Risk Factors in Cancer Patients

2021 ◽  
Vol 76 (5) ◽  
pp. 465-475
Author(s):  
Ekaterina V. Slukhanchuk ◽  
Victoria O. Bitsadze ◽  
Anatoly G. Tyan ◽  
Jamilya Kh. Khizroeva ◽  
Maria V. Tretyakova ◽  
...  
Keyword(s):  
Cancer Patients ◽  
Prothrombotic State ◽  
Central Venous ◽  
Innovative Strategies ◽  
Tumor Patient ◽  
New Horizons ◽  
Factors Associated ◽  
Stage Of Development ◽  
History Of ◽  
The Moment

Numerous studies in recent years have proven that the oncological process is an independent risk factor for thrombosis. For a long period of time and at the moment, research is continuing on the pathogenesis of a prothrombotic state in cancer patients. It was shown that the degree of risk is influenced by such indicators as the histological type of tumor, the stage of development of the disease, surgery, duration and type of anesthesia, chemotherapy, hormonal therapy, age, the presence of central venous catheters, immobilization, thrombophilia, history of thrombosis, infections. Thrombosis in cancer patients is triggered by thrombogenic factors associated with the tumor, patient-associated factors and environmental factors. The tumor cell affects the balance of hemostasis by releasing procoagulant substances, profibrinolytic, proproteolytic and proaggregant activity, expression of adhesion molecules, secretion of proinflammatory and proangiogenic cytokines; new participants in the process have also been identified. Studies have confirmed the fact that inflammation and thrombosis are inextricably linked with each other and play an important role in the progression of the disease and metastasis. All this opens up new horizons for the development of modern innovative strategies for treating cancer patients and increasing survival.

scholarly journals Residential mobility among adult cancer survivors in the United States

2020 ◽  
Vol 20 (1) ◽  
Author(s):  
Bian Liu ◽  
Furrina F. Lee ◽  
Francis Boscoe
Keyword(s):  
Cancer Survivors ◽  
Cancer Patients ◽  
Cancer Diagnosis ◽  
Residential Mobility ◽  
The United States ◽  
School Level ◽  
Factors Associated ◽  
Adult Cancer Survivors ◽  
History Of ◽  
History Of Cancer

Abstract Background While residential mobility affects people’s health, the dynamic of neighborhood tenure and its associated factors among cancer patients and survivors have not been studied in detail. This cross-sectional study aimed to identify sociodemographic factors associated with neighborhood tenure and relocation after the first cancer diagnosis among U.S. adult cancer survivors and patients. Methods Based on a nationally representative sample of non-institutionalized civilian adults (≥18 years, n = 185,637) from the 2013–2018 National Health Interview Survey, we compared neighborhood tenure between adults with and without a history of cancer, and identified factors associated with their neighborhood tenure and relocation after the first cancer diagnosis, using propensity score matching, and logistic regression models with survey design incorporated. Results Among adults with cancer (9.0%), 39.6% had a neighborhood tenure ≤10 years (vs. 61.2% among those without cancer), and 25.6% (equivalent to 5.4 million) relocated after their first cancer diagnosis. The odds of having shorter neighborhood tenure was higher among the cancer group in the propensity-matched samples (odds ratio = 1.05; 95% CI: 1.05–1.06; n = 17,259). Among cancer survivors, the odds of neighborhood relocation were negatively associated with increasing age, perceived neighborhood social cohesion, having high school level education, and being married; while positively associated with having family income below the poverty threshold, being uninsured, and living in non-Northeast regions. Conclusions High residential mobility was found among a sizable proportion of adults with a history of cancer, and was associated with multiple socioeconomic factors. Incorporating and addressing modifiable risk factors associated with residential mobility among cancer patients and survivors may offer new intervention opportunities to improve cancer care delivery and reduce cancer disparities.

scholarly journals Prevalence, Risk Factors, and Management of Stroke in Patients with COVID-19 Infection: A Review

2021 ◽  
pp. 10-17
Author(s):  
Sidra Shahid Mubasher ◽  
Humera Batool ◽  
Emen Udo Kierian ◽  
Khatja Batool
Keyword(s):  
Risk Factors ◽  
Older Patients ◽  
Care Center ◽  
Prothrombotic State ◽  
Stroke Patients ◽  
Stroke Incidence ◽  
Health Care Center ◽  
Factors Associated ◽  
Inflammatory Conditions ◽  
History Of

