scholarly journals Tofacitinib as a Therapeutic Option in the Treatment of Refractory Scleritis: A Case Report

2021 ◽  
Vol 9 (1) ◽  
Author(s):  
Markus DV ◽  
Canelas Beer SM ◽  
Moca Trevisani VF
Keyword(s):  
Case Report ◽  
Therapeutic Option

scholarly journals Extraocular muscle repositioning as the last therapeutic option for a patient with a severe course of Graves’ Ophthalmopathy: a case report

2018 ◽  
Vol 18 (1) ◽  
Author(s):  
Andrea Rau ◽  
Matthias Klopfer ◽  
Niklas Rommel ◽  
Mechthild Rau-Fornefeld ◽  
Andreas Kolk
Keyword(s):  
Case Report ◽  
Extraocular Muscle ◽  
Therapeutic Option ◽  
Graves Ophthalmopathy

scholarly journals Case Report. Extracorporeal Membrane Oxygenation in Nivolumab Associated Pneumonitis

2017 ◽  
Vol 3 (2) ◽  
pp. 84-88
Author(s):  
Thomas-Michael Schneider ◽  
Friederike Klenner ◽  
Franz Brettner
Keyword(s):  
Case Report ◽  
Extracorporeal Membrane Oxygenation ◽  
Therapeutic Option ◽  
High Dose ◽  
Great Success ◽  
Case Presentation ◽  
Computed Tomographic ◽  
Rehabilitation Hospital ◽  
Membrane Oxygenation ◽  
History Of

Abstract Background: Newly approved immunotherapeutic agents, like CTLA-4 inhibitors and antibodies against PD-1, are a promising therapeutic option in cancer therapy. Case presentation: A 74-year-old man, with a history of advanced stage melanoma and treatment with ipilimumab, pembrolizumab and nivolumab, was admitted to the hospital due to respiratory failure with hypoxemia and dyspnoea. He rapidly developed severe acute respiratory distress syndrome (ARDS), which required treatment in the intensive care unit which included mechanical ventilation and extracorporeal membrane oxygenation (ECMO). Computed tomographic imaging (CT) showed signs of a pneumonitis, with an ARDS pattern related to the use of PD-1 antibodies. Treating the patient with high-dose immunosuppressive steroids led to an overall improvement. He was transferred to a rehabilitation hospital and subsequently to his home. Discussion and conclusion: This is a unique case report of a patient suffering a grade 4 adverse event under nivolumab who survived having been treated with ECMO. It highlights the possibility of associated adverse reactions as well as the use of ECMO in palliative care patients. ECMO can be of great success even in patients with malignancies, but careful decision making should be done on a case by case basis.

scholarly journals Management of tubal ectopic pregnancy with methotrexate in the setting of symptomatic Coronavirus disease 2019 (COVID-19): A case report

2021 ◽  
Vol 13 (3) ◽  
pp. 277-281
Author(s):  
N.M. Millan ◽  
J Morano ◽  
L Florez ◽  
J Carugno ◽  
C.A. Medina
Keyword(s):  
Case Report ◽  
Literature Review ◽  
Supportive Care ◽  
Medical Management ◽  
Patient Management ◽  
Therapeutic Option ◽  
Careful Consideration ◽  
Management Options ◽  
Tubal Ectopic Pregnancy ◽  
Ectopic Pregnancies

Background: Coronavirus Disease 2019 (COVID-19) represents a complex therapeutic challenge. As the pandemic progresses, patients are presenting with ectopic pregnancies (EPs) and symptomatic COVID-19. Objective: We present the management of a patient with multiple medical comorbidities and tubal EP in the setting of severe symptomatic COVID-19 infection where all management options were precluded. Methods: Case report with literature review of management of tubal EP in the setting of severe symptomatic COVID-19 infection. Result: After careful consideration of options, the patient underwent successful medical management with methotrexate while receiving supportive care for COVID-19. Conclusions: Methotrexate proved to be the safest therapeutic option in this patient. Management of patients with severe COVID-19 and gynaecologic emergencies should be individualised and carefully reviewed with evolving knowledge of COVID-19.

scholarly journals Fractional laser and laser assisted corticosteroid delivery for hypertrophic scars in thermal burns

2019 ◽  
Author(s):  
Ni Putu Susari Widianingsih ◽  
Cita Rosita S. Prakoeswa
Keyword(s):  
Clinical Trial ◽  
Case Report ◽  
Therapeutic Option ◽  
Burn Patients ◽  
Hypertrophic Scars ◽  
Fractional Laser ◽  
Laser Technology ◽  
Thermal Burns ◽  
Post Operative Period ◽  
Other Substances

