Development of a Simple and Highly Sensitive Microbalance for Measurements of Total Particle Yields in Matrix Assisted Laser Desorption

1992 ◽  
Vol 285 ◽  
Author(s):  
T. Huth-fehre ◽  
A.P. Quist ◽  
S-O. Linder ◽  
B.U.R. Sundqvist
Keyword(s):  
Quartz Crystal ◽  
Laser Desorption ◽  
Laser Desorption Ionization ◽  
Neutral Particles ◽  
Highly Sensitive ◽  
The Matrix ◽  
Total Particle ◽  
Insight Into ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

ABSTRACTIn order to open a new window for getting insight into the process of matrix assisted laser desorption ionization (MALDI) of biopolymers, a highly sensitive quartz crystal microbalance (QCM) was developed to measure desorption yields of neutral particles. For the matrix substances commonly used the mass resolution of 0.95 ng obtained with the balance corresponds to a detection limit of ∼1012 particles.

scholarly journals Cyanocobalamin conjugates of cisplatin and diaminocyclohexane-platinum(ii): matrix-assisted laser desorption ionization mass spectrometry characterization using 4-chloro-α-cyanocinnamic acid as the matrix

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 53658-53666 ◽  
Author(s):  
G. Ventura ◽  
F. Arnesano ◽  
C. D. Calvano ◽  
F. Palmisano ◽  
T. R. I. Cataldi
Keyword(s):  
Mass Spectrometry ◽  
Chemotherapeutic Agent ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Malignant Tumours ◽  
Desorption Ionization ◽  
The Matrix ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

cis-Diamminedichloroplatinum(ii), also known as cisplatin, is a widely used chemotherapeutic agent to treat several malignant tumours, but unfortunately it causes serious side effects, especially nausea, vomiting and nephrotoxicity.

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