scholarly journals Phytochemistry and Biological Properties of Burnet Weed (Sanguisorba spp.): A Review

2014 ◽  
Vol 6 (4) ◽  
pp. 395-398 ◽  
Author(s):  
Anestis KARKANIS ◽  
Evangelos VELLIOS ◽  
Thomas THOMAIDIS ◽  
Dimitrios BILALIS ◽  
Aspasia EFTHIMIADOU ◽  
...  
Keyword(s):  
Crop Production ◽  
Biological Activities ◽  
Biological Properties ◽  
Bioactive Components ◽  
Anticancer Properties ◽  
Perennial Weeds ◽  
The World ◽  
Potential Applications ◽  
Antiviral Activities ◽  
Sanguisorba Officinalis

Great burnet (Sanguisorba officinalis L.) and small burnet (Sansguisorba minor Scop.) are edible, perennial weeds widely distributed in the world. These are the most widespread Sanguisorba species. The bioactive components of Sanguisorba plants include phenolics (phenolic acids, flavonoids and neolignans) and terpenoids. Large potential exists to use burnets as medicinal plants. Sanguisorba species are known to show anticancer properties, antioxidative, antimicrobial and antiviral activities. Also, Sanguisorba extracts show anti-Alzheimer and anti-inflammatory properties. Small burnet extracts could also be a useful alternative to synthetic fungicides for crop production. This review focuses on biological activities of Sanguisorba extracts and emphasizing their potential applications in pharmaceutical areas.

scholarly journals Monoterpenes and Sesquiterpenes of Essential Oils from Psidium Species and Their Biological Properties

Molecules ◽  
2021 ◽  
Vol 26 (4) ◽  
pp. 965
Author(s):  
Renan Campos e Silva ◽  
Jamile S. da Costa ◽  
Raphael O. de Figueiredo ◽  
William N. Setzer ◽  
Joyce Kelly R. da Silva ◽  
...  
Keyword(s):  
Essential Oils ◽  
Biological Activities ◽  
Biological Properties ◽  
Chemical Diversity ◽  
New Drugs ◽  
Natural Sources ◽  
Biological Potential ◽  
The World ◽  
Review Reports ◽  
Collection Sites

Psidium (Myrtaceae) comprises approximately 266 species, distributed in tropical and subtropical regions of the world. Psidium taxa have great ecological, economic, and medicinal relevance due to their essential oils’ chemical diversity and biological potential. This review reports 18 Psidium species growing around the world and the chemical and biological properties of their essential oils. Chemically, 110 oil records are reported with significant variability of volatile constituents, according to their seasonality and collection sites. Monoterpenes and sesquiterpenes with acyclic (C10 and C15), p-menthane, pinane, bisabolane, germacrane, caryophyllane, cadinane, and aromadendrane skeleton-types, were the primary constituents. The essential oils showed various biological activities, including antioxidant, antifungal, antibacterial, phytotoxic, larvicidal, anti-inflammatory, and cytotoxic properties. This review contributes to the Psidium species rational and economic exploration as natural sources to produce new drugs.

scholarly journals Alkaloids Produced by Endophytic Fungi: A Review

2012 ◽  
Vol 7 (7) ◽  
pp. 1934578X1200700 ◽  
Author(s):  
Yanyan Zhang ◽  
Ting Han ◽  
Qianliang Ming ◽  
Lingshang Wu ◽  
Khalid Rahman ◽  
...  
Keyword(s):  
Endophytic Fungi ◽  
Host Plants ◽  
Biological Activities ◽  
Biological Properties ◽  
Research Progress ◽  
Indole Derivatives ◽  
Anticancer Activities ◽  
Action Mechanisms ◽  
The Future ◽  
Potential Applications

In recent years, a number of alkaloids have been discovered from endophytic fungi in plants, which exhibited excellent biological properties such as antimicrobial, insecticidal, cytotoxic, and anticancer activities. This review mainly deals with the research progress on endophytic fungi for producing bioactive alkaloids such as quinoline and isoquinoline, amines and amides, indole derivatives, pyridines, and quinazolines. The biological activities and action mechanisms of these alkaloids from endophytic fungi are also introduced. Furthermore, the relationships between alkaloid-producing endophytes and their host plants, as well as their potential applications in the future are discussed.

