scholarly journals The Role of Nitric Oxide in the Intraocular Pressure Lowering Efficacy of Latanoprostene Bunod: Review of Nonclinical Studies

2018 ◽  
Vol 34 (1-2) ◽  
pp. 52-60 ◽  
Author(s):  
Megan E. Cavet ◽  
Heleen H. DeCory
Keyword(s):  
Nitric Oxide ◽  
Intraocular Pressure ◽  
Pressure Lowering

The role of mitomycin C and porcine extracellular matrix in phacotrabeculectomy

2020 ◽  
pp. 112067212094433 ◽  
Author(s):  
Momen Mahmoud Hamdi ◽  
Islam Mahmoud Hamdi
Keyword(s):  
Extracellular Matrix ◽  
Intraocular Pressure ◽  
Mitomycin C ◽  
Low Dose ◽  
Open Angle Glaucoma ◽  
Group Iii ◽  
Group I ◽  
Pressure Lowering ◽  
The Mean

Purpose: To compare between mitomycin C alone, porcine extracellular matrix alone, and combined low dose mitomycin C with porcine extracellular matrix in term of efficacy and safety in phaco-trabeculectomy surgery. Study design: Prospective comparative. Methods: Sixty eyes of 60 patients complaining of primary open angle glaucoma and cataract, undergoing phaco-trabeculectomy, were distributed into three groups: group I: surgery was augmented with mitomycin C, group II with porcine extracellular matrix, and group III with porcine extracellular matrix combined with low dose mitomycin C. Intraocular pressure was evaluated, postoperatively, at day 1, week 1, and 1, 3, 6, 9, and 12 months. Bleb vascularity, pre- and post-operative intraocular pressure lowering medications, success of IOP control and complications were also evaluated. Results: After 12 months, the mean preoperative intraocular pressure (mm Hg) improved from 30.85 ± 4.7, 33.8 ± 4.2, and 31.05 ± 5.4 mm Hg, in groups I, II, and III respectively, to 13.8 ± 4.7 (55.2%), 15.2 ± 4.8 (55%), and 13 ± 4.9 (58.1%) ( p > 0.05). Success of IOP control, postoperative IOP lowering medications and complications were comparable ( p > 0.05). Bleb vascularity was significantly different ( p < 0.05). Conclusion: Mitomycin C, porcine extracellular matrix and their combination are equally effective in phacotrabeculectomy.

Morphine-Induced Reduction of Intraocular Pressure and Pupil Diameter: Role of Nitric Oxide

Pharmacology ◽  
2006 ◽  
Vol 77 (1) ◽  
pp. 17-24 ◽  
Author(s):  
Juanita Dortch-Carnes ◽  
Karen R.M. Russell
Keyword(s):  
Nitric Oxide ◽  
Intraocular Pressure ◽  
Pupil Diameter

scholarly journals Role of nitric oxide in optic nerve head blood flow regulation during an experimental increase in intraocular pressure in healthy humans

2013 ◽  
Vol 116 ◽  
pp. 247-253 ◽  
Author(s):  
Doreen Schmidl ◽  
Agnes Boltz ◽  
Semira Kaya ◽  
Stefan Palkovits ◽  
Reinhard Told ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Blood Flow ◽  
Intraocular Pressure ◽  
Optic Nerve ◽  
Optic Nerve Head ◽  
Flow Regulation ◽  
Healthy Humans ◽  
Blood Flow Regulation

Role of adenosine receptors in resveratrol-induced intraocular pressure lowering in rats with steroid-induced ocular hypertension

2014 ◽  
Vol 43 (1) ◽  
pp. 54-66 ◽  
Author(s):  
Norhafiza Razali ◽  
Renu Agarwal ◽  
Puneet Agarwal ◽  
Sunil Kumar ◽  
Minaketan Tripathy ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Ocular Hypertension ◽  
Adenosine Receptors ◽  
Pressure Lowering

scholarly journals Glial Cells in Glaucoma: Friends, Foes, and Potential Therapeutic Targets

2021 ◽  
Vol 12 ◽  
Author(s):  
Mariana Y. García-Bermúdez ◽  
Kristine K. Freude ◽  
Zaynab A. Mouhammad ◽  
Peter van Wijngaarden ◽  
Keith K. Martin ◽  
...  
Keyword(s):  
Intraocular Pressure ◽  
Glial Cells ◽  
Ganglion Cells ◽  
Treatment Strategies ◽  
Visual Field Loss ◽  
Retinal Ganglion ◽  
Therapeutic Approaches ◽  
Pressure Lowering ◽  
Underlying Pathophysiology

Glaucoma is the second leading cause of blindness worldwide, affecting ~80 million people by 2020 (1, 2). The condition is characterized by a progressive loss of retinal ganglion cells (RGCs) and their axons accompanied by visual field loss. The underlying pathophysiology of glaucoma remains elusive. Glaucoma is recognized as a multifactorial disease, and lowering intraocular pressure (IOP) is the only treatment that has been shown to slow the progression of the condition. However, a significant number of glaucoma patients continue to go blind despite intraocular pressure-lowering treatment (2). Thus, the need for alternative treatment strategies is indisputable. Accumulating evidence suggests that glial cells play a significant role in supporting RGC function and that glial dysfunction may contribute to optic nerve disease. Here, we review recent advances in understanding the role of glial cells in the pathophysiology of glaucoma. A particular focus is on the dynamic and essential interactions between glial cells and RGCs and potential therapeutic approaches to glaucoma by targeting glial cells.

Intraocular Pressure–Lowering Activity of NCX 470, a Novel Nitric Oxide–Donating Bimatoprost in Preclinical Models

2015 ◽  
Vol 56 (11) ◽  
pp. 6558 ◽  
Author(s):  
Francesco Impagnatiello ◽  
Carol B. Toris ◽  
Minerva Batugo ◽  
Ganesh Prasanna ◽  
Valentina Borghi ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Intraocular Pressure ◽  
Preclinical Models ◽  
Pressure Lowering ◽  
Lowering Activity

Comparison of Nitric Oxide Donors in Lowering Intraocular Pressure in Rabbits: Role of Cyclic GMP

2002 ◽  
Vol 18 (1) ◽  
pp. 11-23 ◽  
Author(s):  
Hanna Kotikoski ◽  
Päivi Alajuuma ◽  
Eeva Moilanen ◽  
Pertteli Salmenperä ◽  
Olli Oksala ◽  
...  
Keyword(s):  
Nitric Oxide ◽  
Intraocular Pressure ◽  
Cyclic Gmp ◽  
Nitric Oxide Donors

Role of nitric oxide in the regulation of intraocular pressure: a possibility for glaucoma treatment

2010 ◽  
Vol 5 (6) ◽  
pp. 751-758
Author(s):  
Heikki Vapaatalo ◽  
Hanna Kotikoski ◽  
Olli Oksala
Keyword(s):  
Nitric Oxide ◽  
Intraocular Pressure ◽  
Glaucoma Treatment
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