New insight into the genetics of age-related macular degeneration in connection with lipid metabolism

2010 ◽  
Vol 5 (1) ◽  
pp. 15-18
Author(s):  
Lionel Bretillon ◽  
Niyazi Acar ◽  
Alain Bron ◽  
Catherine Creuzot-Garcher
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related ◽  
Insight Into

Different Populations of Circulating Endothelial Cells in Patients with Age-Related Macular Degeneration: A Novel Insight into Pathogenesis

2011 ◽  
Vol 52 (1) ◽  
pp. 93 ◽  
Author(s):  
Anna Machalinska ◽  
Krzysztof Safranow ◽  
Violetta Dziedziejko ◽  
Katarzyna Mozolewska-Piotrowska ◽  
Edyta Paczkowska ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Circulating Endothelial Cells ◽  
Age Related ◽  
Different Populations ◽  
Insight Into

scholarly journals Autophagy: A new insight into pathogenesis and treatment possibilities in age-related macular degeneration

2020 ◽  
Vol 74 ◽  
pp. 213-223
Author(s):  
Agnieszka Kubicka-Trząska ◽  
Izabella Karska-Basta ◽  
Katarzyna Żuber-Łaskawiec
Keyword(s):  
Macular Degeneration ◽  
Vision Loss ◽  
Developed Countries ◽  
Age Related Macular Degeneration ◽  
Therapeutic Modalities ◽  
Central Vision Loss ◽  
Age Related ◽  
Genetic And Environmental Factors ◽  
The Impact ◽  
Insight Into

Age-related macular degeneration (AMD) is a significant problem in healthcare, because it is a leading cause of central vision loss in individuals over 50 years old in well-developed countries. Pathogenesis of AMD is multifactorial and still not completely understood. Proven risk factors include the following: natural senescence of retina, oxidative stress, complement activation, chronic subretinal inflammatory reaction, genetic and environmental factors. Data on links between autophagy and AMD development are being raised. Autophagy is a cellular process involving the degradation of long-lived proteins and damaged fragments and components of cells; it is responsible for the maintenance of dynamic intracellular homeostasis and it enables cell survival under stress conditions. Disturbances of autophagy mechanisms, i.e. its activation or inhibition, may lead to the development of many various pathologies. Thus, autophagy plays a dual role, as a mechanism responsible for protecting or killing cells. The paper describes autophagy mechanisms and their role in the natural process of retinal cells senescence and presents the autophagy impairment as a crucial cause of AMD development. We also describe the impact of intravitreal anti-VEGF therapy on retinal autophagy mechanisms and potential new therapeutic modalities for AMD based on autophagy modulation.

scholarly journals Functional microRNA targetome undergoes degeneration-induced shift in the retina

2020 ◽  
Author(s):  
Joshua A. Chu-Tan ◽  
Zhi-Ping Feng ◽  
Yvette Wooff ◽  
Adrian V. Cioanca ◽  
Ulrike Schumann ◽  
...  
Keyword(s):  
Mouse Model ◽  
Neurodegenerative Diseases ◽  
Macular Degeneration ◽  
Retinal Degeneration ◽  
Significant Role ◽  
Age Related Macular Degeneration ◽  
Retinal Damage ◽  
Regulatory Activity ◽  
Age Related ◽  
Insight Into

SummaryMicroRNA (miRNA) play a significant role in the pathogenesis of complex neurodegenerative diseases, including age-related macular degeneration, acting as post-transcriptional gene suppressors through their association with argonaute (AGO) protein family members. However, to understand their role in disease, investigation into the regulatory nature of miRNA with their targets is required. To identify the active-miRnome-targetome interactions in the degenerating retina, AGO2 HITS-CLIP was performed using a mouse model of retinal degeneration. Analysis revealed a similar miRnome between healthy and damaged retinas, however, a shift in the active targetome was observed. This shift was also demonstrated by a change in the seed binding regions of miR-124-3p, the most abundant retinal miRNA loaded in AGO2. Following damage, AGO2 was localised to the inner retinal layers indicating a locational miRNA response to retinal damage. This study provides important insight into the alteration of miRNA regulatory activity that occurs as a response to retinal degeneration.

The Role of Lipids and Lipid Metabolism in Age-Related Macular Degeneration

2019 ◽  
pp. 47-71
Author(s):  
Christopher Fortenbach ◽  
Elissa Goldman ◽  
Amar U. Kishan ◽  
Shilpa Mathew ◽  
Bobeck S. Modjtahedi ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

Changes in lipid metabolism in women with age-related macular degeneration

2005 ◽  
Vol 4 (4) ◽  
pp. 183-187 ◽  
Author(s):  
M. Nowak ◽  
E. Swietochowska ◽  
B. Marek ◽  
B. Szapska ◽  
T. Wielkoszynski ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Age Related Macular Degeneration ◽  
Age Related

scholarly journals Renin–angiotensin system impairs macrophage lipid metabolism to promote age-related macular degeneration in mouse models

2020 ◽  
Vol 3 (1) ◽  
Author(s):  
Norihiro Nagai ◽  
Hirohiko Kawashima ◽  
Eriko Toda ◽  
Kohei Homma ◽  
Hideto Osada ◽  
...  
Keyword(s):  
Lipid Metabolism ◽  
Macular Degeneration ◽  
Pigment Epithelium ◽  
Retinal Pigment ◽  
Renin Angiotensin System ◽  
Age Related Macular Degeneration ◽  
Photoreceptor Outer Segment ◽  
Angiotensin System ◽  
Renin Angiotensin ◽  
Age Related

AbstractMetabolic syndrome, a condition involving obesity and hypertension, increases the risk of aging-associated diseases such as age-related macular degeneration (AMD). Here, we demonstrated that high-fat diet (HFD)-fed mice accumulated oxidized low-density lipoprotein (ox-LDL) in macrophages through the renin–angiotensin system (RAS). The ox-LDL-loaded macrophages were responsible for visual impairment in HFD mice along with a disorder of the retinal pigment epithelium (RPE), which is required for photoreceptor outer segment renewal. RAS repressed ELAVL1, which reduced PPARγ, impeding ABCA1 induction to levels that are sufficient to excrete overloaded cholesterol within the macrophages. The ox-LDL-loaded macrophages expressed inflammatory cytokines and attacked the RPE. An antihypertensive drug, angiotensin II type 1 receptor (AT1R) blocker, resolved the decompensation of lipid metabolism in the macrophages and reversed the RPE condition and visual function in HFD mice. AT1R signaling could be a future therapeutic target for macrophage-associated aging diseases, such as AMD.

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