scholarly journals Type I Interferons: Distinct Biological Activities and Current Applications for Viral Infection

2018 ◽  
Vol 51 (5) ◽  
pp. 2377-2396 ◽  
Author(s):  
Shi-fang Li ◽  
Mei-jiao Gong ◽  
Fu-rong Zhao ◽  
Jun-jun Shao ◽  
Yin-li Xie ◽  
...  
Keyword(s):  
Biological Activities ◽  
Therapeutic Option ◽  
Influenza Viruses ◽  
Type I Interferons ◽  
Type I ◽  
Virus Infections ◽  
Type I Ifns ◽  
Immunodeficiency Virus ◽  
Potential Applications ◽  
Antiviral Activities

The interferons (IFNs) are a primary defense against pathogens because of the strong antiviral activities they induce. IFNs can be classified into three groups: type I, type II and type III, according to their genetic, structural, and functional characteristics and their receptors on the cell surface. The type I IFNs are the largest group and include IFN-α, IFN-β, IFN-ε, IFN-ω, IFN-κ, IFN-δ, IFN-τ and IFN-ζ. The use of IFNs for the treatment of viral infectious diseases on their antiviral activity may become an important therapeutic option, for example, IFN-α is well known for the successful treatment of hepatitis B and C virus infections, and interest is increasing in the antiviral efficacy of other novel IFN classes and their potential applications. Therefore, in this review, we summarize the recent progress in the study of the biological activities of all the type I IFN classes and their potential applications in the treatment of infections with immunodeficiency virus, hepatitis viruses, and influenza viruses.

scholarly journals In vitro and in vivo biological activities of azulene derivatives with potential applications in medicine

2021 ◽  
Author(s):  
Paweł Bakun ◽  
Beata Czarczynska-Goslinska ◽  
Tomasz Goslinski ◽  
Sebastian Lijewski
Keyword(s):  
Biological Activities ◽  
Biological Properties ◽  
Biologically Active ◽  
Peptic Ulcers ◽  
Artemisia Absinthium ◽  
Potential Applications ◽  
Anti Inflammatory ◽  
Unique Chemical

AbstractAzulene is an aromatic hydrocarbon that possesses a unique chemical structure and interesting biological properties. Azulene derivatives, including guaiazulene or chamazulene, occur in nature as components of many plants and mushrooms, such as Matricaria chamomilla, Artemisia absinthium, Achillea millefolium, and Lactarius indigo. Due to physicochemical properties, azulene and its derivatives have found many potential applications in technology, especially in optoelectronic devices. In medicine, the ingredients of these plants have been widely used for hundreds of years in antiallergic, antibacterial, and anti-inflammatory therapies. Herein, the applications of azulene, its derivatives and their conjugates with biologically active compounds are presented. The potential use of these compounds concerns various areas of medicine, including anti-inflammatory with peptic ulcers, antineoplastic with leukemia, antidiabetes, antiretroviral with HIV-1, antimicrobial, including antimicrobial photodynamic therapy, and antifungal.

scholarly journals Phytochemical Profile and Biological Activities of Satureja hortensis L.: A Review of the Last Decade

Molecules ◽  
2018 ◽  
Vol 23 (10) ◽  
pp. 2458 ◽  
Author(s):  
Irina Fierascu ◽  
Cristina Elena Dinu-Pirvu ◽  
Radu Claudiu Fierascu ◽  
Bruno Stefan Velescu ◽  
Valentina Anuta ◽  
...  
Keyword(s):  
Biological Activities ◽  
Scientific Data ◽  
Future Research ◽  
Satureja Hortensis ◽  
Anticancer Properties ◽  
Potential Applications ◽  
Ancient Times ◽  
Review Study ◽  
Phytochemical Profile ◽  
Made In

Satureja hortensis L. (summer savory) is an annual herbaceous crop, native to Europe and in our days spread and used all over the world. Although its use as spice and medicinal plant is known since ancient times, peer-reviewed studies presenting the scientific data are scarce. The natural products obtained from summer savory (extracts and essential oil) are dominated by polyphenols and flavonoids, responsible for their antioxidant, antimicrobial, antiparasitic, pesticidal, anti-inflammatory, analgesic, hepatoprotective and anticancer properties, among others. The current study presents the progress made in the last decade regarding the potential applications of summer savory, being the first review study focused on S. hortensis, in the same time suggesting future research opportunities, as they appear from the properties of other Satureja species. The available data presenting the properties of summer savory represents a scientific support for application in industry, for developing “clean label” food products.

