scholarly journals Cytosolic phospholipase A 2 protein as a novel therapeutic target for spinal cord injury

2014 ◽  
Vol 75 (5) ◽  
pp. 644-658 ◽  
Author(s):  
Nai‐Kui Liu ◽  
Ling‐Xiao Deng ◽  
Yi Ping Zhang ◽  
Qing‐Bo Lu ◽  
Xiao‐Fei Wang ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Target ◽  
Phospholipase A ◽  
Cytosolic Phospholipase ◽  
Cord Injury ◽  
Novel Therapeutic ◽  
Phospholipase A 2

scholarly journals Phospholipase A 2 superfamily members play divergent roles after spinal cord injury

2011 ◽  
Vol 25 (12) ◽  
pp. 4240-4252 ◽  
Author(s):  
Rubèn López‐Vales ◽  
Nader Ghasemlou ◽  
Adriana Redensek ◽  
Bradley J. Kerr ◽  
Efrosini Barbayianni ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Phospholipase A ◽  
Cord Injury ◽  
Phospholipase A 2

scholarly journals S-Nitrosoglutathione protects the spinal bladder: Novel therapeutic approach to post-spinal cord injury bladder remodeling

2014 ◽  
Vol 34 (6) ◽  
pp. 519-526 ◽  
Author(s):  
Anandakumar Shunmugavel ◽  
Mushfiquddin Khan ◽  
Francis M. Hughes ◽  
J. Todd Purves ◽  
Avtar Singh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Approach ◽  
Cord Injury ◽  
Novel Therapeutic

scholarly journals Complement Plays an Important Role in Spinal Cord Injury and Represents a Therapeutic Target for Improving Recovery following Trauma

2006 ◽  
Vol 169 (3) ◽  
pp. 1039-1047 ◽  
Author(s):  
Fei Qiao ◽  
Carl Atkinson ◽  
Hongbin Song ◽  
Ravinder Pannu ◽  
Inderjit Singh ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Therapeutic Target ◽  
Cord Injury

scholarly journals Stem Cells in Spinal Cord Injury

2008 ◽  
Vol 24 (4-5) ◽  
pp. 239-250 ◽  
Author(s):  
Jean R. Wrathall ◽  
Judith M. Lytle
Keyword(s):  
Spinal Cord ◽  
Stem Cells ◽  
Spinal Cord Injury ◽  
Neural Stem Cells ◽  
Therapeutic Target ◽  
Proliferative Response ◽  
Traumatic Injury ◽  
Functional Deficits ◽  
Cord Injury ◽  
Adult Spinal Cord

Traumatic injury to the adult spinal cord results in a massive loss of cells and permanent functional deficits. However, recent studies demonstrate that there is a proliferative response of endogenous glial precursors and progenitors and perhaps also pluripotent neural stem cells. These cells may prove to be an important new therapeutic target to improve recovery after injury to the spinal cord and brain.

scholarly journals MicroRNA-146a Contributes to SCI Recovery via Regulating TRAF6 and IRAK1 Expression

2016 ◽  
Vol 2016 ◽  
pp. 1-8 ◽  
Author(s):  
Jinsong Wei ◽  
Jiafeng Wang ◽  
Yulan Zhou ◽  
Shouquan Yan ◽  
Keshen Li ◽  
...  
Keyword(s):  
Spinal Cord ◽  
Spinal Cord Injury ◽  
Rat Model ◽  
Proinflammatory Cytokine ◽  
Target Genes ◽  
Sham Group ◽  
Luciferase Assay ◽  
Tight Control ◽  
Cord Injury ◽  
Novel Therapeutic

MicroRNA-146a participates in spinal cord injury (SCI) recovery. Until recently, how miRNA-146a participates in SCI remained unclear. In this study, we tried to explore the roles of miRNA-146a in the recovery of SCI using a rat model. The expression of the probable target genes of miRNA-146a (including IRAK1 and TARF6) as well as proinflammation cytokines were measured until 7 days after surgery in the three groups (sham group, SCI group, and miRNA-146a antagomir injection group). Also, the animals’ motivations were estimated using Basso Beattie Bresnahan (BBB) during the whole experiment. A luciferase assay was performed to demonstrate that miRNA-146a could directly target the mRNAs of IRAK1 and TRAF6. Our experiments indicate that miRNA-146a inhibits proinflammatory cytokine secretion by suppressing IRAK1 and TRAF6 expression in the SCI model. In contrast, miRNA-146a may be upregulated by inflammatory mediators via the IRAK1/TRAF6 pathway in the spinal cord. As a negative feedback element, miRNA-146a could make sure that the expression of IRAK1- and TRAF6-mediated genes was under tight control. Thus, miRNA-146a may serve as a novel therapeutic target for SCI interventions.

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