scholarly journals Can preoperative serum thyroglobulin and anti-thyroglobulin levels predict malignant potential of a thyroid nodule with atypia or follicular lesion of undetermined significance?

2020 ◽  
Vol 5 (2) ◽  
Author(s):  
Amal Alhefdhi ◽  
Tahani Altayyar ◽  
Saad M Alqahtani ◽  
Mohammed Alshehri ◽  
Salahudin Elnaas ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Malignant Potential ◽  
Serum Thyroglobulin ◽  
Preoperative Serum ◽  
Undetermined Significance

The role of preoperative serum thyroglobulin values in the diagnosis of differentiated thyroid cancer

2017 ◽  
Author(s):  
Blertina Dyrmishi ◽  
Taulant Olldashi ◽  
Ema Lumi ◽  
Entela Puca ◽  
Dorina Ylli ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Differentiated Thyroid Cancer ◽  
Serum Thyroglobulin ◽  
Preoperative Serum

Is there a role of measuring preoperative serum thyroglobulin?

2021 ◽  
Author(s):  
Elvas Ana Rita ◽  
Bernardo Marques ◽  
Joana Couto ◽  
G. Martins Raquel ◽  
Jacinta Santos ◽  
...  
Keyword(s):  
Serum Thyroglobulin ◽  
Preoperative Serum

scholarly journals Ig VH gene mutational patterns indicate different tumor cell status in human myeloma and monoclonal gammopathy of undetermined significance

Blood ◽  
1996 ◽  
Vol 87 (2) ◽  
pp. 746-755 ◽  
Author(s):  
SS Sahota ◽  
R Leo ◽  
TJ Hamblin ◽  
FK Stevenson
Keyword(s):  
Multiple Myeloma ◽  
Tumor Cell ◽  
Plasma Cell ◽  
Monoclonal Gammopathy ◽  
Somatic Hypermutation ◽  
Wide Spectrum ◽  
Malignant Potential ◽  
Gene Sequences ◽  
Vh Gene ◽  
Undetermined Significance

Plasma cell tumors display a wide spectrum of clinical progression, ranging from aggressive multiple myeloma to a benign form known as monoclonal gammopathy of undetermined significance (MGUS), which requires no treatment. Because both diseases involve mature Ig- secreting plasma cells, the reason for this variation in malignant behavior is unclear. However, assessment of malignant potential is desirable for choice of treatment protocols. Ig variable (VH) gene sequences analysis has previously shown the tumor cell of multiple myeloma to be postfollicular, with mutated homogeneous clonal sequences indicating no continuing exposure to the somatic hypermutation mechanism, and this was confirmed in 7 of 7 patients. Comparison of the VH gene sequences in the monoclonal cells in MGUS yielded a different result, with 3 of 7 patients demonstrating mutated heterogeneous sequences consistent with the tumor cells remaining under the influence of the mutator. In 1 of 3 of these patients, an IgM-positive precursor cell was identified that expressed heterogeneous VH sequences similar to those of the isotype-switched plasma cell. These results indicate that the clonal cells in MGUS differ from those in myeloma and suggest that the difference may reflect malignant potential.

scholarly journals Preoperative Serum Thyroglobulin and Its Correlation with the Burden and Extent of Differentiated Thyroid Cancer

Cancers ◽  
2020 ◽  
Vol 12 (3) ◽  
pp. 625
Author(s):  
Hosu Kim ◽  
So Young Park ◽  
Jun-Ho Choe ◽  
Jee Soo Kim ◽  
Soo Yeon Hahn ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Primary Tumor ◽  
Differentiated Thyroid Cancer ◽  
Medical Center ◽  
Distant Metastases ◽  
Predictive Biomarker ◽  
Tumor Burden ◽  
Serum Thyroglobulin ◽  
Preoperative Serum ◽  
Clinical Records

Lymph node metastasis (LNM) in differentiated thyroid cancer (DTC) is usually detected with preoperative ultrasonography; however, this has limited sensitivity for small metastases, and there is currently no predictive biomarker that can help to inform the extent of surgery required. We evaluated whether preoperative serum thyroglobulin levels can predict tumor burden and extent. We retrospectively reviewed the clinical records of 4029 DTC cases diagnosed and treated at a Samsung Medical Center between 1994 and 2016. We reviewed primary tumor size, number and location of LNM, and presence of distant metastases to reveal relationships between tumor burden and extent and preoperative serum thyroglobulin levels. We found a linear association between increasing preoperative thyroglobulin levels, the size of the primary tumor, and the number of LNM (r = 0.34, p < 0.001, r = 0.20, p < 0.001, respectively). Tumor extent also increased with each decile of increasing preoperative thyroglobulin level (r = 0.18, p < 0.001). Preoperative thyroglobulin levels of 13.15 ng/mL, 30.05 ng/mL, and 62.9 ng/mL were associated with the presence of ipsilateral lateral LNM, contralateral lateral LNM, and distant metastasis, respectively. Our results suggest that preoperative measurement of serum thyroglobulin may help to predict LNM and help to tailor surgery.

