Resorbable Synthetic Bone Grafts Formed From a Silicon Stabilized Calcium Phosphate Bioceramic

1998 ◽  
Vol 550 ◽  
Author(s):  
S. Langstaff ◽  
M. Sayer ◽  
T. Smith ◽  
S. Pugh
Keyword(s):  
Calcium Phosphate ◽  
Chemical Reactivity ◽  
Calcium Hydroxyapatite ◽  
Bone Grafts ◽  
Ceramic Coatings ◽  
Substitution Reactions ◽  
Synthetic Bone ◽  
Characteristic Features ◽  
Synthetic Bone Grafts

AbstractSynthetic bone grafts resistant to random dissolution at physiological pH, yet capable of being gradually resorbed in vitro by osteoclasts have been created. Bulk ceramics and ceramic coatings formed from an additive stabilized colloidal sol possess two characteristic features: a phase mixture of calcium hydroxyapatite (HA) and a silicon stabilized tricalcium phosphate, and a microporous morphology based on inter-connected particles (0.2-1.0 μm). The characteristic phase composition arises during sintering through substitution reactions where silicon enters the calcium phosphate lattice under conditions of high chemical reactivity. Evidence for in vitro resorption lacunae on bulk ceramics is presented.

Long-term radiographic appearance of calcium-phosphate synthetic bone grafts after surgical treatment of tibial plateau fractures

Injury ◽  
2017 ◽  
Vol 48 (12) ◽  
pp. 2807-2813 ◽  
Author(s):  
Alexander Hanke ◽  
Martin Bäumlein ◽  
Siegmund Lang ◽  
Boyko Gueorguiev ◽  
Michael Nerlich ◽  
...  
Keyword(s):  
Surgical Treatment ◽  
Calcium Phosphate ◽  
Tibial Plateau ◽  
Bone Grafts ◽  
Tibial Plateau Fractures ◽  
Radiographic Appearance ◽  
Synthetic Bone ◽  
Synthetic Bone Grafts

Implications of unconventional setting conditions on the mechanical strength of synthetic bone grafts produced with self-hardening calcium phosphate pastes

2021 ◽  
Author(s):  
Adelia Kashimbetova ◽  
Karel Slámečka ◽  
Mariano Casas-Luna ◽  
Carolina Oliver-Urrutia ◽  
Simona Ravaszová ◽  
...  
Keyword(s):  
Calcium Phosphate ◽  
Mechanical Strength ◽  
Bone Grafts ◽  
Synthetic Bone ◽  
Synthetic Bone Grafts

scholarly journals Thin Degradable Coatings for Optimization of Osteointegration Associated with Simultaneous Infection Prophylaxis

Materials ◽  
2019 ◽  
Vol 12 (21) ◽  
pp. 3495 ◽  
Author(s):  
Sophie Burtscher ◽  
Peter Krieg ◽  
Andreas Killinger ◽  
Ali Al-Ahmad ◽  
Michael Seidenstücker ◽  
...  
Keyword(s):  
Phase Composition ◽  
Calcium Phosphate ◽  
Release Kinetics ◽  
Titanium Substrate ◽  
Ceramic Coatings ◽  
Microbial Colonization ◽  
Flame Spraying ◽  
Infection Prophylaxis ◽  
Aseptic Prosthesis Loosening

One of the most common causes of implant failure is aseptic prosthesis loosening. Another frequent complication after prosthesis implant is the microbial colonization of the prosthesis surface, which often leads to a replacement of the prosthesis. One approach to reduce these complications is the application of bioactive substances to implant surfaces. Both an antibiotic prophylaxis and a faster osteointegration can be obtained by incorporation of bactericidal active metals in degradable calcium phosphate (CaP) coatings. In this study, thin degradable calcium phosphate ceramic coatings doped with silver (Ag), copper (Cu), and bismuth (Bi) on a titanium substrate were prepared with the aid of the high-velocity suspension flame spraying (HVSFS) coating process. To characterize the samples surface roughness, brightfield microscopy of the coatings, X-ray diffraction (XRD)-analysis for definition of the phase composition of the layers, Raman spectroscopy for determination of the phase composition of the contained metals, element-mapping for Cu-content verification, release kinetics for detection of metal ions and ceramic components of the coatings were carried out. The aim of this study was to evaluate in vitro biocompatibility and antimicrobial activity of the coatings. For biocompatibility testing, growth experiments were performed using the cell culture line MG-63. Cell viability was investigated by Giemsa staining and live/dead assay. The WST-1 kit was used to quantify cell proliferation and vitality in vitro and the lactate dehydrogenase (LDH) kit to quantify cytotoxicity. The formation of hydroxyapatite crystals in simulated body fluid was investigated to predict bioactivity in vivo. The Safe Airborne Antibacterial Assay with Staphylococcus aureus (S. aureus) was used for antimicrobial testing. The results showed good biocompatibility of all the metal doped CaP coatings, furthermore Cu and Ag doped layers showed significant antibacterial effects against S. aureus.

scholarly journals A giant periosteal chondroma of the distal femur successfully reconstructed with synthetic bone grafts and a bioresorbable plate: a case report

2014 ◽  
Vol 12 (1) ◽  
pp. 354 ◽  
Author(s):  
Yoshinori Imura ◽  
Atsuo Shigi ◽  
Hidetatsu Outani ◽  
Kenichiro Hamada ◽  
Hiromi Tamura ◽  
...  
Keyword(s):  
Case Report ◽  
Distal Femur ◽  
Bone Grafts ◽  
Synthetic Bone ◽  
Periosteal Chondroma ◽  
Bioresorbable Plate ◽  
Synthetic Bone Grafts
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