Carbonate Apatite-Bearing Pure Titanium Implant

1999 ◽  
Vol 599 ◽  
Author(s):  
K. Teraoka ◽  
T. Nonami ◽  
H. Taoda ◽  
K. Naganuma ◽  
Y. Yokogawa ◽  
...  
Keyword(s):  
Bone Formation ◽  
Pure Titanium ◽  
Titanium Implant ◽  
Carbonate Apatite ◽  
New Bone Formation

AbstractNew bone formation around implants is one of preferable conditions for the successful implantation. In this study, formable carbonate apatite ceramics were prepared and implanted in cavities (φ 400 μm, depth 400 μm) on the surface of pure titanium implant (ASTMB348-GR2) to enhance new bone formation around the titanium implant.

scholarly journals Physical and Histological Comparison of Hydroxyapatite, Carbonate Apatite, and β-Tricalcium Phosphate Bone Substitutes

Materials ◽  
2018 ◽  
Vol 11 (10) ◽  
pp. 1993 ◽  
Author(s):  
Kunio Ishikawa ◽  
Youji Miyamoto ◽  
Akira Tsuchiya ◽  
Koichiro Hayashi ◽  
Kanji Tsuru ◽  
...  
Keyword(s):  
Bone Formation ◽  
Bone Defect ◽  
Tricalcium Phosphate ◽  
Bone Substitutes ◽  
Physiological Solution ◽  
Tissue Response ◽  
Histological Evaluation ◽  
Carbonate Apatite ◽  
Artificial Bone ◽  
New Bone Formation

Three commercially available artificial bone substitutes with different compositions, hydroxyapatite (HAp; Neobone®), carbonate apatite (CO3Ap; Cytrans®), and β-tricalcium phosphate (β-TCP; Cerasorb®), were compared with respect to their physical properties and tissue response to bone, using hybrid dogs. Both Neobone® (HAp) and Cerasorb® (β-TCP) were porous, whereas Cytrans® (CO3Ap) was dense. Crystallite size and specific surface area (SSA) of Neobone® (HAp), Cytrans® (CO3Ap), and Cerasorb® (β-TCP) were 75.4 ± 0.9 nm, 30.8 ± 0.8 nm, and 78.5 ± 7.5 nm, and 0.06 m2/g, 18.2 m2/g, and 1.0 m2/g, respectively. These values are consistent with the fact that both Neobone® (HAp) and Cerasorb® (β-TCP) are sintered ceramics, whereas Cytrans® (CO3Ap) is fabricated in aqueous solution. Dissolution in pH 5.3 solution mimicking Howship’s lacunae was fastest in CO3Ap (Cytrans®), whereas dissolution in pH 7.3 physiological solution was fastest in β-TCP (Cerasorb®). These results indicated that CO3Ap is stable under physiological conditions and is resorbed at Howship’s lacunae. Histological evaluation using hybrid dog mandible bone defect model revealed that new bone was formed from existing bone to the center of the bone defect when reconstructed with CO3Ap (Cytrans®) at week 4. The amount of bone increased at week 12, and resorption of the CO3Ap (Cytrans®) was confirmed. β-TCP (Cerasorb®) showed limited bone formation at week 4. However, a larger amount of bone was observed at week 12. Among these three bone substitutes, CO3Ap (Cytrans®) demonstrated the highest level of new bone formation. These results indicate the possibility that bone substitutes with compositions similar to that of bone may have properties similar to those of bone.

scholarly journals Osseointegration of Maxillary Dental Implants in Diabetes Mellitus Patients: A Randomized Clinical Trial Human Histomorphometric Study

2020 ◽  
Vol 10 (19) ◽  
pp. 6762
Author(s):  
Lyly Sam ◽  
Siriporn Chattipakorn ◽  
Pathawee Khongkhunthian
Keyword(s):  
Type 2 Diabetes ◽  
Bone Formation ◽  
Dental Implants ◽  
Pearson Correlation ◽  
Titanium Implant ◽  
Control Group ◽  
Healthy Controls ◽  
New Bone Formation ◽  
Implant Surface

Background: Survival of dental implants in well-controlled Type 2 diabetes (T2DM) was found to be comparable to that in healthy patients. However, to our best knowledge, there have been no studies of the bone histomorphometry of osseointegration in patients with Type 2 diabetes. Purpose: To compare bone-implant-contact (BIC) and new bone formation between well-controlled Type 2 diabetes with HbA1c of less than 8% and healthy controls. Methods: 10 diabetic (T2DM) patients and 10 healthy controls were selected. Each patient received a 2.5 mm × 5 mm micro-implant in the maxilla, in either the premolar or first molar area. After 8 weeks of healing, the micro-implant was retrieved using a trephine bur and sent for bone histomorphometric analysis. A commercial titanium implant was immediately placed as the conventional treatment. Results: The mean BIC (30.73%) in T2DM patients was significantly lower than in the healthy patients (41.75%) (p = 0.01). New bone formation around the implant surface was reduced in T2DM patients (36.25%) compared to that in the control group (44.14%) (p = 0.028). The Pearson correlation coefficient revealed a strong correlation between increased HbA1c and decreased BIC (p < 0.05) and decreased new bone formation (p < 0.05). Conclusions: Within the limitation of this study, bone-to-implant contact and bone healing around dental implants in T2DM patients were significantly lower than in healthy patients.

