scholarly journals A Novel, Simple and Green Capillary Electrophoresis Determınation of Sertraline in Pharmaceutical Dosage Forms

2017 ◽  
Vol 4 (45) ◽  
pp. 509-514
Author(s):  
Senem Şanlı ◽  
Elvan Özsoy ◽  
Nurullah Şanlı
Keyword(s):  
Capillary Electrophoresis ◽  
Dosage Forms ◽  
Pharmaceutical Dosage Forms

Determination of six anti-Parkinson drugs using cyclodextrin-capillary electrophoresis method: application to pharmaceutical dosage forms

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17519-17530 ◽  
Author(s):  
Abdallah M. Zeid ◽  
Jenny Jeehan M. Nasr ◽  
Fathalla F. Belal ◽  
Shinya Kitagawa ◽  
Noritada Kaji ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Separation Efficiency ◽  
Background Electrolyte ◽  
Dosage Forms ◽  
Inclusion Complex Formation ◽  
Pharmaceutical Dosage Forms ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method ◽  
P Addition

Addition of β-cyclodextrin to the background electrolyte improves the separation efficiency of multi-component mixtures through inclusion complex formation.

Capillary Electrophoresis Method for Determination of Escitalopram Oxalate in Urine Samples and Different Dosage Forms

2020 ◽  
Vol 58 (8) ◽  
pp. 759-769
Author(s):  
Wafa F S Badulla ◽  
Arın G Dal Poçan ◽  
Zeki Atkoşar ◽  
Göksel Arlı
Keyword(s):  
Capillary Electrophoresis ◽  
Limit Of Detection ◽  
Background Electrolyte ◽  
Dosage Forms ◽  
Fused Silica ◽  
Urine Samples ◽  
Effective Length ◽  
Simple Liquid ◽  
Pharmaceutical Dosage Forms

Abstract Application of capillary electrophoresis (CE) has become a rapidly growing analytical technique for the estimation of drugs in pharmaceutical dosage forms and biological fluids. In this study, an effective and sensitive method was developed for the determination of escitalopram oxalate (ESC-OX) by CE with diode-array detection at 200 nm. The separation was achieved by a fused silica capillary with 40 cm effective length (48.5 cm total, 75 μm i.d.). The background electrolyte was composed of 15 mM phosphate buffer (pH 2.5). The applied potential was 22.5 kV, and the samples were injected at 50 mbar pressure for 10 s. Metoprolol was used as an internal standard (IS). The migration time under these optimum conditions was 6.51 ± 0.07 and 6.73 ± 0.08 min for ESC-OX and IS, respectively, with total run time 7 min. The method was validated for linearity, precision, accuracy, specificity and sensitivity. The limit of detection was calculated as 3.85 and 5.07 ng mL−1 for standard and urine samples, respectively. The developed method was employed successfully for the determination of ESC-OX in different pharmaceutical dosage forms and spiked human urine after simple liquid–liquid extraction with good recovery.

Spectrophotometric Determination of Alendronate Sodium by using Sodium-1,2-Naphthoquinone-4-Sulphonate

2012 ◽  
Vol 4 (4) ◽  
pp. 1563-1568
Author(s):  
Sagar Suman Panda ◽  
Ravi Kumar B V V ◽  
D Patanaik
Keyword(s):  
Spectrophotometric Method ◽  
Absorption Maximum ◽  
Dosage Form ◽  
Dosage Forms ◽  
Alendronate Sodium ◽  
Colored Complex ◽  
Pharmaceutical Dosage Forms ◽  
Recovery Study ◽  
Assay Conditions

A simple, precise and accurate spectrophotometric method was developed for analysis of the osteoporesis drug alendronate sodium (ALS). The method is based on reaction of the drug with sodium-1,2-naphthoquinone-4-sulphonate (NQS) in presence of alkali to form a brown colored complex giving absorption maximum at 525 nm. The drug obeyed Beer’s law in the range of 5-70 µg/ml with a correlation coefficient of 0.999. The LOD and LOQ values are 1.7 µg/ml and 5.0 µg/ml, respectively. The average recoveries for recovery study were found to be in the range of 99.37%-100.46%. The R.S.D. values for intraday and inter-day precision were found to be 0.48 and 0.62, respectively. The optimized assay conditions were applied successfully for determination of ALS in pharmaceutical dosage forms. No interference was observed from the excipients present in the dosage form. The method is statistically validated as per the ICH requirements.  

Electroanalytical Methods for Determination of Calcium Channel Blockers

2019 ◽  
Vol 15 (3) ◽  
pp. 207-218 ◽  
Author(s):  
Fatma Ağın
Keyword(s):  
Calcium Channel ◽  
Calcium Channel Blockers ◽  
Channel Blocker ◽  
Heart Diseases ◽  
Dosage Forms ◽  
Channel Blockers ◽  
Electroanalytical Methods ◽  
Pharmaceutical Dosage Forms ◽  
Ischemic Heart Diseases

Background:Calcium Channel Blockers (CCBs) are widely used in the treatment of cardiovascular and ischemic heart diseases in recent years. They treat arrhythmias by reducing cardiac cycle contraction and also benefit ischemic heart diseases. Electroanalytical methods are very powerful analytical methods used in the pharmaceutical industry because of the determination of therapeutic agents and/or their metabolites in clinical samples at extremely low concentrations (10-50 ng/ml). The purpose of this review is to gather electroanalytical methods used for the determination of calcium channel blocker drugs in pharmaceutical dosage forms and biological media selected mainly from current articles.Methods:This review mainly includes recent determination studies of calcium channel blockers by electroanalytical methods from pharmaceutical dosage forms and biological samples. The studies of calcium channel blockers electroanalytical determination in the literature were reviewed and interpreted.Results:There are a lot of studies on amlodipine and nifedipine, but the number of studies on benidipine, cilnidipine, felodipine, isradipine, lercanidipine, lacidipine, levamlodipine, manidipine, nicardipine, nilvadipine, nimodipine, nisoldipine, nitrendipine, diltiazem, and verapamil are limited in the literature. In these studies, DPV and SWV are the most used methods. The other methods were used less for the determination of calcium channel blocker drugs.Conclusion:Electroanalytical methods especially voltammetric methods supply reproducible and reliable results for the analysis of the analyte. These methods are simple, more sensitive, rapid and inexpensive compared to the usually used spectroscopic and chromatographic methods.

scholarly journals A new validated RP-HPLC method for the determination of Tinidazole and Roxithromycin in its bulk and pharmaceutical dosage forms

2020 ◽  
Author(s):  
N. M. D. Akram ◽  
N. Madana Gopal ◽  
A. Balakrishna ◽  
N. Bakthavatchala Reddy ◽  
Grigory V. Zyryanov
Keyword(s):  
Dosage Forms ◽  
Hplc Method ◽  
Pharmaceutical Dosage Forms ◽  
Rp Hplc

COLORIMETRIC DETERMINATION OF CRUDE POWDERED MYRRH, PURIFIED MYRRH EXTRACT, OILY FRACTION, AND ITS DIFFERENT PHARMACEUTICAL DOSAGE FORMS

2002 ◽  
Vol 35 (2) ◽  
pp. 183-197 ◽  
Author(s):  
Mohamed H. Abdel-Hay ◽  
Amal Saleh ◽  
E. S. H. El Ashry ◽  
N. Rashed ◽  
Osama Salama
Keyword(s):  
Dosage Forms ◽  
Colorimetric Determination ◽  
Pharmaceutical Dosage Forms
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