In the current pandemic, it is imperative to comprehend and advance a search forward to explore the pathogenesis of stroke in COVID-19 infected patients. In this review, we have discussed the prevalence of stroke in COVID-19 infected patients and different risk factors associated with the stroke in COVID-19. We also presented a comprehensive review on management of Stroke Patients during the COVID-19 pandemic. The COVID-19 positive patients with stroke should be treated in a designated COVID-19 health care center as per the guidelines. Study also showed that older patients with a history of cardiovascular diseases, prothrombotic state, smoking, and infection significantly had a higher likelihood of stroke incidence. The study revealed that effective treatment of COVID-19 and reduction of the inflammatory conditions may seem to be the way forward to minimize the symptomatic stroke associated with COVID-19 infection, and rehabilitation of Stroke patients should be optimal during a pandemic.

Natural history of malignant bone disease in renal cancer: Final results of an Italian bone metastases survey.

2012 ◽  
Vol 30 (15_suppl) ◽  
pp. 4627-4627 ◽  
Author(s):  
Daniele Santini ◽  
Giuseppe Procopio ◽  
Camillo Porta ◽  
Calogero Mazzara ◽  
Sandro Barni ◽  
...  
Keyword(s):  
Natural History ◽  
Bone Metastases ◽  
Cancer Patients ◽  
Median Time ◽  
Median Survival ◽  
Renal Cancer ◽  
Bone Disease ◽  
Control Group ◽  
History Of ◽  
The Moment

4627 Background: bone metastases (mts) are an emerging clinical problem in renal cancer patients related to survival increase. We report the final data of largest survey never published in literature. Methods: 398 renal cancer patients (pts) with evidence of bone mts, all died at the moment of study inclusion, have been included. Clinico-pathological data, data on survival and Skeletal Related Events (SRE) data and skeletal related therapies have been collected and statistically analyzed. Results: 286 males/112 females; median age: 63 (16-87); pts with bone mts at the moment of renal cancer diagnosis: 31.4%; pts with single bone mts: 31.1%. Type: lytic 77%, mixed: 14.6%, blastic: 7.6 %. Sites: spine (65.8%), pelvis (38.4%), long bones (31.6%), other (18.8%). Median time to bone mts: 8 months (0-288) (all patients); 24 months (1-288) (pts without bone mts at diagnosis). Pts with at least 1 SRE: 71.1%. Types of SREs: pathologic fracture (12.6%), radiotherapy (61.8%), spinal compression (7.6%), bone surgery (14.8%), hypercalcaemia (3.2%). Median number of SRE for patient: 1 (0-4). Median time to first SRE: 2 (0-72), to second SRE: 4 (0-113), to third SRE: 11 (1-108). Median survival after bone mts diagnosis: 12 (1-178). Median survival after first SRE: 10 (0-144). Median survival in pts with at least one SRE: 14 (1-178); median survival in pts without SREs: 9 (0-62). In according with MKSCC criteria median time to skeletal disease was in patients with good prognosis was 24 (0-288), intermediate was 5 (0-180) and poor prognosis was 0 (0-77). A total of 168 pts received zoledronic acid until performance status worsening or death. 162 pts have been analysed as control group. The median time to first SRE in the zoledronic treated pts was 3 mths (0-101) compared with 1 mth (0 - 25) in the control group (p< 0.05). 5 cases of ONJ have been diagnosed. Conclusions: The present survey is the largest descriptive study concerning the natural history of bone disease in renal cancer patients. The effects of biological therpies on bone met will be presented during the meeting.

scholarly journals Risk Factors of Thromboembolic Disease in Men with Prostate Cancer: Report from a Hispanic Population