Bone particles disturb new bone formation on the interface of the titanium implant after reaming of the marrow cavity

Bone ◽  
1996 ◽  
Vol 19 (6) ◽  
pp. 589-594 ◽  
Author(s):  
M. Ishizaka ◽  
T. Tanizawa ◽  
M. Sofue ◽  
Y. Dohmae ◽  
N. Endo ◽  
...  
Keyword(s):  
Bone Formation ◽  
Titanium Implant ◽  
New Bone Formation ◽  
Marrow Cavity ◽  
Bone Particles

Effect of the surface treatment and hole size of pure titanium mesh on new bone formation

2019 ◽  
Vol 8 (1) ◽  
pp. 6-13 ◽  
Author(s):  
Hong-Bing Shi ◽  
Yong-Seok Jang ◽  
Thuy-Duong Thi Nguyen ◽  
Tae-Ju Oh ◽  
A-Lum Han ◽  
...  
Keyword(s):  
Bone Formation ◽  
Surface Treatment ◽  
Pure Titanium ◽  
Hole Size ◽  
Titanium Mesh ◽  
New Bone Formation

scholarly journals Histomorphometric analysis of pure titanium implants with porous surface versus rough surface

2006 ◽  
Vol 14 (3) ◽  
pp. 213-218 ◽  
Author(s):  
Aline Scalone Brentel ◽  
Luana Marotta Reis de Vasconcellos ◽  
Marize Varella Oliveira ◽  
Mário Lima de Alencastro Graça ◽  
Luis Gustavo Oliveira de Vasconcellos ◽  
...  
Keyword(s):  
Bone Formation ◽  
Rough Surface ◽  
Bone Repair ◽  
Pure Titanium ◽  
Titanium Implants ◽  
Porous Surface ◽  
Histomorphometric Analysis ◽  
New Bone Formation ◽  
Bone Interface ◽  
Significant Difference

The purpose of this study was to analyze the bone repair around commercially pure titanium implants with rough and porous surface, fabricated using powder metallurgy technique, after their insertion in tibiae of rabbits. Seven male rabbits were used. Each animal received 3 porous-surface implants in the left tibia and 3 rough-surface implants in the right tibia. The rabbits were sacrificed 4 weeks after surgery and fragments of the tibiae containing the implants were submitted to histological and histomorphometric analyses to evaluate new bone formation at the implant-bone interface. Means (%) of bone neoformation obtained in the histomorphometric analysis were compared by Student's t-test for paired samples at 5% significance level.. The results of the histological analysis showed that osseointegration occurred for both types of implants with similar quality of bone tissue. The histomorphometric analysis revealed means of new bone formation at implant-bone interface of 79.69 ± 1.00% and 65.05 ± 1.23% for the porous- and rough-surface implants, respectively. Statistically significant difference was observed between the two types of implants with respect to the amount new bone formation (p<0.05). In conclusion, the porous-surface implants contributed to the osseointegration because they provide a larger contact area at implant-bone interface.

scholarly journals Effect of rhBMP-2 applied with a 3D-printed titanium implant on new bone formation in rabbit calvarium

2021 ◽  
Vol 29 ◽  
Author(s):  
RYU Jaeyoung ◽  
Hyo-Sun KANG ◽  
Byung-Hun KANG ◽  
Seunggon JUNG ◽  
Min-Suk KOOK ◽  
...  
Keyword(s):  
Bone Formation ◽  
Titanium Implant ◽  
New Bone Formation ◽  
3D Printed

Histological and Histomorphometric Studies of the Effects of Hyaluronic Acid on Osseointegration of Titanium Implant in Rabbits

2018 ◽  
Vol 30 (2) ◽  
pp. 10-16
Author(s):  
Mohammad Hasan Mohammad ◽  
Nada M. H. Al-Ghaban
Keyword(s):  
Hyaluronic Acid ◽  
Bone Formation ◽  
Healing Process ◽  
Pure Titanium ◽  
Titanium Implant ◽  
Commercially Pure Titanium ◽  
Histomorphometric Analysis ◽  
Natural Polymers ◽  
Commercially Pure ◽  
Significant Difference

Background: One of the unique prosthesis for tooth or teeth replacement is the dental implant. Our attempt is using a biomaterial system that is easily obtained and applicable and has the ability to provoke osteoinductive growth factor to enhance bone formation at the site of application. One of these natural polymers is hyaluronic acid. Material and methods: Sixty machined surface implants from commercially pure titanium rod inserted in thirty NewZealand rabbits. Two implants placed in both tibia of each rabbit. The animals scarified at 1, 2 and 4 weeks after implantation (10 rabbits for each interval). For all of animals the right tibia’s implant was control (uncoated) and the left one was experimental (coated with 0.1ml Hyaluronic acid gel). All sections have been stained with Haematoxylin and Eosin then they were histologically examined and assessed for histomorphometric analysis for counting of bone cells (osteoblast, osteocyte and osteoclast), cortical bone thickness, trabecular width, thread width and marrow space star volume (V*). Results: Histological findings for hyaluronic acid- coated titanium implant revealed an earlier bone formation, mineralization and maturation than that in control groups. Histomorphometric analysis for all bone parameters that examined in this study, showed highly significant difference between control and experimental groups in all healing intervals. Conclusion: Commercially pure titanium endosseous implants coated with hyaluronic acid may be osteocoductive thus accelerating healing process and enhancing osseointegration.

scholarly journals Osteoblast maturation and new bone formation in response to titanium implant surface features are reduced with age

2012 ◽  
Vol 27 (8) ◽  
pp. 1773-1783 ◽  
Author(s):  
Rene Olivares-Navarrete ◽  
Andrew L Raines ◽  
Sharon L Hyzy ◽  
Jung Hwa Park ◽  
Daphne L Hutton ◽  
...  
Keyword(s):  
Bone Formation ◽  
Titanium Implant ◽  
New Bone Formation ◽  
Implant Surface ◽  
Surface Features ◽  
Osteoblast Maturation ◽  
Titanium Implant Surface
Sign in / Sign up

Export Citation Format

Share Document