scholarly journals Bio Focus: 3D-printed octacalcium phosphate bone substitutes reduce defect region

MRS Bulletin ◽  
2015 ◽  
Vol 40 (9) ◽  
pp. 712-713 ◽  
Author(s):  
Yung Chan
Keyword(s):  
Bone Substitutes ◽  
Octacalcium Phosphate ◽  
Defect Region ◽  
3D Printed

Bioresorption and biodegradation of the 3D-printed gene-activated bone substitutes based on octacalcium phosphate

2020 ◽  
Vol XV (1) ◽  
Author(s):  
E. Presnyakov ◽  
I. Bozo ◽  
I. Smirnov ◽  
V. Komlev ◽  
V. Popov ◽  
...  
Keyword(s):  
Bone Substitutes ◽  
Octacalcium Phosphate ◽  
3D Printed

scholarly journals 3D Printed Gene-activated Octacalcium Phosphate Implants for Large Bone Defects Engineering

2020 ◽  
Vol 6 (3) ◽  
Author(s):  
Ilya I Bozo ◽  
Roman V. Deev ◽  
Igor V. Smirnov ◽  
Alexander Yu Fedotov ◽  
Vladimir K. Popov ◽  
...  
Keyword(s):  
Plasmid Dna ◽  
Three Dimensional ◽  
Bone Substitutes ◽  
Octacalcium Phosphate ◽  
Dna Encoding ◽  
X Ray Diffraction ◽  
3D Printed ◽  
Clinical Potential ◽  
Large Bone

The aim of the study was the development of three-dimensional (3D) printed gene-activated implants based on octacalcium phosphate (OCP) and plasmid DNA encoding VEGFA. The first objective of the present work involved design and fabrication of gene-activated bone substitutes based on the OCP and plasmid DNA with VEGFА gene using 3D printing approach of ceramic constructs, providing the control of its architectonics compliance to the initial digital models. X-ray diffraction, scanning electron microscopy (SEM), Fourier transform infrared spectroscopy, and compressive strength analyses were applied to investigate the chemical composition, microstructure, and mechanical properties of the experimental samples. The biodegradation rate and the efficacy of plasmid DNA delivery in vivo were assessed during standard tests with subcutaneous implantation to rodents in the next stage. The final part of the study involved substitution of segmental tibia and mandibular defects in adult pigs with 3D printed gene-activated implants. Biodegradation, osteointegration, and effectiveness of a reparative osteogenesis were evaluated with computerized tomography, SEM, and a histological examination. The combination of gene therapy and 3D printed implants manifested the significant clinical potential for effective bone regeneration in large/critical size defect cases.

Octacalcium phosphate coating for 3D printed cranioplastic porous titanium implants

2020 ◽  
Vol 383 ◽  
pp. 125192 ◽  
Author(s):  
Igor V. Smirnov ◽  
Roman V. Deev ◽  
Ilya I. Bozo ◽  
Alexander Yu. Fedotov ◽  
Alex N. Gurin ◽  
...  
Keyword(s):  
Octacalcium Phosphate ◽  
Porous Titanium ◽  
Titanium Implants ◽  
Phosphate Coating ◽  
3D Printed

scholarly journals 3D Printing of Octacalcium Phosphate Bone Substitutes

2015 ◽  
Vol 3 ◽  
Author(s):  
Vladimir S. Komlev ◽  
Vladimir K. Popov ◽  
Anton V. Mironov ◽  
Alexander Yu. Fedotov ◽  
Anastasia Yu. Teterina ◽  
...  
Keyword(s):  
3D Printing ◽  
Bone Substitutes ◽  
Octacalcium Phosphate

scholarly journals MECHANICAL PROPERTIES OF 3D SCAFFOLDS FOR BONE REGENERATION / 3D KARKASŲ, SKIRTŲ KAULŲ REGENERACIJAI, MECHANINIŲ SAVYBIŲ TYRIMAS

2017 ◽  
Vol 8 (6) ◽  
pp. 587-591
Author(s):  
Deividas Mizeras ◽  
Andžela Šešok ◽  
Algirdas Vaclovas Valiulis ◽  
Justinas Gargasas ◽  
Irmantas Gedzevičius
Keyword(s):  
Mechanical Properties ◽  
Testing Machine ◽  
Bone Substitutes ◽  
Point Of View ◽  
Bone Tissue Regeneration ◽  
3D Scaffolds ◽  
Bending Tests ◽  
Ethical Point ◽  
Additional Surgery ◽  
3D Printed