Serum Thyroglobulin Improves the Sensitivity of the McGill Thyroid Nodule Score for Well-Differentiated Thyroid Cancer

Thyroid ◽  
2014 ◽  
Vol 24 (5) ◽  
pp. 852-857 ◽  
Author(s):  
Patrick Scheffler ◽  
Veronique I. Forest ◽  
Rebecca Leboeuf ◽  
Anca V. Florea ◽  
Michael Tamilia ◽  
...  
Keyword(s):  
Thyroid Cancer ◽  
Thyroid Nodule ◽  
Differentiated Thyroid Cancer ◽  
Serum Thyroglobulin ◽  
Well Differentiated

scholarly journals Correlation of Ultrasonography Guided Fine Needle Aspiration Cytology with Postoperative Histopathology in Diagnosis of Thyroid Nodule

2021 ◽  
Vol 27 (1) ◽  
pp. 36-43
Author(s):  
Md Jaber Al Sayied ◽  
A Allam Choudhury ◽  
Sonia Jahan Bithi ◽  
Ashim Kumar Biswas ◽  
Riashat Azim Majumder ◽  
...  
Keyword(s):  
Thyroid Nodule ◽  
Fine Needle Aspiration ◽  
Predictive Value ◽  
Needle Aspiration ◽  
Follicular Neoplasm ◽  
Ultrasound Guided ◽  
Aspiration Cytology ◽  
Fine Needle ◽  
Needle Aspiration Cytology ◽  
Undetermined Significance

Background: Fine-needle aspiration cytology (FNAC) is recommended as a decisive diagnostic step in the workup of patients with nodular thyroid disease. Unfortunately, FNAC can miss malignancies in smaller and deeper nodule. Ultrasound guided FNAC (US-FNAC) can reduce this error in suspicious thyroid nodule. Objectives: To find out the correlation of USG guided FNAC with postoperative histopathology in diagnosis of thyroid nodule. Methods: After obtaining clearance and approval from Institutional Review Board, all 45 patients of thyroid nodule who were admitted in the Department of Otolaryngology – Head & Neck surgery of Bangabandhu Sheikh Mujib Medical University (BSMMU), Dhaka from April 2017 to August 2018 and had fulfilled the inclusion and exclusion criteria were selected for the study. Each patient was assessed before surgery by USG guided FNAC and post operatively by histopathology. Results: In this study mean age of the respondents was 33.33 yearswith SD±10.84. Male female ration was 1:5.4. USG guided FNAC was reported by ‘The Bethesda System for Reporting Thyroid Cytopathology’ (TBS-RTC).Of the 45 specimens 2 samples were nondiagnostic or unsatisfactory (Class I), 26 samples were benign (Class II), 2 samples were showing Atypia of Undetermined Significance or Follicular lesion of Undetermined Significance (Class III), 6 were showing follicular neoplasm or suspicious for a follicular neoplasm (Class IV), 5 samples were suspicious for malignancy (Class V) and 4 samples were positive for malignancy (Class VI). On comparison of ultrasound guided FNAC with histopathology the sensitivity for correct diagnosis was 94%, specificity was 93%, positive predictive value was 88%, negative predictive value was 96% and accuracy was 93%. Pearson’s correlation coefficient was 0.85 which is very strong for positive relationship. Conclusion: USG guided FNAC is the most accurate method for diagnostic evaluation of thyroid nodules. Bangladesh J Otorhinolaryngol; April 2021; 27(1): 36-43

scholarly journals Application of the Milan System for Reporting Salivary Gland Cytopathology: A Retrospective 12-Year Bi-institutional Study

2019 ◽  
Vol 151 (6) ◽  
pp. 613-621 ◽  
Author(s):  
Howard H Wu ◽  
Fatimah Alruwaii ◽  
Bao-Rung Zeng ◽  
Harvey M Cramer ◽  
Chiung-Ru Lai ◽  
...  
Keyword(s):  
Salivary Gland ◽  
Benign Neoplasm ◽  
Malignant Potential ◽  
Salivary Gland Neoplasm ◽  
Uncertain Malignant Potential ◽  
Risk Of Malignancy ◽  
Predictive Rate ◽  
Sensitivity Specificity ◽  
Undetermined Significance

Abstract Objectives Multi-institutional studies are required for the validation of the Milan System for Reporting Salivary Gland Cytopathology (MSRSGC). Methods A total of 1,560 fine-needle aspirations of the salivary glands were retrieved from two institutions for a 12-year period. The diagnoses were reclassified based on the MSRSGC. Risk of malignancy (ROM) for each category was calculated based on 694 histologic follow-up cases. Results The ROM for each category was: 18.3% for nondiagnostic, 8.9% for nonneoplastic, 37.5% for atypia of undetermined significance (AUS), 2.9% for benign neoplasm, 40.7% for salivary gland neoplasm of uncertain malignant potential (SUMP), 100% for suspicious for malignancy, and 98.3% for malignant. The sensitivity, specificity, positive predictive rate, and negative predictive rates were 89%, 99%, 98%, and 96%, respectively. Conclusions The results of the current study are in keeping with the MSRSGC. The indeterminate categories of AUS and SUMP showed intermediate ROMs at 37.5% and 40.7%, respectively.

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