scholarly journals Circulating MicroRNAs as Potential Biomarkers of Atrial Fibrillation

2017 ◽  
Vol 2017 ◽  
pp. 1-7 ◽  
Author(s):  
Ananília Medeiros Gomes da Silva ◽  
Jéssica Nayara Góes de Araújo ◽  
Renata Caroline Costa de Freitas ◽  
Vivian Nogueira Silbiger
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Noncoding Rnas ◽  
Supraventricular Arrhythmia ◽  
Sample Type ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Noninvasive Biomarkers ◽  
Potential Biomarkers

Atrial fibrillation (AF) is the most common supraventricular arrhythmia in the population. MicroRNAs (small endogenous noncoding RNAs) are attractive candidates as biomarkers for AF, especially considering that miRNAs are stable and are detected within easily accessible biofluids such as blood. In this review, we selected twelve studies (2012 to 2016) that were classified according to the sample type. We aimed to provide an overview of the role of circulating miRNAs in AF and to discuss the variability of the results, seeking to improve the perspective of the use of miRNAs as potential noninvasive biomarkers for this heart disease.

scholarly journals Analysis of circulating miRNA levels in coronary heart disease patients with varying degrees of cardiovascular complications risk. correlations with the MSCT-CA data

2020 ◽  
Vol 75 (4) ◽  
pp. 283-291
Author(s):  
Andrey N. Rozhkov ◽  
Dmitriy Yu. Shchekochikhin ◽  
Natalia М. Baulina ◽  
Natalia A. Matveeva ◽  
Olga O. Favorova ◽  
...  
Keyword(s):  
Coronary Heart Disease ◽  
Heart Disease ◽  
Cardiovascular Complications ◽  
Demographic Characteristics ◽  
Atherosclerotic Plaques ◽  
Circulating Microrna ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Estimated Risk

Rationale. Cardiovascular diseases remain the leading cause of human death in the world. Studying the role of regulatory non-coding RNAs, which include short single-stranded miRNA molecules, allows a more detailed understanding of the pathological processes underlying the progression of atherosclerosis. Objective to compare the levels of circulating miRNAs in patients with coronary heart disease, confirmed by multislice computed tomography-coronarography (MSCT-CA), with risks of cardiovascular complications and clinical and demographic characteristics. To compare the profiles of circulating miRNAs in groups of patients with stable and unstable atherosclerotic plaques. Methods. MicroRNA levels in the plasma of peripheral blood of patients with coronary heart disease were determined using the miScript miRNA PCR Array MIHS-105Z kit (Qiagen). The significance of differences in miRNA levels between the compared groups was determined using the MannWhitney U-test. The correlations of the levels of circulating miRNAs with clinical and demographic parameters were evaluated using the Spearman correlation coefficient. Risk assessment of cardiovascular complications in these patients was carried out using validated scales (ACC/AHA, Framinghm, SCORE, MESA). Atherosclerotic plaque stability was evaluated using MSCT-CA. Results. The study showed a significant (p 0.05) decrease in miR-16, miR-211, miR-195 miRNA levels in the plasma of patients with coronary heart disease, which correlated with an increase in cardiac vascular risk (CVR) according to ACC/AHA, Framingham and MESA. When comparing groups of patients with stable and unstable atherosclerotic plaques, the latter revealed an increase in the level of let-7b-5p circulating microRNA (p 0.05). Conclusion. Significant associations of the three studied microRNAs with the estimated risk of CVR were identified. It is important to find circulating let-7b-5p in a group of patients with unstable atherosclerotic plaques. Correlations were established between the levels of circulating microRNAs and clinical and demographic characteristics of patients. The study shows the involvement of some microRNAs in the regulation of atherosclerosis.

scholarly journals Data Integration Reveals the Potential Biomarkers of Circulating MicroRNAs in Osteoarthritis

Diagnostics ◽  
2021 ◽  
Vol 11 (3) ◽  
pp. 412
Author(s):  
Thuan Duc Lao ◽  
Thuy Ai Huyen Le
Keyword(s):  
Target Genes ◽  
Potential Implication ◽  
Circulating Micrornas ◽  
Abnormal Expression ◽  
Online Databases ◽  
Socioeconomic Burden ◽  
Therapeutic Tools ◽  
Potential Use ◽  
Potential Biomarkers