One of the biggest challenges in modern tissue engineering is a creation 3D scaffolds for bone tissue regeneration. Until now, in order to restore bone defects are used various bone substitutes (autologous and allogeneic), however, their usage is limited because is required additional surgery, possible complications, also limited their use is associated with ethical point of view. In this work we aim to determine the mechanical properties of 3D printed PLA objects having various orientation woodpile microarchitectures. In this work we chose three different 3D microarchitectures: woodpile BCC (each layer consists of parallel logs which are rotated 90 deg every next layer), woodpile FCC (every layer is additionally shifted half of the period in respect to the previous parallel log layer) and a rotating woodpile 60 deg (each layer is rotated 60 deg in respect to the previous one). Compressive and bending tests were carried out with TIRAtest2300 universal testing machine. We found that 60 deg rotating woodpile geometry had the highest mechanical values which were approximately about 3 times higher than the BCC or FCC microstructures. Vienas didžiausių šiuolaikinės audinių inžinerijos iššūkių yra 3D karkasų, skirtų kaulinio audinio regeneracijai, sukūrimas. Iki šiol, norint atstatyti kaulo defektus, naudojami įvairūs kaulo pakaitalai (autogeniniai ir alogeniniai), kurių naudojimo galimybės jau nebeatitinka poreikių, nes reikalinga papildoma operacija, galimos komplikacijos, taip pat ribotas jų naudojimas, susijęs su etinėmis pažiūromis. Šiame darbe lyginamos 3D spausdintuvu suformuotų mikrodarinių, skirtų kaulinio audinio defektui atkurti, mechaninės savybės. Darbe pasirinktos trys skirtingos 3D karkasų mikrostruktūros: woodpile BCC (kiekvienas sluoksnis susideda iš lygiagrečių rąstų, kurie keičiami 90 laipsnių kampu prieš tai esančio sluoksnio atžvilgiu), woodpile FCC (kiekvienas sluoksnis papildomai keičiasi per pusę periodo sluoksnio, esančio prieš tai, atžvilgiu) ir woodpile 60 deg (besisukanti rąstų rietuvė, kiekvienas tokios gardelės sluoksnis yra pasuktas 60 laipsnių prieš tai esančios atžvilgiu). Gniuždymo ir lenkimo bandymai buvo atlikti TIRAtest 2300 universalia bandymų mašina. Buvo nustatyta, kad, taikant 60 laipsnių kampu besikeičiančią woodpile geometriją, galima pasiekti didžiausias mechanines vertes, kurios buvo maždaug tris kartus didesnės nei woodfile BCC arba woodfile FCCmikrostruktūros.

scholarly journals Biomimetic Octacalcium Phosphate Bone Has Superior Bone Regeneration Ability Than Xenogeneic or Synthetic Bone

2021 ◽  
Author(s):  
Jooseong Kim ◽  
Sukyoung Kim ◽  
In-Hwan Song
Keyword(s):  
Bone Formation ◽  
Bone Regeneration ◽  
Mass Production ◽  
Bone Substitutes ◽  
Octacalcium Phosphate ◽  
Regeneration Ability ◽  
Bovine Bone ◽  
New Bone Formation ◽  
Apatite Crystals ◽  
Biological Apatite

Octacalcium phosphate (OCP) is a precursor of biological apatite crystals that has attracted attention as a possible bone substitute. On the other hand, few studies have examined this material at the experimental level due to the limitations of OCP mass production. Recently, mass production technology of OCP was developed, and the launch of OCP bone substitutes is occurring. In this study, the bone regeneration capacity of OCP products was compared with two of the most clinically used materials: heat-treated bovine bone (BHA) and sintered biphasic calcium phosphate (BCP). Twelve rabbits were used, and defects in each tibia were filled with OCP, BHA, BCP, and left unfilled as control (CON). The tibias were harvested at 4 and 12 weeks, and 15 μm slides were prepared using the diamond grinding method after being embedded in resin. Histological and histomorphometric analyses were performed to evaluate the bone regeneration ability and mechanism. The OCP showed significantly higher resorption and new bone formation in both periods analysed (p<0.05). Overall, OCP bone substitutes can enhance bone regeneration significantly by activating osteoblasts and a rapid phase transition of OCP crystals to biological apatite crystals (mineralisation), as well as providing additional space for new bone formation by rapid resorption.

scholarly journals Microporosities in 3D-Printed Tricalcium-Phosphate-Based Bone Substitutes Enhance Osteoconduction and Affect Osteoclastic Resorption

2020 ◽  
Vol 21 (23) ◽  
pp. 9270
Author(s):  
Chafik Ghayor ◽  
Tse-Hsiang Chen ◽  
Indranil Bhattacharya ◽  
Mutlu Özcan ◽  
Franz E. Weber
Keyword(s):  
Additive Manufacturing ◽  
Tricalcium Phosphate ◽  
Major Complication ◽  
Bone Substitutes ◽  
In Vivo Studies ◽  
Patient Specific ◽  
Osteoclastic Resorption ◽  
3D Printed ◽  
High Degree

Additive manufacturing is a key technology required to realize the production of a personalized bone substitute that exactly meets a patient’s need and fills a patient-specific bone defect. Additive manufacturing can optimize the inner architecture of the scaffold for osteoconduction, allowing fast and reliable defect bridging by promoting rapid growth of new bone tissue into the scaffold. The role of scaffold microporosity/nanoarchitecture in osteoconduction remains elusive. To elucidate this relationship, we produced lithography-based osteoconductive scaffolds from tricalcium phosphate (TCP) with identical macro- and microarchitecture, but varied their nanoarchitecture/microporosity by ranging maximum sintering temperatures from 1000 °C to 1200 °C. After characterization of the different scaffolds’ microporosity, compression strength, and nanoarchitecture, we performed in vivo studies that showed that ingrowth of bone as an indicator of osteoconduction significantly decreased with decreasing microporosity. Moreover, at the 1200 °C peak sinter temperature and lowest microporosity, osteoclastic degradation of the material was inhibited. Thus, even for wide-open porous TCP-based scaffolds, a high degree of microporosity appears to be essential for optimal osteoconduction and creeping substitution, which can prevent non-unions, the major complication during bone regeneration procedures.

scholarly journals Bone Substitutes: 3D Printed Porous Methacrylate/Silica Hybrid Scaffold for Bone Substitution (Adv. Healthcare Mater. 12/2021)

2021 ◽  
Vol 10 (12) ◽  
pp. 2170058
Author(s):  
Justin J. Chung ◽  
Jin Yoo ◽  
Brian S. T. Sum ◽  
Siwei Li ◽  
Soojin Lee ◽  
...  
Keyword(s):  
Bone Substitutes ◽  
Hybrid Scaffold ◽  
3D Printed ◽  
Silica Hybrid
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