Structure, biosynthesis, and biological activities of cyclooligomer depsipeptides from fungi

2021 ◽  
Vol 66 (1) ◽  
pp. 124-133
Author(s):  
Van Nguyen Thi Thuy ◽  
Viet Nguyen Dinh ◽  
Lam Duong Minh
Keyword(s):  
Hydroxy Acid ◽  
Biological Activities ◽  
Ring Structure ◽  
Nonribosomal Peptide ◽  
Nonribosomal Peptide Synthetases ◽  
Peptide Synthetases ◽  
Natural Substances ◽  
Symmetric Structure ◽  
Potential Applications ◽  
Antiviral Activities

Cyclooligomer depsipeptides (CODs) are peptolides, in which their symmetric structure ring structure has two or more ester bonds formed and alternately arranged between amino and α-hydroxy acid. CODs belong to four main groups of cyclotetrapeptides, cyclohexadepsipeptides, cyclooctadepsipeptides and diketomorpholines. These compounds have been mainly isolated from Acremonium, Aspergillus, Beauveria, Cordyceps, Fusarium, Isaria, Nigrospora, Peacilomyces, and Verticillium. The biosynthesis of CODs takes place outside the ribosome by giant multi-domain enzymes called nonribosomal peptide synthetases (NRPSs). Two different models about the formation of these depsipeptides were proposed. Fungal CODs are known to exhibit various biological activities, especially insecticidal, antitumoral, antimicrobial and antiviral activities. Therefore, CODs are considered to be natural substances with extremely potential applications in medicine and agriculture. This review highlights the structures, classification, biosynthesis, and biological activities of the fungal CODs.

scholarly journals Antiviral Activities of Curcuma Genus against Hepatitis C Virus

2018 ◽  
Vol 13 (12) ◽  
pp. 1934578X1801301 ◽  
Author(s):  
Tutik Sri Wahyuni ◽  
Adita Ayu permatasari ◽  
Tri Widiandani ◽  
Achmad Fuad ◽  
Aty Widyawaruyanti ◽  
...  
Keyword(s):  
Life Cycle ◽  
Hepatitis C Virus ◽  
Hepatitis C ◽  
Mode Of Action ◽  
Biological Activities ◽  
Hcv Infection ◽  
The World ◽  
Action Analysis ◽  
Antiviral Activities ◽  
Post Entry

Hepatitis C virus (HCV) infection is one of the major public health problems in the world. Even though the new agents are shown to increase the sustained virology response, however, there are still many people who cannot access the therapy due to the high cost. Moreover, the emergence of resistance and side effects presented the necessity to develop alternative treatment agents for HCV infection. Plants of the genus of curcuma are popular among traditional medicines in the world, including Indonesia. They have been used for many herb remedies and reported to possess many biological activities. Several plants from the curcuma genus were known as treatment agents in liver disease and jaundice. Our current study determines antiviral activities of Curcuma domestica, Curcuma xanthorrhiza, and Curcuma heyneana against HCV and further examines the mechanism of actions. Antiviral activity was performed by in vitro culture cells using Huh 7.5it cells and treated with the mixture of extract and virus JFH1. The effects of extracts in HCV life cycle were determined by mode of action analysis to examine the action of substances in the entry or post entry steps. The results revealed that ethanol extract of C. domestica, C. xanthorrhiza, and C. heyneana showed strong anti-HCV activities with IC50 values of 1.68 ± 0.05, 4.93 ± 0.42 and 5.49 ± 0.59 μg/mL, respectively without any cytotoxicity effect. Mode of action analysis demonstrated that of C. domestica and C. heyneana exhibit HCV in the entry step, while C. xanthorrhiza inhibit in the entry and post entry steps of HCV life cycle. Docking analysis to predict the interaction of curcumin, the main compound of curcuma genus, revealed a strong interaction between curcumin and 4GAG receptor, a protein involved in the entry step of HCV infection. Moreover, it was also reported to possess good interaction with 4EAW, an HCV NS5B, which plays an important role in HCV replication. These results suggested that C. domestica, C. xanthorrhiza, and C. Heyneana possessed strong inhibition against hepatitis C virus, therefore they may be good candidates for anti-HCV agents.

