Improving the analyte ion signal in matrix-assisted laser desorption/ionization imaging mass spectrometry via electrospray deposition by enhancing incorporation of the analyte in the matrix

2017 ◽  
Vol 31 (9) ◽  
pp. 804-812 ◽  
Author(s):  
Brian J. Malys ◽  
Kevin G. Owens
Keyword(s):  
Mass Spectrometry ◽  
Imaging Mass Spectrometry ◽  
Laser Desorption ◽  
Laser Desorption Ionization ◽  
Electrospray Deposition ◽  
Desorption Ionization ◽  
The Matrix ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

scholarly journals Cyanocobalamin conjugates of cisplatin and diaminocyclohexane-platinum(ii): matrix-assisted laser desorption ionization mass spectrometry characterization using 4-chloro-α-cyanocinnamic acid as the matrix

RSC Advances ◽  
2017 ◽  
Vol 7 (85) ◽  
pp. 53658-53666 ◽  
Author(s):  
G. Ventura ◽  
F. Arnesano ◽  
C. D. Calvano ◽  
F. Palmisano ◽  
T. R. I. Cataldi
Keyword(s):  
Mass Spectrometry ◽  
Chemotherapeutic Agent ◽  
Laser Desorption ◽  
Ionization Mass ◽  
Laser Desorption Ionization ◽  
Malignant Tumours ◽  
Desorption Ionization ◽  
The Matrix ◽  
Matrix Assisted Laser ◽  
Matrix Assisted Laser Desorption

cis-Diamminedichloroplatinum(ii), also known as cisplatin, is a widely used chemotherapeutic agent to treat several malignant tumours, but unfortunately it causes serious side effects, especially nausea, vomiting and nephrotoxicity.

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