Role of nitric oxide in the regulation of intraocular pressure: a possibility for glaucoma treatment

2010 ◽  
Vol 5 (6) ◽  
pp. 751-758
Author(s):  
Heikki Vapaatalo ◽  
Hanna Kotikoski ◽  
Olli Oksala
Keyword(s):  
Nitric Oxide ◽  
Intraocular Pressure ◽  
Glaucoma Treatment

Morphine-Induced Reduction of Intraocular Pressure and Pupil Diameter: Role of Nitric Oxide

Pharmacology ◽  
2006 ◽  
Vol 77 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Juanita Dortch-Carnes ◽  
Karen R.M. Russell
Keyword(s):  
Nitric Oxide ◽  
Intraocular Pressure ◽  
Pupil Diameter

scholarly journals Role of 24-Hour Intraocular Pressure Monitoring in Glaucoma Management

2019 ◽  
Vol 2019 ◽  
pp. 1-13
Author(s):  
Chun Hing Ho ◽  
Jasper K. W. Wong
Keyword(s):  
Intraocular Pressure ◽  
Optic Nerve ◽  
Clinical Relevance ◽  
Current Practice ◽  
Normal Tension Glaucoma ◽  
Treatment Modalities ◽  
Pressure Monitoring ◽  
Optic Nerve Damage ◽  
Glaucoma Treatment

Glaucoma is the leading cause of irreversible blindness worldwide and the prevalence is on the rising trend. Intraocular pressure (IOP) reduction is the mainstay of treatment. The current practice of IOP monitoring is based on spot measurements during clinic visits during office hours. However, there are up to 50% of glaucoma patients who had normal initial IOP, while some treated patients continued to have progressive glaucomatous optic nerve damage even with a low IOP. Recent studies have shown that the IOP of glaucoma patients fluctuated during the day with different patterns, and some of them had peak IOP outside office hours. These findings provided us with new insights on the role of 24-hour IOP monitoring in managing normal tension glaucoma and patients with progressive deterioration despite apparently well-controlled IOP. Nevertheless, results to date are rather inconsistent, and there is no consensus yet. In this review, we briefly highlighted the current modalities of 24-hour IOP monitoring and summarized the characteristic 24-hour IOP pattern and the clinical relevance of IOP parameters in predicting glaucomatous progression in different glaucoma subtypes. We also discussed the therapeutic efficacy of current glaucoma treatment modalities with respect to the mentioned 24-hour IOP profiles, so as to strengthen the role of 24-hour IOP monitoring in identifying and stratifying the risks of progression in glaucoma patients, as well as optimizing treatments according to their IOP profiles.

scholarly journals Role of nitric oxide in optic nerve head blood flow regulation during an experimental increase in intraocular pressure in healthy humans

2013 ◽  
Vol 116 ◽  
pp. 247-253 ◽  
Author(s):  
Doreen Schmidl ◽  
Agnes Boltz ◽  
Semira Kaya ◽  
Stefan Palkovits ◽  
Reinhard Told ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Flow Regulation ◽  
Healthy Humans ◽  
Blood Flow Regulation

Comparison of Nitric Oxide Donors in Lowering Intraocular Pressure in Rabbits: Role of Cyclic GMP

2002 ◽  
Vol 18 (1) ◽  
pp. 11-23 ◽  
Author(s):  
Hanna Kotikoski ◽  
Päivi Alajuuma ◽  
Eeva Moilanen ◽  
Pertteli Salmenperä ◽  
Olli Oksala ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Intraocular Pressure ◽  
Cyclic Gmp ◽  
Nitric Oxide Donors

A critical role of iNOS-derived Nitric Oxide (NO) and progesterone in implantation

1998 ◽  
Vol 5 (1) ◽  
pp. 115A-115A
Author(s):  
K CHWALISZ ◽  
E WINTERHAGER ◽  
T THIENEL ◽  
R GARFIELD
Keyword(s):  
Nitric Oxide ◽  
Critical Role
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