xiao‐Fei Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Target ◽  
Phospholipase A ◽  
Cytosolic Phospholipase ◽  
Cord Injury ◽  
Novel Therapeutic ◽  
Phospholipase A 2

scholarly journals Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice

2017 ◽  
Vol 14 (1) ◽  
Author(s):  
Wu Jiang ◽  
Maoqiang Li ◽  
Fan He ◽  
Shaobo Zhou ◽  
Liulong Zhu
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Nlrp3 Inflammasome ◽  
Cord Injury

scholarly journals Stem Cells in Spinal Cord Injury

2008 ◽  
Vol 24 (4-5) ◽  
pp. 239-250 ◽  
Author(s):  
Jean R. Wrathall ◽  
Judith M. Lytle
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Therapeutic Target ◽  
Proliferative Response ◽  
Traumatic Injury ◽  
Functional Deficits ◽  
Cord Injury ◽  
Adult Spinal Cord

Traumatic injury to the adult spinal cord results in a massive loss of cells and permanent functional deficits. However, recent studies demonstrate that there is a proliferative response of endogenous glial precursors and progenitors and perhaps also pluripotent neural stem cells. These cells may prove to be an important new therapeutic target to improve recovery after injury to the spinal cord and brain.

Fasting Serum Levels of Adiponectin, Ghrelin, and Leptin in Men With Spinal Cord Injury

2005 ◽  
Vol 86 (10) ◽  
pp. 1964-1968 ◽  
Author(s):  
Yen-Ho Wang ◽  
Tien-Shang Huang ◽  
Huey-Wen Liang ◽  
Ta-Chen Su ◽  
Ssu-Yuan Chen ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Serum Levels ◽  
Fasting Serum ◽  
Cord Injury
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