The unprecedented survival of individuals who sustain acute burns and other trauma has increased the necessity for effective modalities in the treatment and rehabilitation of patients. Hypertrophic scars and contractures are common following thermal burns injury. Cutaneous scars can be complex and thus the approach to therapy is often multimodal with only moderate success. Intralesional corticosteroids have long been a main treatment of hypertrophic and restrictive scars. Recent advance in laser technology and applications now provide additional options for improvements in function, symptoms, and cosmesis. The ablative zones created by fractional ablative lasers may also be used in the immediate post-operative period to enhance delivery of drugs and other substances. This case report shows the successful use of fractional laser assisted corticosteroid to treat burn scars. It is need more extensive clinical trial to prove this method can be a therapeutic option for the extensive cutaneous scarring in burn patients.

scholarly journals A Case of Severe Panuveitis Associated with Psoriasis Vulgaris Successfully Treated with Infliximab

2016 ◽  
Vol 7 (1) ◽  
pp. 191-194 ◽  
Author(s):  
Yuri Sakurai ◽  
Kenichi Namba ◽  
Kazuomi Mizuuchi ◽  
Toshihumi Nomura ◽  
Susumu Ishida
Keyword(s):  
Case Report ◽  
Topical Corticosteroid ◽  
Psoriasis Vulgaris ◽  
Therapeutic Option ◽  
Anterior Segment ◽  
Corticosteroid Treatment ◽  
Intraocular Inflammation ◽  
Posterior Segment ◽  
Retinal Neovascularization ◽  
Short Time

Purpose: Uveitis associated with psoriasis vulgaris is usually seen as an anterior segment inflammation, and it is very rare that the inflammation extends to the posterior segment. We herein report a case of severe panuveitis associated with psoriasis vulgaris presenting as retinal neovascularization, leading to vitreous hemorrhages that were successfully treated with infliximab (IFX). Case Report: A 27-year-old male with psoriasis vulgaris was referred to our hospital due to prolonged severe uveitis OU. He showed a severe anterior chamber inflammation with fibrin formation and total posterior iris synechia OU. With topical corticosteroid treatment, these conditions were relieved for a short time; however, the intraocular inflammation was exacerbated with vitreous hemorrhages caused by retinal neovascularization OS. After the administration of IFX therapy, the intraocular inflammation and retinal neovascularization was resolved, and so far, no severe recurrences have been seen for 3 years with the therapy. Conclusion: When we see patients with severe panuveitis associated with psoriasis extending to the posterior segment, IFX treatment may be a good therapeutic option.

scholarly journals Could Tocilizumab be an Attractive Therapeutic Option for Elderly Patients with Severe COVID-19? A Case Report

2020 ◽  
Vol 40 (11) ◽  
pp. 1085-1088
Author(s):  
Caroline Streicher ◽  
Xavier Engalenc ◽  
Marion Gaudin ◽  
Guillaume Vignaud ◽  
Annick Daulange ◽  
...  
Keyword(s):  
Case Report ◽  
Elderly Patients ◽  
Therapeutic Option

scholarly journals Sildenafil as a Therapeutic Option for Digital Ischemic Ulceration: Case Report

2015 ◽  
Vol 40 (5) ◽  
pp. 890-893 ◽  
Author(s):  
Swenn Maxence Krähenbühl ◽  
Michele Depairon ◽  
Marguerite Faure ◽  
Naik Vietti Violi ◽  
Lee Ann Applegate ◽  
...  
Keyword(s):  
Case Report ◽  
Therapeutic Option

scholarly journals Case Report: Adult Post-COVID-19 Multisystem Inflammatory Syndrome and Thrombotic Microangiopathy

2021 ◽  
Vol 12 ◽  
Author(s):  
Idris Boudhabhay ◽  
Marion Rabant ◽  
Lubka T. Roumenina ◽  
Louis-Marie Coupry ◽  
Victoria Poillerat ◽  
...  
Keyword(s):  
Renal Function ◽  
Case Report ◽  
Thrombotic Microangiopathy ◽  
Therapeutic Option ◽  
Dramatic Improvement ◽  
Case Presentation ◽  
Complement Inhibition ◽  
Clinical Series ◽  
Inflammatory Syndrome

BackgroundThe coronavirus disease 2019 (COVID-19) pandemic has affected millions of people worldwide. A clinical series of Kawasaki-like multisystem inflammatory syndrome (MIS), occurring after SARS-CoV-2 infection, have been described in children (MIS-C) and adults (MIS-A), but the pathophysiology remains unknown.Case PresentationWe describe a case of post-COVID-19 MIS-A in a 46-year-old man with biopsy-proven renal thrombotic microangiopathy (TMA). Specific complement inhibition with eculizumab was initiated promptly and led to a dramatic improvement of renal function.ConclusionOur case suggests that that TMA could play a central role in the pathophysiology of post-COVID-19 MIS-A, making complement blockers an interesting therapeutic option.

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