How to remove nose skin excess?. Aesthetically reasonable approach

I do not have access to the abstracts of the first meeting of EMSA but at this, the 50th Anniversary meeting of the Electron Microscopy Society of America, I have an excuse to consider the historical origins of the approaches we take to the use of electron microscopy for the characterisation of materials. I have myself been actively involved in the use of TEM for the characterisation of heterogeneities for little more than half of that period. My own view is that it was between the 3rd International Meeting at London, and the 1956 Stockholm meeting, the first of the European series , that the foundations of the approaches we now take to the characterisation of a material using the TEM were laid down. (This was 10 years before I took dynamical theory to be etched in stone.) It was at the 1956 meeting that Menter showed lattice resolution images of sodium faujasite and Hirsch, Home and Whelan showed images of dislocations in the XlVth session on “metallography and other industrial applications”. I have always incidentally been delighted by the way the latter authors misinterpreted astonishingly clear thickness fringes in a beaten (”) foil of Al as being contrast due to “large strains”, an error which they corrected with admirable rapidity as the theory developed. At the London meeting the research described covered a broad range of approaches, including many that are only now being rediscovered as worth further effort: however such is the power of “the image” to persuade that the above two papers set trends which influence, perhaps too strongly, the approaches we take now. Menter was clear that the way the planes in his image tended to be curved was associated with the imaging conditions rather than with lattice strains, and yet it now seems to be common practice to assume that the dots in an “atomic resolution image” can faithfully represent the variations in atomic spacing at a localised defect. Even when the more reasonable approach is taken of matching the image details with a computed simulation for an assumed model, the non-uniqueness of the interpreted fit seems to be rather rarely appreciated. Hirsch et al., on the other hand, made a point of using their images to get numerical data on characteristics of the specimen they examined, such as its dislocation density, which would not be expected to be influenced by uncertainties in the contrast. Nonetheless the trends were set with microscope manufacturers producing higher and higher resolution microscopes, while the blind faith of the users in the image produced as being a near directly interpretable representation of reality seems to have increased rather than been generally questioned. But if we want to test structural models we need numbers and it is the analogue to digital conversion of the information in the image which is required.

Download Full-text

Handbook for Scientometrics: Science and Technology Development Indicators

10.15826/b978-5-7996-3154-3 ◽

2020 ◽

Author(s):

Mark Akoev ◽

◽

Valentina Markusova ◽

Olga Moskaleva ◽

Vladimir Pislyakov ◽

...

Keyword(s):

Technology Development ◽

Citation Index ◽

Research Evaluation ◽

Research Management ◽

Research Assessment ◽

Research Institutions ◽

Scientometric Indicators ◽

Development Indicators ◽

Reasonable Approach ◽

Eugene Garfield

The Second edition Russian Scientometric Handbook is designed to provide an overview of the field of scientometrics. The Handbook describes the history of creation of the breakthrough concept of citation indexing by Dr. Eugene Garfield, and development of the first multidisciplinary scholarly citation index, the Science Citation Index. Application of scientometric tools and methods in research management and resource allocation is discussed. Authors survey various scientometric indicators relevant to individual researchers, journals, research institutions and whole countries. Authors explore new types of indicators, such as altmetrics, relationship between scientometric indicators and the nature of scientific communication, and various methods of visualizing scientometric information. Possibilities and limitations of various scientometric techniques are examined. Authors highlight the need for an informed and reasonable approach to the use of quantitative indicators for research assessment. The Handbook includes the first Russian translations of three articles by Dr. Eugene Garfield. The Handbook is intended for use by researchers, science analysts, universities and research institutions administrators, libraries and information centers staff, graduate students, and the general reader interested in scientometrics and research evaluation.

Download Full-text

Hepatitis A Seroprevalence Among Patients with Chronic Hepatitis B Infection: A Cross-Sectional Study in Iran During 2016-2017

Infectious Disorders - Drug Targets ◽

10.2174/1871526519666191009144848 ◽

2020 ◽

Vol 20 (5) ◽

pp. 748-751

Author(s):

Seyed Ali Dehghan Manshadi ◽

Neda Alijani ◽

Mohammadreza Salehi ◽

Omid Dadras ◽

SeyedAhmad SeyedAlinaghi ◽

...

Keyword(s):

Chronic Hepatitis ◽

Hepatitis B ◽

Chronic Hepatitis B ◽

Hepatitis A ◽

Cross Sectional Study ◽

University Hospital ◽

Cross Sectional ◽

Reasonable Approach ◽

The Difference ◽

Prevention Method

Introduction: The aim of this study was to determine the prevalence of exposure to hepatitis A by means of serologic markers in chronic hepatitis B patients, with the secondary aim of finding the best prevention method for hepatitis A infection in susceptible groups of our setting. Methods: During the period between 2016 and 2017, we recruited 403 hepatitis B patients aged more than 14 years and regularly attending the infectious diseases clinic at a referral university hospital, Tehran, Iran. A blood sample was collected from all the patients and tested for hepatitis A IgG. The data was analyzed by SPSS v.19. Results: Although none of the patients had previously received hepatitis A vaccine, the results for serologic level of hepatitis A IgG, demonstrated positive results in 379 (94%) cases. The mean age of patients with negative and positive IgG was 29.17 and 42.46 years, respectively; the difference was statistically significant (P≤0.001). The majority of seronegative patients were young adults aged < 25 years and 25 to 35 years (P <0.001). Conclusion: Seroprevalence of hepatitis A in chronic HBV patients in Iran is high. As HBV infected patients younger than 35 years could be seronagative for HAV infection, evaluation of these patients for HAV infection and vaccination of seronegative patients would be a reasonable approach.

