Determination of six anti-Parkinson drugs using cyclodextrin-capillary electrophoresis method: application to pharmaceutical dosage forms

RSC Advances ◽  
2016 ◽  
Vol 6 (21) ◽  
pp. 17519-17530 ◽  
Author(s):  
Abdallah M. Zeid ◽  
Jenny Jeehan M. Nasr ◽  
Fathalla F. Belal ◽  
Shinya Kitagawa ◽  
Noritada Kaji ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Separation Efficiency ◽  
Background Electrolyte ◽  
Dosage Forms ◽  
Inclusion Complex Formation ◽  
Pharmaceutical Dosage Forms ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method ◽  
P Addition

Addition of β-cyclodextrin to the background electrolyte improves the separation efficiency of multi-component mixtures through inclusion complex formation.

Capillary Electrophoresis Method for Determination of Escitalopram Oxalate in Urine Samples and Different Dosage Forms

2020 ◽  
Vol 58 (8) ◽  
pp. 759-769
Author(s):  
Wafa F S Badulla ◽  
Arın G Dal Poçan ◽  
Zeki Atkoşar ◽  
Göksel Arlı
Keyword(s):  
Capillary Electrophoresis ◽  
Limit Of Detection ◽  
Background Electrolyte ◽  
Dosage Forms ◽  
Fused Silica ◽  
Urine Samples ◽  
Effective Length ◽  
Simple Liquid ◽  
Pharmaceutical Dosage Forms

Abstract Application of capillary electrophoresis (CE) has become a rapidly growing analytical technique for the estimation of drugs in pharmaceutical dosage forms and biological fluids. In this study, an effective and sensitive method was developed for the determination of escitalopram oxalate (ESC-OX) by CE with diode-array detection at 200 nm. The separation was achieved by a fused silica capillary with 40 cm effective length (48.5 cm total, 75 μm i.d.). The background electrolyte was composed of 15 mM phosphate buffer (pH 2.5). The applied potential was 22.5 kV, and the samples were injected at 50 mbar pressure for 10 s. Metoprolol was used as an internal standard (IS). The migration time under these optimum conditions was 6.51 ± 0.07 and 6.73 ± 0.08 min for ESC-OX and IS, respectively, with total run time 7 min. The method was validated for linearity, precision, accuracy, specificity and sensitivity. The limit of detection was calculated as 3.85 and 5.07 ng mL−1 for standard and urine samples, respectively. The developed method was employed successfully for the determination of ESC-OX in different pharmaceutical dosage forms and spiked human urine after simple liquid–liquid extraction with good recovery.

scholarly journals Development of a fast capillary electrophoresis method for determination of carbohydrates in honey samples

Talanta ◽  
2012 ◽  
Vol 93 ◽  
pp. 62-66 ◽  
Author(s):  
Viviane Maria Rizelio ◽  
Laura Tenfen ◽  
Roberta da Silveira ◽  
Luciano Valdemiro Gonzaga ◽  
Ana Carolina Oliveira Costa ◽  
...  
Keyword(s):  
Capillary Electrophoresis ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method

A novel nonaqueous capillary electrophoresis method for effective separation and simultaneous determination of aurantio-obtusin, emodin and rhein in semen cassiae and cassia seed tea

2014 ◽  
Vol 6 (14) ◽  
pp. 5133-5139 ◽  
Author(s):  
Ning Wang ◽  
Yuanyuan Wu ◽  
Xingqiang Wu ◽  
Shuxuan Liang ◽  
Hanwen Sun
Keyword(s):  
Capillary Electrophoresis ◽  
Simultaneous Determination ◽  
Uv Detection ◽  
Nonaqueous Capillary Electrophoresis ◽  
Effective Separation ◽  
Capillary Electrophoresis Method ◽  
Electrophoresis Method ◽  
Novel Method

A novel method using nonaqueous capillary electrophoresis-UV detection was used for the effective separation and rapid simultaneous determination of anthraquinones, aurantio-obtusin, emodin and rhein, in semen cassiae and cassia seed tea.

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