scholarly journals Antimicrobial Susceptibility of Acinetobacter baumannii complex Isolated From Different Clinical Samples In A Tertiary Care Hospital

2017 ◽  
Vol 1 (1) ◽  
Author(s):  
Guckan R ◽  
Kilinc C ◽  
Demir AD ◽  
Capraz A ◽  
Yanik K
Keyword(s):  
Acinetobacter Baumannii ◽  
Antimicrobial Susceptibility ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Samples ◽  
Care Hospital ◽  
Acinetobacter Baumannii Complex

scholarly journals Prevalence of nonfermentative gram-negative bacilli and their antimicrobial susceptibility profiles in a tertiary care hospital of Eastern India

2018 ◽  
Vol 5 (2) ◽  
pp. 366 ◽  
Author(s):  
Mandira Sarkar ◽  
Jagadananda Jena ◽  
Dipti Pattnaik ◽  
Bandana Mallick
Keyword(s):  
Antimicrobial Susceptibility ◽  
Nosocomial Infections ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Burkholderia Cepacia Complex ◽  
Diffusion Method ◽  
Clinical Samples ◽  
Care Hospital ◽  
Isolation And Identification ◽  
Gram Negative

Background: Nonfermentative gram-negative bacilli (nonfermenters) have emerged as a major concern for nosocomial infections. They exhibit resistance not only to the beta-lactam and other group of antibiotics but also to carbapenems. This study was undertaken to know the prevalence of nonfermenters from clinical samples along with their antimicrobial susceptibility profile.Methods: A cross-sectional study over a period of 21 months in the microbiology laboratory of a tertiary care hospital was done. Clinical samples were processed by conventional bacteriological methods for isolation and identification. Susceptibility testing was done by Kirby-Bauer disc diffusion method as recommended by Clinical and Laboratory Standard Institute.Results: 411 nonfermenters (13.18%) were isolated from 3116 culture positive clinical samples. Out of these nonfermenters, most were Acinetobacter baumannii (51.34%) followed by Pseudomonas aeruginosa (42.09%), Burkholderia cepacia complex (4.38%) and others (2.19%). Others included Burkholderia pseudomellei, Acinetobacter lwoffii and Stenotrophomonas maltophilia. Highest sensitivity to gentamicin and amikacin were shown by A. baumannii and P. aeruginosa respectively while both were mostly resistant to ceftriaxone. Burkholderia and Stenotrophomonas species showed 100% sensitivity to cotrimoxazole. A. baumannii was the most prevalent nonfermenter in intensive care units.Conclusions: Timely identification of nonfermenters and monitoring their susceptibility patterns will help in proper management of infections caused by them. Improved antibiotic stewardship and infection control measures should be implemented to prevent nosocomial infections and spread of drug resistant nonfermenters.

scholarly journals Clinical Profile and Susceptibility Patterns of Infections by Elizabethkingia Species in a Tertiary Care Hospital, Bhubaneswar, Odisha

2021 ◽  
Vol 8 (21) ◽  
pp. 1624-1629
Author(s):  
Preety Mishra ◽  
Dipti Pattnaik ◽  
Kalpana Mund ◽  
Subhra Snigdha Panda ◽  
Smrutilata Sahoo ◽  
...  
Keyword(s):  
Nosocomial Infection ◽  
Antimicrobial Susceptibility ◽  
Tertiary Care Hospital ◽  
Tertiary Care ◽  
Clinical Profile ◽  
Clinical Samples ◽  
Care Hospital ◽  
Susceptibility Pattern ◽  
Antimicrobial Susceptibility Pattern ◽  
Elizabethkingia Meningoseptica

BACKGROUND Elizabethkingia meningoseptica is an emerging pathogen causing meningitis, pneumonia, endocarditis, bacteremia, sepsis, wound & soft tissue infections, abdominal, respiratory and ocular infections, dialysis associated peritonitis and prosthesis associated septic arthritis, especially in immunodeficient hosts of various age groups. The prevalence of nosocomial infection by E. meningoseptica has increased, predominantly in patients with invasive procedures, prior use of broad-spectrum antimicrobial and co-morbid conditions. We wanted to determine the prevalence of Elizabethkingia meningoseptica among the clinical samples processed in our laboratory and their antimicrobial susceptibility pattern. METHODS This observational study was conducted in patients admitted to a tertiary care hospital, from October 2017 to October 2020. The study subjects were selected on positive bacterial culture reports after excluding patients of less than 18 years of age and their demographic and clinical features were obtained from their medical records. Blood samples were processed by BacT/Alert. VITEK-2 system was used to identify the bacteria and their antimicrobial susceptibility pattern. RESULTS Among the 3532 clinical samples processed, 16 (0.45 %) bacterial isolates were Elizabethkingia meningoseptica. Out of them, 5 (31.25 %) were from blood and 11 (68.75 %) were from endotracheal tubes. More number of cases 6 (38 %) were seen in the age group of 61 - 70 years. Most of the patients were on mechanical ventilation with common co-morbid condition associated was cardiovascular diseases 11 (68 %). E. meningoseptica was most often sensitive to nalidixic acid and ciprofloxacin (50 %), tigecycline 4 (30 %), minocycline 3 (18 %), cotrimoxazole 2 (15 %), piperacillin-tazobactam 1 (13 %) and minocyclin (18.75 %). CONCLUSIONS Infection with E. meningoseptica is clinically important as the organism causes nosocomial infection and is intrinsically resistant to multiple antibiotics, such as βlactams, aminoglycosides, tetracycline, tigecycline, colistin, chloramphenicol and carbapenems. Early diagnosis and prompt treatment is required to prevent the morbidity and mortality. KEYWORDS Elizabethkingia Meningoseptica, Antimicrobial Susceptibility, Clinical Profile

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