Blood ◽  
2018 ◽  
Vol 132 (Supplement 1) ◽  
pp. 5025-5025
Author(s):  
Rodrigo Luna-Santiago ◽  
Maria T Bourlon ◽  
Ariel Jasqui-Bucay ◽  
Alan Jasqui-Bucay ◽  
Oscar Manuel Fierro-Angulo ◽  
...  
Keyword(s):  
Prostate Cancer ◽  
Risk Factors ◽  
Multivariate Analysis ◽  
Hip Fracture ◽  
Central Venous Catheter ◽  
Venous Thrombosis ◽  
Cancer Patients ◽  
Venous Catheter ◽  
Central Venous ◽  
History Of

Abstract Introduction Prostate cancer is the most frequent malignant neoplasm diagnosed in men worldwide. Patients with prostate cancer have higher rates of thrombotic events when compared with other groups of cancer patients; that can be explained because of the presence of multiple risk factors such as age, histopathology, type of therapy, and associated comorbidities. The aim of this study was to determine the risk factors related to development of thrombosis in patients with prostate cancer in a tertiary care center. Methods Retrospective cohort study that included patients ≥18yo diagnosed with prostate cancer at our institution between 2014 and 2017. Univariate and multivariate analysis were performed including all previously described thrombosis risk factors in cancer patients. Results A total of 101 patients were included. Median age was 72 years (52-92). A total of 23 patients (22.8%) presented with a thrombotic event. Regarding baseline characteristics, patients with thrombosis were older (77 vs. 71 years; p=.015), had lower levels of HDL (40.4 vs. 48 mg/dL; p=.033), and a higher prevalence of primary hypertension (65.2% vs.34.6%; p=.009). In patients with thrombosis, 52.2% (n=12) were venous thrombosis and 47.8% (n=11) were arterial. The most common events were pulmonary thromboembolism (n=7; 58.3%) for venous thrombosis and acute coronary syndromes (n=6; 54.5%) for arterial events. In univariate analysis risk factors related to the development of thrombosis were: prostration > 3 days (p=.039), immobility (p=.023), central venous catheter (p=.004), congestive heart failure (p=.021), history of TE (p=.021), major surgery (p=.031) and hip fracture (p=.021). Table 1. On multivariate analysis factors that remained statistically significant were: central venous catheter OR 8.8 (CI 95% 2.2-35.7, p=.002), previous thrombosis OR 10.3 (CI 95% 1.5-72.8, p=.020), and hip fracture OR 8.5 (CI 95% 1.2-63.5,p=.037). Conclusions In conclusion, our study confirms findings from previous studies regarding factors that significantly predispose cancer patients to thrombosis development. Considering our population age, it is not surprising that risk factors in patients with prostate cancer were mainly related to the presence of other comorbiditiesparticularly cardiovascular and atherothrombotic disease. The main risk factor was history of previous thrombosis, suggesting that closer and prolonged anticoagulation therapy should be consider. Multicenter prospective studies most be urged in our population to asses and validate risk factors, and design prognostic scores that can help on determining which patients could be candidates to early intervention modifying preexisting factors and/or receiving prophylactic dose of anticoagulants. Disclosures No relevant conflicts of interest to declare.

Experiences of cancer patients with outpatient care in the USA: a population-based study

2020 ◽  
Vol 9 (13) ◽  
pp. 959-967
Author(s):  
Omar Abdel-Rahman
Keyword(s):  
Logistic Regression ◽  
Regression Analysis ◽  
Cancer Patients ◽  
Outpatient Care ◽  
Healthcare Providers ◽  
Multivariable Logistic Regression Analysis ◽  
Factors Associated ◽  
The Usa ◽  
History Of ◽  
History Of Cancer

Aim: To evaluate the patterns of cancer patients-assessed quality of outpatient care in the USA. Materials & methods: Medical Expenditure Panel Survey datasets for the years 2011, 2013, 2015 and 2017 were accessed and adult participants with a history of cancer diagnosis were reviewed. Participants’ assessments of different quality indicators of healthcare providers were reviewed. Multivariable logistic regression analysis for factors associated with a better overall rating of healthcare was then conducted. Results: A total of 8050 participants with a history of cancer were included. Within multivariable logistic regression analysis, factors associated with the better rating of healthcare included; older age (odds ratio [OR]: 1.017; 95% CI: 1.010–1.025), higher income OR (OR: 2.385; 95% CI: 1.735–3.277) and better self-reported health status (OR: 6.691; 95% CI: 3.928–11.396). Conclusion: Cancer patients with older age, higher income and better health status were more likely to be satisfied with the outpatient care they received. The biggest area for potential improvement of patient satisfaction seems to be related to the time spent with healthcare providers.

