scholarly journals Analysis of circulating miRNA levels in coronary heart disease patients with varying degrees of cardiovascular complications risk. correlations with the MSCT-CA data

2020 ◽  
Vol 75 (4) ◽  
pp. 283-291
Author(s):  
Andrey N. Rozhkov ◽  
Dmitriy Yu. Shchekochikhin ◽  
Natalia М. Baulina ◽  
Natalia A. Matveeva ◽  
Olga O. Favorova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Complications ◽  
Demographic Characteristics ◽  
Atherosclerotic Plaques ◽  
Circulating Microrna ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Estimated Risk

Rationale. Cardiovascular diseases remain the leading cause of human death in the world. Studying the role of regulatory non-coding RNAs, which include short single-stranded miRNA molecules, allows a more detailed understanding of the pathological processes underlying the progression of atherosclerosis. Objective to compare the levels of circulating miRNAs in patients with coronary heart disease, confirmed by multislice computed tomography-coronarography (MSCT-CA), with risks of cardiovascular complications and clinical and demographic characteristics. To compare the profiles of circulating miRNAs in groups of patients with stable and unstable atherosclerotic plaques. Methods. MicroRNA levels in the plasma of peripheral blood of patients with coronary heart disease were determined using the miScript miRNA PCR Array MIHS-105Z kit (Qiagen). The significance of differences in miRNA levels between the compared groups was determined using the MannWhitney U-test. The correlations of the levels of circulating miRNAs with clinical and demographic parameters were evaluated using the Spearman correlation coefficient. Risk assessment of cardiovascular complications in these patients was carried out using validated scales (ACC/AHA, Framinghm, SCORE, MESA). Atherosclerotic plaque stability was evaluated using MSCT-CA. Results. The study showed a significant (p 0.05) decrease in miR-16, miR-211, miR-195 miRNA levels in the plasma of patients with coronary heart disease, which correlated with an increase in cardiac vascular risk (CVR) according to ACC/AHA, Framingham and MESA. When comparing groups of patients with stable and unstable atherosclerotic plaques, the latter revealed an increase in the level of let-7b-5p circulating microRNA (p 0.05). Conclusion. Significant associations of the three studied microRNAs with the estimated risk of CVR were identified. It is important to find circulating let-7b-5p in a group of patients with unstable atherosclerotic plaques. Correlations were established between the levels of circulating microRNAs and clinical and demographic characteristics of patients. The study shows the involvement of some microRNAs in the regulation of atherosclerosis.

Inflammation and atherosclerosis in rheumatoid arthritis

2005 ◽  
Vol 7 (7) ◽  
pp. 1-24 ◽  
Author(s):  
Robert J. Stevens ◽  
Karen M.J. Douglas ◽  
Athanasios N. Saratzis ◽  
George D. Kitas
Keyword(s):  
Rheumatoid Arthritis ◽  
Risk Factors ◽  
Coronary Heart Disease ◽  
Heart Disease ◽  
Individual Risk ◽  
Atherosclerotic Plaques ◽  
The Metabolic Syndrome ◽  
Inflammatory Processes ◽  
Individual Risk Factors

Rheumatoid arthritis (RA) associates with increased cardiovascular mortality. This appears to be predominantly due to ischaemic causes, such as myocardial infarction and congestive heart failure. The higher prevalence of cardiac ischaemia in RA is thought to be due to the accelerated development of atherosclerosis. There are two main reasons for this, which might be inter-related: the systemic inflammatory load, characteristic of RA; and the accumulation in RA of classical risk factors for coronary heart disease, which is reminiscent of the metabolic syndrome. We describe and discuss in the context of RA the involvement of local and systemic inflammatory processes in the development and rupture of atherosclerotic plaques, as well as the role of individual risk factors for coronary heart disease. We also present the challenges facing the clinical and scientific communities addressing this problem, which is receiving increasing attention.

Matrix metalloproteinase-1, -8, -9 and the risk of cardiovascular complications in patients with CHD before and after myocardial revascularization

2017 ◽  
pp. 37-45
Author(s):  
Е.В. Шкорик ◽  
Е.В. Маркелова ◽  
А.А. Силаев ◽  
Б.И. Гельцер ◽  
А.А. Семенихин ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Artery Bypass ◽  
Myocardial Revascularization ◽  
Cardiovascular Complications ◽  
Group Differences ◽  
Matrix Metalloproteinase 1 ◽  
Before And After ◽  
Detection Of Biomarkers

