scholarly journals Polymorphism of the ADRB2 gene as a factor of hereditary susceptibility to the development of asthma and response to salbutamol therapy

2019 ◽  
pp. 38-45
Author(s):  
L.A. Livshits ◽  
◽  
P.F. Tatarsky ◽  
O.V. Gorodna ◽  
A.V. Mayakovskaya ◽  
...  
Keyword(s):  
Adrb2 Gene ◽  
Hereditary Susceptibility

scholarly journals Heterozygote polymorphisms of ARG16GLY and GLN27GLU ADRB2 gene is risk protective for obesity in Javanese population of Indonesia

2018 ◽  
Vol 17 (37) ◽  
pp. 1172-1179
Author(s):  
Rahma Shafriani Nazula ◽  
Hastuti Pramudji ◽  
Hamim Sadewa Ahmad
Keyword(s):  
Adrb2 Gene

Hereditary Susceptibility for Triple Negative Breast Cancer Associated With Western Sub-Saharan African Ancestry

2019 ◽  
Vol 270 (3) ◽  
pp. 484-492 ◽  
Author(s):  
Lisa A. Newman ◽  
Brittany Jenkins ◽  
Yalei Chen ◽  
Joseph K. Oppong ◽  
Ernest Adjei ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Triple Negative Breast Cancer ◽  
Triple Negative ◽  
African Ancestry ◽  
Sub Saharan ◽  
Hereditary Susceptibility

scholarly journals TV watching modifies obesity risk linked to the 27Glu polymorphism of the ADRB2 gene in girls

2006 ◽  
Vol 1 (2) ◽  
pp. 83-88 ◽  
Author(s):  
M. C. Ochoa ◽  
M. J. Moreno-Aliaga ◽  
M. A. Martínez-González ◽  
J. A. Martínez ◽  
A. Marti ◽  
...  
Keyword(s):  
Obesity Risk ◽  
Adrb2 Gene ◽  
Tv Watching

scholarly journals Association of FTO and ADRB2 gene variation with energy restriction induced adaptations in resting energy expenditure and physical activity

Gene X ◽  
2019 ◽  
Vol 3 ◽  
pp. 100019
Author(s):  
Stefan G.J.A. Camps ◽  
Sanne P.M. Verhoef ◽  
Freek G. Bouwman ◽  
Edwin C.M. Mariman ◽  
Klaas R. Westerterp
Keyword(s):  
Physical Activity ◽  
Energy Expenditure ◽  
Resting Energy Expenditure ◽  
Energy Restriction ◽  
Gene Variation ◽  
Adrb2 Gene ◽  
Resting Energy

Genetic Polymorphisms in the Promoter Region of the beta-2 Adrenergic Receptor Are Associated with the Early Response of Acute Lymphoblastic Leukemia to Chemotherapy.

Blood ◽  
2004 ◽  
Vol 104 (11) ◽  
pp. 1959-1959
Author(s):  
Meyling H. Cheok ◽  
Cong Ding ◽  
Wenjian Yang ◽  
Somas Das ◽  
Dario Campana ◽  
...  
Keyword(s):  
Gene Expression ◽  
Acute Lymphoblastic Leukemia ◽  
Adrenergic Receptor ◽  
Lymphoblastic Leukemia ◽  
Receptor Gene ◽  
High Dose ◽  
A Genome ◽  
Adrb2 Gene ◽  
Beta 2