scholarly journals Video Blog Advertising: Feedback Analysis

2018 ◽  
Vol 7 (3.14) ◽  
pp. 336
Author(s):  
M V. Gundarin ◽  
A A.I. Zotova ◽  
I Y. Ilina ◽  
E E. Nakhratova ◽  
I V. Makarova
Keyword(s):  
Information Technologies ◽  
The Internet ◽  
Social Aspect ◽  
Feedback Analysis ◽  
Political Processes ◽  
Stage Of Development ◽  
The Social ◽  
Gradual Development ◽  
History Of ◽  
The Moment

In recent years, a new market trading in cryptocurrencies and instruments based on them has been formed. The market of this paper The Internet, as a result of the gradual development of information technologies, has become an advanced communicative means resulting in totally new communication forms. At this stage of development, Internet technologies promote social growing-up of a person in communities. At this point in the history of the Internet, we face the problem of studying the social aspect of virtual reality. Participants in social and political processes have shown their interest in investigating the Internet phenomenon, including its role in different spheres of public life, since the moment of its formation. Such communicative means as video blogs are of key importance. The urgency of this issue is multifaceted. Thus, the article presents results of the content analysis of the target audience feedback referred to video blog advertising. The findings enable to optimize advertisers’ use of such channel of promotion as video blogs.  

The Basics for Comprehension of Adhesive Process Formation in Abdominal Cavity. Perioperative Prevention by means of Anti-Adhesive Drugs (Review of Literature)

10.12737/5929 ◽  
2014 ◽  
Vol 21 (3) ◽  
pp. 169-173 ◽  
Author(s):  
Кондратович ◽  
L. Kondratovich
Keyword(s):  
Abdominal Cavity ◽  
Reproductive Technologies ◽  
Time Interval ◽  
Review Of Literature ◽  
Stage Of Development ◽  
Process Formation ◽  
History Of ◽  
The Moment

The review of literature presents a brief history of study of adhesive process from the beginning of XX century to the present, the modern concepts of the pathogenesis of adhesive process in the abdominal cavity after surgery on the organs of the small pelvis, taking into account the development of molecular biology, biochemistry, immunology. Problems of study of adhesive process are relevant at this stage of development of surgery of high reproductive technologies and the use of surgical energies, careful approach to the tissues. The processes that occur in the peritoneum after surgery are described in detail. The mechanism of neoangiogenesis in the newly formed growths is presented in detail, conditionally and schematically. The role of growth factors of cytokines, fibrinolysis in the process of formation of adhesions is reflected. The sequence of processes leading to the formation of adhesions is presented in the time interval: from the moment of peritoneal damage during operation up to 12 days of the postoperative period, the time of formation of fibrous adhesions. The structure of connective tissue fibres by components fibres, i.e. the structure of collagen fibers of different types is examined. The review presents conditional classification of anti-adhesive drugs with description of the properties and characteristics by the method of their application, the composition of constituent substances, the forms of release.

How Valid are Patient Reports of Family History of Illness?

1980 ◽  
Vol 19 (03) ◽  
pp. 162-164 ◽  
Author(s):  
Rachel Harris ◽  
W. Margaret ◽  
Kathleen Hunter
Keyword(s):  
Family History ◽  
Medical History ◽  
Cancer Patients ◽  
Cause Of Death ◽  
Death Certificate ◽  
Recall Rate ◽  
Patient Reports ◽  
Small Subgroup ◽  
History Of ◽  
Medical Histories

The recall rate of patients’ family medical histories was studied in 200 cancer and non-cancer patients. Data on age and cause of death for parents and grandparents were collected. Although most patients knew the age and cause of death of parents, less than half knew for grandparents. Cancer patients had significantly greater recall for maternally related relatives. A subsample of patients’ family medical histories was compared to death certificate data. Patients’ reports were found to be highly inaccurate. Since only a small subgroup could provide medical history data for grandparents, the generaliz-ability for history of family illness is questioned.

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