scholarly journals Lamiaceae Essential Oils, Phytochemical Profile, Antioxidant, and Biological Activities

2021 ◽  
Vol 2021 ◽  
pp. 1-18
Author(s):  
Luiz Renan Ramos da Silva ◽  
Oberdan Oliveira Ferreira ◽  
Jorddy Nevez Cruz ◽  
Celeste de Jesus Pereira Franco ◽  
Tainá Oliveira dos Anjos ◽  
...  
Keyword(s):  
Literature Review ◽  
Essential Oils ◽  
Biological Activities ◽  
Antimicrobial Activities ◽  
Biological Properties ◽  
Aromatic Plants ◽  
Medicinal And Aromatic Plants ◽  
Physical Chemical ◽  
Potential Applications ◽  
Phytochemical Profile

Medicinal and aromatic plants present important active compounds that have potential for use in food, pharmaceutical, and agriculture industries. In this sense, the present work aimed to conduct a literature review on the potential applications of essential oils from Lamiaceae species. Antioxidant, anti-inflammatory, and antimicrobial activities were evaluated. The importance of this study is demonstrated as a way to theoretically provide information on the use of different plants belonging to the Lamiaceae family, especially with regard to the physical, chemical, and biological properties of its essential oils.

Diverse chemical and biological potentials of various pyridazine and pyridazinone derivatives

2019 ◽  
Author(s):  
Chem Int
Keyword(s):  
Heterocyclic Compounds ◽  
Biological Activities ◽  
Wide Spectrum ◽  
Biological Properties ◽  
Industrial Chemical ◽  
Anti Inflammatory ◽  
Pyridazinone Derivatives

A series of heterocyclic compounds incorporating pyridazine moiety were for diverse biological activities. Pyridazines and pyridazinones derivatives showed wide spectrum of biological activities such as vasodialator, cardiotonic, anticonvulsant, antihypertensive, antimicrobial, anti-inflammatory, analgesic, anti-feedant, herbicidal, and various other biological, agrochemical and industrial chemical activities. The results illustrated that the synthesized pyridazine/pyridazine compounds have diverse and significant biological activities. Mechanistic insights into the biological properties of pyridazinone derivatives and various synthetic techniques used for their synthesis are also described.

Determination of Antioxidant Activities and Bioactive Components of Foeniculum vulgare Mill. (Samonsabar)

2019 ◽  
Vol 30 (3) ◽  
pp. 16-22
Keyword(s):  
Antioxidant Activities ◽  
Biological Activities ◽  
Scientific Information ◽  
Ethanolic Extract ◽  
The Body ◽  
World Health ◽  
Gas Chromatography Mass Spectrometry ◽  
Molecular Formula ◽  
Bioactive Components ◽  
Foeniculum Vulgare

World Health Organization (WHO) estimated that 80% of the population of developing countries use traditional medicines, mostly natural plant products, for their primary health care needs. In the past few decades, the medicinal value of plants has been assumed more important dimension owing largely to the discovery that extracts from plants contain not only primary metabolites but also a diverse array of secondary metabolites with antioxidant potential. Medicinal plants are potential sources of natural compounds with biological activities and therefore attract the attention of researchers worldwide. Antioxidants are vital substances which possess ability to protect the body from damage due to free radical-induced oxidative stress. The purpose of current study was to determine the antioxidant activities and bioactive components of Foeniculum vulgare (fennel) (Samonsabar) seeds by using UV Visible Spectrophotometer (UV-Vis) and Gas Chromatography-Mass Spectrometry (GC-MS). Aqueous extract of fennel seeds showed more antioxidant activity (IC50: 0.28 ug/ml) than ethanolic extract (IC50: 0.83 ug/ml) and comparable to standard antioxidant, ascorbic acid (IC50: 0.59 ug/ml). GC-MS analysis was fruitful in identification of compounds based on peak area, retention time, molecular formula, molecular weight, MS Fragmentions and pharmacological actions. Ten bioactive phytochemical compounds from aqueous extracts and 11 from ethanolic extract of fennel seeds were identified. These findings indicated that fennel seeds are potential to provide preventive properties against oxidative damage. These results will give scientific information for quality control of indigenous drug to herbal medicine users and local practitioners using fennel for different types of ailments

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