scholarly journals Challenges of the modern antibody diagnostics in kidney transplantation

2014 ◽  
Vol 155 (46) ◽  
pp. 1820-1830 ◽  
Author(s):  
Dániel Wettstein ◽  
Dorottya Szentiványi
Keyword(s):  
Solid Phase ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Antibody Testing ◽  
Antibody Mediated Rejection ◽  
Transplant Patients ◽  
Leukocyte Antigens ◽  
Solid Phase Immunoassay ◽  
Kidney Transplant Patients ◽  
Review Reports

Overcoming antibody mediated rejection is of increasing interest in the field of transplantation immunology. The recipient’s antibodies against the graft human leukocyte antigens are responsible for antibody mediated graft injury. Introduction of the solid phase immunoassay technology radically changed the monitoring practice of antibodies against human leukocyte antigens, and this has consequences both for pretransplant and posttransplant phases, though our knowledge about the clinical interpretation of the detected antibodies is limited. This integrating review reports recommendations and algorithms regarding the management of kidney transplant patients. The detection of complement activation combined with the solid phase techniques is a promising new approach in antibody testing. The C4d and especially the more sensitive C1q methods have the potential to answer pivotal questions about the clinical relevance of antibodies. Answering the questions that the applied new methods raised and reviewing the recommendations are needed to remain up to date with this dynamically developing field. Orv. Hetil., 2014, 155(46), 1820–1830.

scholarly journals Optimal Immunosuppression Strategy in the Sensitized Kidney Transplant Recipient

2021 ◽  
Vol 10 (16) ◽  
pp. 3656
Author(s):  
Danae Olaso ◽  
Miriam Manook ◽  
Dimitrios Moris ◽  
Stuart Knechtle ◽  
Jean Kwun
Keyword(s):  
Immune Response ◽  
Transplant Recipient ◽  
Kidney Transplant Recipient ◽  
Human Leukocyte ◽  
Immunosuppressive Regimen ◽  
Human Leukocyte Antigens ◽  
Donor Pool ◽  
Hla Antibodies ◽  
Antibody Mediated Rejection ◽  
Leukocyte Antigens

Patients with previous sensitization events against anti-human leukocyte antigens (HLA) often have circulating anti-HLA antibodies. Following organ transplantation, sensitized patients have higher rates of antibody-mediated rejection (AMR) compared to those who are non-sensitized. More stringent donor matching is required for these patients, which results in a reduced donor pool and increased time on the waitlist. Current approaches for sensitized patients focus on reducing preformed antibodies that preclude transplantation; however, this type of desensitization does not modulate the primed immune response in sensitized patients. Thus, an optimized maintenance immunosuppressive regimen is necessary for highly sensitized patients, which may be distinct from non-sensitized patients. In this review, we will discuss the currently available therapeutic options for induction, maintenance, and adjuvant immunosuppression for sensitized patients.

scholarly journals The Role of Major Histocompatibility Complex in Organ Transplantation- Donor Specific Anti-Major Histocompatibility Complex Antibodies Analysis Goes to the Next Stage -

2019 ◽  
Vol 20 (18) ◽  
pp. 4544 ◽  
Author(s):  
Tsukasa Nakamura ◽  
Takayuki Shirouzu ◽  
Katsuya Nakata ◽  
Norio Yoshimura ◽  
Hidetaka Ushigome
Keyword(s):  
Major Histocompatibility Complex ◽  
Organ Transplantation ◽  
Current Knowledge ◽  
Human Leukocyte ◽  
Strongly Correlated ◽  
Human Beings ◽  
Major Histocompatibility ◽  
Antibody Mediated Rejection ◽  
Leukocyte Antigens ◽  
Histocompatibility Complex

Organ transplantation has progressed with the comprehension of the major histocompatibility complex (MHC). It is true that the outcome of organ transplantation largely relies on how well rejection is managed. It is no exaggeration to say that to be well acquainted with MHC is a shortcut to control rejection. In human beings, MHC is generally recognized as human leukocyte antigens (HLA). Under the current circumstances, the number of alleles is still increasing, but the function is not completely understood. Their roles in organ transplantation are of vital importance, because mismatches of HLA alleles possibly evoke both cellular and antibody-mediated rejection. Even though the control of cellular rejection has improved by recent advances of immunosuppressants, there is no doubt that antibody-mediated rejection (AMR), which is strongly correlated with donor-specific anti-HLA antibodies (DSA), brings a poor outcome. Thus, to diagnose and treat AMR correctly is a clear proposition. In this review, we would like to focus on the detection of intra-graft DSA as a recent trend. Overall, here we will review the current knowledge regarding MHC, especially with intra-graft DSA, and future perspectives: HLA epitope matching; eplet risk stratification; predicted indirectly recognizable HLA epitopes etc. in the context of organ transplantation.

scholarly journals Human leukocyte antigens are associated with salivary level of active MMP ‐8

2021 ◽  
Author(s):  
Matti Mauramo ◽  
Elina Mauramo ◽  
Timo Sorsa ◽  
Taina Tervahartiala ◽  
Ismo T. Räisänen ◽  
...  
Keyword(s):  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Leukocyte Antigens ◽  
Salivary Level

scholarly journals Selective deletion of human leukocyte antigens protects stem cell-derived islets from immune rejection

Cell Reports ◽  
2021 ◽  
Vol 36 (7) ◽  
pp. 109538
Author(s):  
Audrey V. Parent ◽  
Gaetano Faleo ◽  
Jessica Chavez ◽  
Michael Saxton ◽  
David I. Berrios ◽  
...  
Keyword(s):  
Stem Cell ◽  
Human Leukocyte ◽  
Human Leukocyte Antigens ◽  
Immune Rejection ◽  
Leukocyte Antigens
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