Download Full-text

New Potential Biomarkers for Chronic Kidney Disease Management—A Review of the Literature

International Journal of Molecular Sciences ◽

10.3390/ijms22010043 ◽

2020 ◽

Vol 22 (1) ◽

pp. 43

Author(s):

Irina Lousa ◽

Flávio Reis ◽

Idalina Beirão ◽

Rui Alves ◽

Luís Belo ◽

...

Keyword(s):

Chronic Kidney Disease ◽

Clinical Practice ◽

Kidney Disease ◽

Renal Damage ◽

Recent Literature ◽

Therapeutic Interventions ◽

Review Of The Literature ◽

Medical Need ◽

Early Use ◽

Reasonable Approach

The prevalence of chronic kidney disease (CKD) is increasing worldwide, and the mortality rate continues to be unacceptably high. The biomarkers currently used in clinical practice are considered relevant when there is already significant renal impairment compromising the early use of potentially successful therapeutic interventions. More sensitive and specific biomarkers to detect CKD earlier on and improve patients’ prognoses are an important unmet medical need. The aim of this review is to summarize the recent literature on new promising early CKD biomarkers of renal function, tubular lesions, endothelial dysfunction and inflammation, and on the auspicious findings from metabolomic studies in this field. Most of the studied biomarkers require further validation in large studies and in a broad range of populations in order to be implemented into routine CKD management. A panel of biomarkers, including earlier biomarkers of renal damage, seems to be a reasonable approach to be applied in clinical practice to allow earlier diagnosis and better disease characterization based on the underlying etiologic process.

Download Full-text

Hybrid intelligence in hospitals: towards a research agenda for collaboration

Electronic Markets ◽

10.1007/s12525-021-00457-4 ◽

2021 ◽

Author(s):

Milad Mirbabaie ◽

Stefan Stieglitz ◽

Nicholas R. J. Frick

Keyword(s):

Hospital Setting ◽

Care Process ◽

Future Research ◽

Conversational Agents ◽

Actual Application ◽

Reasonable Approach ◽

Hybrid Intelligence ◽

Application Of Cas ◽

Successful Collaboration

AbstractSuccessful collaboration between clinicians is particularly relevant regarding the quality of care process. In this context, the utilization of hybrid intelligence, such as conversational agents (CAs), is a reasonable approach for the coordination of diverse tasks. While there is a great deal of literature involving collaboration, little effort has been made to integrate previous findings and evaluate research when applying CAs in hospitals. By conducting an extended and systematic literature review and semi-structured expert interviews, we identified four major challenges and derived propositions where in-depth research is needed: 1) audience and interdependency; 2) connectivity and embodiment; 3) trust and transparency; and 4) security, privacy, and ethics. The results are helpful for researchers as we discuss directions for future research on CAs for collaboration in a hospital setting enhancing team performance. Practitioners will be able to understand which difficulties must be considered before the actual application of CAs.

Download Full-text

Development and Validation of New Reverberation Chamber for Wireless Devices

Wireless Communications and Mobile Computing ◽

10.1155/2018/7068601 ◽

2018 ◽

Vol 2018 ◽

pp. 1-12 ◽

Cited By ~ 2

Author(s):

Dong-Uk Sim ◽

Sang Il Kwak ◽

Jong Hwa Kwon ◽

Seong-Ook Park

Keyword(s):

Standard Deviation ◽

Electromagnetic Compatibility ◽

Initial Structure ◽

Wireless Devices ◽

Reverberation Chamber ◽

Working Volume ◽

Wireless Terminal ◽

Reasonable Approach ◽

Measurement And Evaluation ◽

Development And Validation

This paper proposes a reverberation chamber structure consisting of new reflectors and mode stirrers for electromagnetic compatibility and wireless terminal measurements. The key design considerations for them are determined through a reasonable approach to analyze the eigenmode for a reverberation chamber and the standard deviation of its working volume based on 3D simulation. The final designs are expected to improve the standard deviation performance of the initial structure of the reverberation chamber and provide a better mode stirring environment. The results measured in the fabricated chamber demonstrate that these predictions are clearly realized. The results satisfy the main requirements of this paper, which are defined in consideration of the specifications of commercial reverberation chamber products. Therefore, the reverberation chamber of this paper is expected to be useful for performance measurement and evaluation of commercial wireless terminals. To verify this logical approach to obtain a good design and its results, the results measured in the actual fabricated reverberation chamber are described along with analytical and computational results.

