Human sperm aneuploidy: FISH analysis in fertile and infertile men

2011 ◽  
Vol 6 (6) ◽  
pp. 609-627 ◽  
Author(s):  
Laura Gambera ◽  
Giuseppe Morgante ◽  
Francesca Serafini ◽  
Anita Stendardi ◽  
Raoul Orvieto ◽  
...  
Keyword(s):  
Human Sperm ◽  
Fish Analysis ◽  
Infertile Men ◽  
Sperm Aneuploidy

scholarly journals Aneuploidy in human spermatozoa: FISH analysis in men with constitutional chromosomal abnormalities, and in infertile men

Reproduction ◽  
2001 ◽  
pp. 655-666 ◽  
Author(s):  
Q Shi ◽  
RH Martin
Keyword(s):  
Chromosomal Abnormalities ◽  
Sperm Concentration ◽  
Normal Karyotype ◽  
Semen Parameters ◽  
Fish Analysis ◽  
Reciprocal Translocations ◽  
Interchromosomal Effect ◽  
Infertile Men ◽  
Sperm Aneuploidy ◽  
Increased Risk

Reproductive difficulties are associated intimately with cytogenetic abnormalities. This article reviews multicolour fluorescence in situ hybridization studies on spermatozoa from men with constitutional chromosomal abnormalities and the consequences for spermatozoa, and on chromosomal abnormalities in the spermatozoa of infertile men who have normal somatic karyotypes. In 47,XYY men, the frequencies of 24,XY and 24,YY spermatozoa appear to be < or = 1%. Klinefelter (47,XXY) and mosaic Klinefelter patients had sperm aneuploidy frequencies of 2-25% and 1.5-7.0%, respectively. Robertsonian translocation carriers had 3-27% spermatozoa unbalanced for the chromosomes involved in the translocation, with a possible modest interchromosomal effect, but none of the increased frequencies of chromosomal disomy approached 1%. The frequency of chromosomally unbalanced spermatozoa in reciprocal translocations averages 50%, is strongly dependent on the chromosomes involved in the individual translocation, and may be slightly increased as a result of a small interchromosomal effect. Infertile men with a normal karyotype and low sperm concentration or certain types of morphologically abnormal spermatozoa have a significantly increased risk of producing aneuploid spermatozoa, particularly for the sex chromosomes. An increased risk of sperm aneuploidy was not observed in infertile men with poor sperm motility or in those with a normal karyotype and normal semen parameters.

scholarly journals Increased cryo-survival rate in ejaculated human sperm from infertile men following pre-freeze in vitro myo-inositol supplementation

2018 ◽  
Vol 45 (4) ◽  
pp. 177-182 ◽  
Author(s):  
Ramadan Saleh ◽  
Hanan Assaf ◽  
Wafaa M. Abd El Maged ◽  
Mohamed Elsuity ◽  
Mohamed Fawzy
Keyword(s):  
Survival Rate ◽  
Human Sperm ◽  
Infertile Men

A comparison of sperm aneuploidy rates between infertile men with normal and abnormal karyotypes

2008 ◽  
Vol 90 ◽  
pp. S314
Author(s):  
G. Kirkpatrick ◽  
K.A. Ferguson ◽  
H. Gao ◽  
S. Tang ◽  
V. Chow ◽  
...  
Keyword(s):  
Infertile Men ◽  
Sperm Aneuploidy

scholarly journals Human sperm aneuploidy after exposure to pesticides

2004 ◽  
Vol 67 (3) ◽  
pp. 353-359 ◽  
Author(s):  
Jena L. Smith ◽  
Vincent F. Garry ◽  
Alfred W. Rademaker ◽  
Renée H. Martin
Keyword(s):  
Human Sperm ◽  
Sperm Aneuploidy

O▪42 Sperm aneuploidy screening by FISH in 310 infertile men

2005 ◽  
Vol 10 ◽  
pp. 14
Author(s):  
F Marina ◽  
R Alcolea ◽  
L Latre ◽  
C González ◽  
S Mateo ◽  
...  
Keyword(s):  
Aneuploidy Screening ◽  
Infertile Men ◽  
Sperm Aneuploidy
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