Solid-phase assays for the detection of alloantibody against human leukocyte antigens: Panacea or Pandora?

2014 ◽  
Vol 41 (5) ◽  
pp. 362-369 ◽  
Author(s):  
T. Roberts ◽  
G. Tumer ◽  
H. M. Gebel ◽  
R. A. Bray
2014 ◽  
Vol 155 (46) ◽  
pp. 1820-1830 ◽  
Author(s):  
Dániel Wettstein ◽  
Dorottya Szentiványi

Overcoming antibody mediated rejection is of increasing interest in the field of transplantation immunology. The recipient’s antibodies against the graft human leukocyte antigens are responsible for antibody mediated graft injury. Introduction of the solid phase immunoassay technology radically changed the monitoring practice of antibodies against human leukocyte antigens, and this has consequences both for pretransplant and posttransplant phases, though our knowledge about the clinical interpretation of the detected antibodies is limited. This integrating review reports recommendations and algorithms regarding the management of kidney transplant patients. The detection of complement activation combined with the solid phase techniques is a promising new approach in antibody testing. The C4d and especially the more sensitive C1q methods have the potential to answer pivotal questions about the clinical relevance of antibodies. Answering the questions that the applied new methods raised and reviewing the recommendations are needed to remain up to date with this dynamically developing field. Orv. Hetil., 2014, 155(46), 1820–1830.


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Cell Reports ◽  
2021 ◽  
Vol 36 (7) ◽  
pp. 109538
Author(s):  
Audrey V. Parent ◽  
Gaetano Faleo ◽  
Jessica Chavez ◽  
Michael Saxton ◽  
David I. Berrios ◽  
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PLoS ONE ◽  
2014 ◽  
Vol 9 (1) ◽  
pp. e86007 ◽  
Author(s):  
Nawarat Posuwan ◽  
Sunchai Payungporn ◽  
Pisit Tangkijvanich ◽  
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2021 ◽  
Vol 67 (04/2021) ◽  
Author(s):  
Daming Wang ◽  
Wen Ma ◽  
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Yiwen Zhou

Author(s):  
Emeline Masson Frenet ◽  
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