До сих пор существует потребность в поиске биомаркеров для раннего прогнозирования и диагностики сердечно-сосудистых осложнений (ССО) у пациентов с ИБС. Цель - определение роли матриксных металлопротеиназ (ММП-1, 8, 9) в риске развития CCО у пациентов с ИБС до и после аортокоронарного шунтирования (АКШ). Методика. В исследование включены 75 больных с ИБС до и после реваскуляризации миокарда методом АКШ, из них 40 мужчин и 35 женщин в возрасте от 45 до 74 лет. Пациенты были разделены на 2 группы: I группа - 25 больных с зарегистрированными ССО после АКШ (острый инфаркт миокарда, ишемический инсульт, тромбоэмболия легочных ветвей); II группа - 50 больных с ИБС без осложнений после реваскуляризации миокарда. Забор крови осуществлялся за сутки до операции, в 1-е, 3-и и 10-е сутки после АКШ. Определение уровня ММП-1, -8, -9 проводилось в сыворотке крови методом твердофазного ИФА, с использованием специфических реактивов «RD Diagnostics Inc.», USA. Результаты выражали в нг/мл. Данные представляли в виде медианы и двух квартилей (Me, Q, Q). Внутри и межгрупповые различия оценивали с помощью критерия Манна-Уитни, коэффициента корреляции Спирмена и критерия c в рамках прикладной программы SPSS №16. Статистически значимыми считали различия между показателями при отклонении нулевой гипотезы и уровне значимости p<0,05. Результаты. Выявлено статистически значимое повышение концентрации ММП-1 и ММП-8 у больных в I группе. Не выявлено значимой динамики ММП-9 у пациентов после реваскуляризации миокарда. Заключение. Полученные результаты свидетельствуют, что уровень ММП-1 2,5 нг/мл и более у пациентов с ИБС является диагностическим критерием риска возникновения ТЭ осложнений. Не установлено связи между повышенным содержанием ММП-8 и наличием осложнений у пациентов после операции. Не выявлено значимой динамики ММП-9 у пациентов после реваскуляризации миокарда. There is still a great need for detection of biomarkers for early prediction and diagnosis of cardiovascular complications (CVC) in patients with CHD. Objective: To determine the role of MMP-1, 8, 9 in the risk of CCO in patients with CHD before and after coronary artery bypass grafting (CABG). Methods. The study included 75 patients with coronary heart disease before and after myocardial revascularization by CABG, including 40 men and 35 women aged from 45 to 74 years. Patients were divided into two groups: I group - 25 patients with CVC registered after CABG (acute myocardial infarction, ischemic stroke, pulmonary thromboembolism Branch); II group - 50 patients with coronary heart disease without complications after myocardial revascularization. Blood sampling was performed the day before surgery, on the 1st, 3rd and 10th days after CABG. Determining the level of MMP-1, 8, 9 in the serum was performed by ELISA using reagents specific «RD Diagnostics Inc.», USA. Results are expressed in ng/ml. Data are presented as medians and quartiles of two (Me, Q25, Q75). Within and between-group differences were evaluated using the Mann - Whitney, Spearman correlation coefficient and c

scholarly journals Role of adipokine zinc-α2-glycoprotein in coronary heart disease

2019 ◽  
Vol 317 (6) ◽  
pp. E1055-E1062
Author(s):  
Dandan Huang ◽  
Xiaoxiang Mao ◽  
Jiangtong Peng ◽  
Min Cheng ◽  
Tao Bai ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Foam Cell ◽  
Cell Formation ◽  
Foam Cell Formation ◽  
Atherosclerotic Plaques ◽  
293 Cells ◽  
Anti Inflammatory

Zinc-α2-glycoprotein (AZGP1) is a newly identified adipokine that is associated with lipid metabolism and vascular fibrosis. Although adipokines contribute to lipid dysfunction and its related diseases, including stroke and coronary heart disease (CHD), the role of AZGP1 remains unclear. In this study, the role of AZGP1 in atherosclerosis and CHD was investigated. Serum AZGP1 levels from control ( n = 84) and CHD ( n = 91) patients were examined by ELISA and its relationship with various clinical parameters was analyzed. Immunohistochemistry and immunofluorescence were used to detect the expression of AZGP1 and its receptor in coronary atherosclerotic arteries. THP-1 and human embryonic kidney 293 cells were used to verify its anti-inflammatory role in atherosclerosis. Serum AZGP1 levels in CHD patients were lower than controls ( P < 0.01) and independently associated with CHD prevalence ( P = 0.021). AZGP1 levels also inversely correlated with the Gensini score. Immunohistochemistry and immunofluorescence showed that AZGP1 and its receptor β3-adrenoceptor (β3-AR) colocalized in lipid-rich areas of atherosclerotic plaques, particularly around macrophages. In vitro, AZGP1 had no effect on foam cell formation but showed anti-inflammatory effects through its regulation of JNK/AP-1 signaling. In summary, AZGP1 is an anti-inflammatory agent that can be targeted for CHD treatment.

scholarly journals Circulating MicroRNAs as Potential Biomarkers of Atrial Fibrillation

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Ananília Medeiros Gomes da Silva ◽  
Jéssica Nayara Góes de Araújo ◽  
Renata Caroline Costa de Freitas ◽  
Vivian Nogueira Silbiger
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Noncoding Rnas ◽  
Supraventricular Arrhythmia ◽  
Sample Type ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Noninvasive Biomarkers ◽  
Potential Biomarkers