The abnormal expression of circulating miRNAs (c-miRNAs) has become an emerging field in the development of miRNAs-based diagnostic and therapeutic tools for human diseases, including osteoarthritis (OA). OA is the most common form of arthritis leading to disability and a major socioeconomic burden. The abnormal expression of miRNAs plays important roles in the pathogenesis of OA. Unraveling the role of miRNAs in the pathogenesis of OA will throw light on the potential for the development of miRNAs-based diagnostic and therapeutic tools for OA. This article reviews and highlights recent advances in the study of miRNAs in OA, with specific demonstration of the functions of miRNA, especially c-miRNA, in OA pathogenesis as well as its potential implication in the treatment of OA. Based on a systematic literature search using online databases, we figured out the following main points: (1) the integrative systematic review of c-mRNAs and its target genes related to OA pathogenesis; (2) the potential use of c-miRNAs for OA diagnosis purposes as potential biomarkers; and (3) for therapeutic purposes, and we also highlight certain remedies that regulate microRNA expression based on its target genes.

scholarly journals The Role of MicroRNAs in Ovarian Cancer

2014 ◽  
Vol 2014 ◽  
pp. 1-11 ◽  
Author(s):  
Yasuto Kinose ◽  
Kenjiro Sawada ◽  
Koji Nakamura ◽  
Tadashi Kimura
Keyword(s):  
Ovarian Cancer ◽  
Tumor Suppressor Genes ◽  
Target Genes ◽  
Early Stage ◽  
Noncoding Rnas ◽  
Circulating Micrornas ◽  
Gynecological Tumors ◽  
Prevention And Treatment ◽  
Prognostic And Predictive Markers

Ovarian cancer is the most lethal of malignant gynecological tumors. Its lethality may be due to difficulties in detecting it at an early stage and lack of effective treatments for patients with an advanced or recurrent status. Therefore, there is a strong need for prognostic and predictive markers to diagnose it early and to help optimize and personalize treatment. MicroRNAs are noncoding RNAs that regulate target genes posttranscriptionally. They are involved in carcinogenesis, cell cycle, apoptosis, proliferation, invasion, metastasis, and chemoresistance. The dysregulation of microRNAs is involved in the initiation and progression of human cancers including ovarian cancer, and strong evidence that microRNAs can act as oncogenes or tumor suppressor genes has emerged. Several microRNA signatures that are unique to ovarian cancer have been proposed, and serum-circulating microRNAs have the potential to be useful diagnostic and prognostic biomarkers. Various microRNAs such as those in the miR-200 family, the miR-199/214 cluster, or the let-7 paralogs have potential as therapeutic targets for disseminated or chemoresistant ovarian tumors. Although many obstacles need to be overcome, microRNA therapy could be a powerful tool for ovarian cancer prevention and treatment. In this review, we discuss the emerging roles of microRNAs in various aspects of ovarian cancer.

Impact of ischemic heart disease and atrial fibrillation on survival after spontaneous intracerebral hemorrhage

2008 ◽  
Vol 108 (6) ◽  
pp. 1172-1177 ◽  
Author(s):  
Sami Tetri ◽  
Liisa Mäntymäki ◽  
Seppo Juvela ◽  
Pertti Saloheimo ◽  
Juhani Pyhtinen ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Mortality Rate ◽  
Intracerebral Hemorrhage ◽  
Ischemic Heart Disease ◽  
Mortality Rates ◽  
Ischemic Heart ◽  
University Hospital ◽  
Spontaneous Intracerebral Hemorrhage

Object The well-known predictors for increased early deaths after spontaneous intracerebral hemorrhage (ICH) include the clinical and radiological severity of bleeding as well as being on a warfarin regimen at the onset of stroke. Ischemic heart disease and atrial fibrillation may also increase early deaths. In the present study the authors aimed to elucidate the role of the last 2 factors. Methods The authors assessed the 3-month mortality rate in patients with spontaneous ICH (453 individuals) who were admitted to the stroke unit of Oulu University Hospital within a period of 11 years (1993–2004). Results The 3-month mortality rate for the 453 patients was 28%. The corresponding mortality rates were 42% for the patients who had ischemic heart disease and 61% for those with atrial fibrillation on admission. The following independent predictors of death emerged after adjustment for sex and the use of warfarin or aspirin at the onset of ICH: 1) ischemic heart disease (hazard ratio [HR] 1.67, 95% confidence interval [CI] 1.12–2.48, p < 0.02); 2) atrial fibrillation on admission (HR 1.79, 95% CI 1.12–2.86, p < 0.02); 3) the Glasgow Coma Scale score on admission (HR 0.82 per unit, 95% CI 0.79–0.87, p < 0.01); 4) size of hematoma (HR 1.11 per 10 ml, 95% CI 1.07–1.16, p < 0.01); 5) intraventricular hemorrhage (HR 2.62, 95% CI 1.71–4.02, p < 0.01); 6) age (HR 1.04 per year, 95% CI 1.02–1.06, p < 0.01); and 7) infratentorial location of the hematoma (HR 1.93, 95% CI 1.26–2.97, p < 0.01). Conclusions Both ischemic heart disease and atrial fibrillation independently and significantly impaired the 3-month survival of patients with ICH.