Download Full-text

Abstract 147: Hypertension-related Admission and Mortality at a Referral Hospital in Tanzania - A Call to Action

Hypertension ◽

10.1161/hyp.60.suppl_1.a147 ◽

2012 ◽

Vol 60 (suppl_1) ◽

Author(s):

Naomi Shike ◽

Santosh Vardhana ◽

Judith Briant ◽

Robert Peck

Keyword(s):

Heart Failure ◽

Medical Center ◽

Tertiary Care ◽

Sub Saharan Africa ◽

Morbidity And Mortality ◽

Hospital Death ◽

Care Hospital ◽

Common Cause ◽

Related Disease ◽

Reasonable Approach

Introduction The WHO has been increasingly emphasizing and calling for research on the vast unattended burden of non-communicable diseases in the developing world. Hypertension (HTN) in particular is thought to play a growing role in morbidity and mortality in these regions, but has yet to gain significant momentum in public health initiatives. Objective To determine what role HTN and comorbid diseases play in admission and mortality in Bugando Medical Center (BMC), a tertiary care hospital in Tanzania serving 13 million people. Methods We conducted a retrospective analysis of all patients admitted to the internal medicine service at BMC over 34 months between 2008 and 2011. Data on admission diagnoses and mortality had been collected prospectively by Tanzanian doctors in hand-written logs. For patients with heart failure or stroke, the ward logs specified if this was primarily related to hypertension or other risk factors. Data were copied into an Excel database and analyzed to determine the proportion of admissions and deaths primarily related to hypertension. Results In 34 months 8,037 patients were admitted and 1,508 died. HTN-related disease led to 1,997 admissions (25%), while HIV-related illness led to 2,076 (26%). Similarly, HTN led to 377 deaths (25%) and HIV to 579 (38%). HTN-related disease was second only to HIV-related disease as a cause of admission and death. Among hypertensives, the most common cause of admission was congestive heart failure (446; 27%) and of death was stroke (147; 49%). In non-hypertensives, HIV-related disease was the most common cause of both admission (2029; 32%) and death (566; 46%). Conclusions HTN-related disease was second only to HIV as a cause of admission to our hospital and in-hospital death. Better strategies for early diagnosis and treatment of HTN are desperately need in sub Saharan Africa to prevent this morbidity and mortality. Building HTN screening and treatment on top of the extensive infrastructure for HIV disease may be a reasonable approach.

Download Full-text

Adjuvant hypofractionated partial-brain radiation therapy for pediatric Ewing sarcoma brain metastases: case report

Journal of Neurosurgery Pediatrics ◽

10.3171/2015.8.peds15313 ◽

2016 ◽

Vol 17 (4) ◽

pp. 434-438 ◽

Cited By ~ 1

Author(s):

Ritchell van Dams ◽

Henry S. Park ◽

Ahmed K. Alomari ◽

Adele S. Ricciardi ◽

Harini Rao ◽

...

Keyword(s):

Radiation Therapy ◽

Case Report ◽

Ewing Sarcoma ◽

Tumor Resection ◽

Symptomatic Treatment ◽

Reasonable Approach ◽

Inflammatory Changes ◽

Brain Radiation ◽

The Brain

This case report demonstrates that hypofractionated partial-brain radiation therapy with limited margins is a reasonable approach following gross tumor resection of Ewing sarcoma metastases to the brain. The patient presented with 2 intracranial metastases treated with gross-total resection followed by radiation therapy to 30 Gy in 5 fractions. The patient experienced symptomatic treatment-related inflammatory changes with resolution after receiving dexamethasone. He remains alive at 21 months of follow-up with no evidence of disease.

Download Full-text

The Utility of Iron Chelators in the Management of Inflammatory Disorders

Mediators of Inflammation ◽

10.1155/2015/516740 ◽

2015 ◽

Vol 2015 ◽

pp. 1-12 ◽

Cited By ~ 20

Author(s):

C. Lehmann ◽

S. Islam ◽

S. Jarosch ◽

J. Zhou ◽

D. Hoskin ◽

...

Keyword(s):

Inflammatory Diseases ◽

Iron Chelation ◽

Iron Regulation ◽

Human Organism ◽

Iron Availability ◽

Pathological Conditions ◽

Reasonable Approach ◽

Potential Impact ◽

Pharmaceutical Agents

Since iron can contribute to detrimental radical generating processes through the Fenton and Haber-Weiss reactions, it seems to be a reasonable approach to modulate iron-related pathways in inflammation. In the human organism a counterregulatory reduction in iron availability is observed during inflammatory diseases. Under pathological conditions with reduced or increased baseline iron levels different consequences regarding protection or susceptibility to inflammation have to be considered. Given the role of iron in development of inflammatory diseases, pharmaceutical agents targeting this pathway promise to improve the clinical outcome. The objective of this review is to highlight the mechanisms of iron regulation and iron chelation, and to demonstrate the potential impact of this strategy in the management of several acute and chronic inflammatory diseases, including cancer.

Download Full-text