Atrial fibrillation (AF) is the most common supraventricular arrhythmia in the population. MicroRNAs (small endogenous noncoding RNAs) are attractive candidates as biomarkers for AF, especially considering that miRNAs are stable and are detected within easily accessible biofluids such as blood. In this review, we selected twelve studies (2012 to 2016) that were classified according to the sample type. We aimed to provide an overview of the role of circulating miRNAs in AF and to discuss the variability of the results, seeking to improve the perspective of the use of miRNAs as potential noninvasive biomarkers for this heart disease.

scholarly journals Is there life after acute coronary syndrome?

2021 ◽  
pp. 30-32
Author(s):  
A. V. Yagensky
Keyword(s):  
Coronary Heart Disease ◽  
Acute Coronary Syndrome ◽  
Heart Disease ◽  
Blood Vessels ◽  
Low Density Lipoproteins ◽  
Atherosclerotic Plaques ◽  
Low Density ◽  
Pathogenetic Mechanism ◽  
Coronary Syndrome

The role of coronary heart disease and acute coronary syndrome in the structure of morbidity and mortality of the population of Ukraine cannot be overestimated. The main pathogenetic mechanism of corticosteroids is atherothrombosis, the influence of which is the basis of treatment of patients with coronary heart disease with or without corticosteroids. The effect on the progression of atherothrombosis is possible due to statins, due to slowing the growth of atherosclerotic plaques in blood vessels by reducing the level of low-density lipoproteins in the blood.

scholarly journals Coronary heart disease and inflammation.

2018 ◽  
Vol 96 (8) ◽  
pp. 688-695
Author(s):  
A. A. Kirichenko
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cholesterol Metabolism ◽  
Cardiovascular Complications ◽  
Coagulation System ◽  
Inflammatory Rheumatic Diseases ◽  
Important Place ◽  
Coronary Syndrome ◽  
Anti Inflammatory

The increased content of inflammation markers in the blood is a significant prognostic sign of coronary events in persons with stable or asymptomatic course of coronary heart disease (CHD) and suggests that the inflammation underlying the destabilization of CHD has an independent character and is largely independent of the severity of stenotic lesions of coronary vessels. Activation of the local inflammatory process in the atherosclerotic plaque leads to the destruction of the fibrous capsule in combination with an increase in the activity of cellular and plasma factors of the coagulation system and inhibition of the fibrinolytic system. Cytomegalovirus, Chlamydia pneumoniae, pathogens of periodontal disease are nominated for the role of inducers of inflammatory reactions. The synergistic effect of several pathogens is reflected in the concept of burden of infection (“infectious burden”). Immuno-inflammatory rheumatic diseases are characterized by a high risk of cardiovascular complications. An important place in their prevention is an effective anti-inflammatory therapy: methotrexate, suppressing the formation of interleukin 1ft and tumor necrosis factor a, allows not only to modify the course of the disease, but also to reduce the risk of cardiovascular accidents. Chronic inflammation, as a key element of atherosclerosis pathogenesis, can be caused not only by infectious and immune factors, but also by metabolic factors. The activation of inflammasomes induced by cholesterol crystals in macrophages is an important link between cholesterol metabolism and inflammation in atherosclerotic plaques. Confirmation of the important pathogenetic role of inflammation is to reduce the risk of cardiovascular complications (CVD) on the background of anti-inflammatory therapy. In statin therapy, the decrease in The level of C-reactive protein (CRP) was significantly correlated with the suppression of atherosclerosis progression and a decrease in the risk of SSR, regardless of the degree of lowering the low-density lipoprotein cholesterol level. Taking colchicine in a low dose in patients with stable coronary artery disease, who received standard therapy, reduced the risk of acute coronary syndrome and sudden cardiac death. Secondary prevention of cardiovascular complications by human monoclonal antibodies to interleukin 1ft (kanakinumab) led to a decrease in the risk of SSR regardless of sex, Smoking, and lipid levels.

Modern ideas about the role of hyperuricemia in the pathogenesis of coronary heart disease

2018 ◽  
Vol 2 (1) ◽  
pp. 47-54
Author(s):  
Eleonora TASHKENBAEVA ◽  
◽  
Dilshod TOGAEV ◽  
Farzona KADIROVA ◽  
Shukhrat ZIYADULLAEV ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease

The Role of Mapalus Culture by Minahasa Ethnic in North Sulawesi to the Coronary Heart Disease Incidents

2018 ◽  
Vol 8 (3) ◽  
Author(s):  
Jeini Ester Nelwan ◽  
Edi Widjajanto ◽  
Sri Andarini ◽  
Sasmito Djati ◽  
Oksfriani Jufri Sumampouw
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
North Sulawesi
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