Abstract Acute lymphoblastic leukemia (ALL) in children is a paradigm of disseminated cancer that is curable with chemotherapy, yet current treatment fails to cure about 20% of patients, for reasons that remain unknown. In a genome-wide assessment of in vivo treatment-induced changes in gene expression in ALL cells using the Affymetrix U95A and U133A oligonucleotide microarray, we found that patients who eventually relapsed did not up-regulate expression of the pro-apoptotic beta-2 adrenergic receptor gene (ADRB2) in their ALL cells after initial treatment with methotrexate and mercaptopurine. After treatment we observed a 5-fold lower level of ADRB2 gene expression in leukemia cells of patients who ultimately relapsed. We found a common genetic polymorphism in the ADRB2 promoter that was significantly linked to high-dose methotrexate induced up-regulation in ADRB2 gene expression in ALL cells. Moreover, the ADRB2 promoter haplotype was significantly linked to poor early treatment response in ALL cells from 242 children (i.e., probability of event-free survival at two years, p=0.0275 stratified by risk groups). These findings have revealed a germline polymorphism that is linked to the early antileukemic effects of ALL chemotherapy and provide new insights into genetic determinants of ALL treatment efficacy.

370 - Genetic Variation Within GNβ3 and ADRB2 Gene Systems are Associated with Higher Symptom Burden and Perceptive Esophageal Symptoms

2018 ◽  
Vol 154 (6) ◽  
pp. S-86-S-87
Author(s):  
Stephen Hasak ◽  
Amit Patel ◽  
Billy D. Nix ◽  
Gregory S. Sayuk ◽  
Rodney D. Newberry ◽  
...  
Keyword(s):  
Genetic Variation ◽  
Symptom Burden ◽  
Adrb2 Gene

scholarly journals THE ANALYSIS OF THE ASSOCIATION OF ADRB2 GENE POLYMORPHISM AND EXTERNAL RESPIRATORY FUNCTION IN CHILDREN WITH BRONCHIAL ASTHMA

2021 ◽  
Vol 20 (2) ◽  
pp. 71-76
Author(s):  
E.S. Minina ◽  
◽  
V.I. Novikova ◽  
P.D. Novikov ◽  
A.S. Babenka ◽  
...  
Keyword(s):  
Gene Polymorphism ◽  
Asthma Control ◽  
Bronchial Asthma ◽  
Respiratory Function ◽  
Gene Locus ◽  
Subjective Assessment ◽  
Control Test ◽  
Asthma Control Test ◽  
Individual Program ◽  
Adrb2 Gene

Objectives. To study the role of the ADRB2 gene polymorphism (rs1042713) in the impaired external respiratory function in children with bronchial asthma (BA). Material and methods. The study group included 60 children aged 3-17 years with allergic (n=37) and mixed form of BA (n=23). The genotyping of the investigated gene locus was performed by PCR-RFLP (polymerase chain reaction - restriction fragment length polymorphism), BA control was exercised using the Asthma Control Test (ACT). Results. The analysis of allele frequencies showed an association of allele A with normal spirogram parameters in patients with BA (p=0.042). In children under 12 years, there were statistically significant differences in spirogram indices when comparing patients with genotypes AA and GG (p=0.045). An association of allele A with the absence of pathological changes was revealed when evaluating the results of spirometry (p=0.021). There was a moderate positive correlation (r=0.615, p=0.011) between the assessment of nocturnal symptoms (Asthma Control Test) and the genotype of the ADRB2 gene polymorphism in children aged 12 years and older. Conclusions. An association of the ADRΒ2 gene polymorphism (rs1042713) with the external respiratory function was revealed in an objective study by spirometry and a subjective assessment of this indicator by the patient himself/herself or by his/her parents. This gene locus can be included in the BA target panel in order to determine the likelihood of uncontrolled course development of the disease with impaired external respiratory function and in the future to develop an individual program for dispensary observation of the patient.

scholarly journals Exome sequencing identifies a recurrent variant in SERPINA3 associating with hereditary susceptibility to breast cancer

2021 ◽  
Vol 143 ◽  
pp. 46-51
Author(s):  
Susanna Koivuluoma ◽  
Anna Tervasmäki ◽  
Saila Kauppila ◽  
Robert Winqvist ◽  
Timo Kumpula ◽  
...  
Keyword(s):  
Breast Cancer ◽  
Exome Sequencing ◽  
Hereditary Susceptibility
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