Role of Autonomic Tone in the Initiation and Termination of Paroxysmal Atrial Fibrillation in Patients Without Structural Heart Disease

2003 ◽  
Vol 14 (6) ◽  
pp. 559-564 ◽  
Author(s):  
Takeshi Tomita ◽  
Manabu Takei ◽  
Yuko Saikawa ◽  
Takeshi Hanaoka ◽  
Shin‐Ichiroh Uchikawa ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Heart Disease ◽  
Paroxysmal Atrial Fibrillation ◽  
Structural Heart Disease ◽  
Autonomic Tone

scholarly journals THE PROPRIETY ROLE OF CIRCULATING MICRORNAS IN PAROXYSMAL OR PERSISTENT ATRIAL FIBRILLATION

2013 ◽  
Vol 61 (10) ◽  
pp. E311
Author(s):  
Rahul Pidikiti ◽  
Nada Esa ◽  
Menhel Kinno ◽  
Jeanine A. Ward ◽  
Jane E. Freedman ◽  
...  
Keyword(s):  
Atrial Fibrillation ◽  
Persistent Atrial Fibrillation ◽  
Circulating Micrornas

scholarly journals Circulating microRNAs as noninvasive biomarkers for canine Cushing's syndrome

2021 ◽  
Author(s):  
Karin Sanders ◽  
Anouk Veldhuizen ◽  
Hans S. Kooistra ◽  
Adri Slob ◽  
Elpetra P.M. Timmermans-Sprang ◽  
...  
Keyword(s):  
Decision Making ◽  
Clinical Decision Making ◽  
Clinical Decision ◽  
Differentially Expressed ◽  
Circulating Mirnas ◽  
Circulating Micrornas ◽  
Blood Samples ◽  
Healthy Dogs ◽  
Noninvasive Biomarkers ◽  
One Year

Canine Cushing′s syndrome (hypercortisolism) can be caused by a pituitary tumor (pituitary-dependent hypercortisolism; PDH) or a cortisol-secreting adrenocortical tumor (csACT). For both cases, noninvasive biomarkers that could pre-operatively predict the risk of recurrence after surgery would greatly impact clinical decision making. The aim of this study was to determine whether circulating microRNAs (miRNAs) can be used as noninvasive biomarkers for canine Cushing′s syndrome. After a pilot study with 40 miRNAs in blood samples of healthy dogs (n = 3), dogs with PDH (n = 3) and dogs with a csACT (n = 4), we selected a total of 20 miRNAs for the definitive study. In the definitive study, these 20 miRNAs were analyzed in blood samples of healthy dogs (n = 6), dogs with PDH (n = 19, pre- and post-operative samples) and dogs with a csACT (n = 26, pre-operative samples). In dogs with PDH, six miRNAs (miR-122-5p, miR-126-5p, miR-141-3p, miR-222-3p, miR-375-3p and miR-483-3p) were differentially expressed compared to healthy dogs. Of one miRNA, miR-122-5p, the expression levels did not overlap between healthy dogs and dogs with PDH (p = 2.9x10-4), significantly decreased after hypophysectomy (p = 0.013), and were significantly higher (p = 0.017) in dogs with recurrence (n = 3) than in dogs without recurrence for at least one year after hypophysectomy (n = 7). In dogs with csACTs, two miRNAs (miR-483-3p and miR-223-3p) were differentially expressed compared to healthy dogs. Additionally, miR-141-3p was expressed significantly lower (p = 0.009) in dogs with csACTs that had a histopathological Utrecht score of ≥ 11 compared to those with a score of < 11. These results indicate that circulating miRNAs have the potential to be noninvasive biomarkers in dogs with Cushing′s syndrome that may contribute to clinical decision-making.

The role of long noncoding RNAs in atrial fibrillation

Heart Rhythm ◽  
2020 ◽  
Vol 17 (6) ◽  
pp. 1043-1049
Author(s):  
Savalan Babapoor-Farrokhran ◽  
Deanna Gill ◽  
Roozbeh Tarighati Rasekhi
Keyword(s):  
Atrial Fibrillation ◽  
Noncoding Rnas ◽  
Long Noncoding Rnas
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