scholarly journals Connections between apolipoprotein E genotypes and the development of cardiovascular diseases

2012 ◽  
Vol 153 (52) ◽  
pp. 2070-2076 ◽  
Author(s):  
Csaba Végh ◽  
Zoltán Langmár ◽  
Melinda Szerző ◽  
Annamária Ágota ◽  
Krisztina Marosi ◽  
...  
Keyword(s):  
Cardiovascular Diseases ◽  
Apolipoprotein E ◽  
Metabolic Pathways ◽  
Causes Of Death ◽  
Lipid Level ◽  
Plasma Lipid ◽  
Wild Type ◽  
Plasma Lipid Level ◽  
Apolipoprotein E Genotypes ◽  
Hyperlipoproteinemia Type Iii

Elevated plasma lipid level is one of the main risk factors for cardiovascular diseases, which are considered to be pimary causes of death. Apolipoprotein E plays a part in the lipid transport in the blood, thus polimophisms of that affect the lipid composition of the plasma. The three most common alleles of apolipoprotein E are e2, e3, e4. Out of the two non-wild type alleles, the e2 and e4, the latter was shown to play a role in the development of cardiovascular diseases and Alzheimer’s disease. Some studies mention the e2/e2 homozygote genotype as one of the causes of hyperlipoproteinemia type III. Besides lipid metabolism, apolipoprotein E also influences the manifestation of cardiovascular diseases through other biochemical pathways, therefore it is essential to explore the molecular background of these metabolic pathways. Orv. Hetil., 2012, 153, 2070–2076.

scholarly journals Body Build and Plasma Lipid Level

1965 ◽  
Vol 29 (10) ◽  
pp. 937-942 ◽  
Author(s):  
KAORU OYAMA ◽  
HARUO UZAWA ◽  
MASAKI MATSUDA ◽  
KUNITARO IMAICH
Keyword(s):  
Lipid Level ◽  
Plasma Lipid ◽  
Plasma Lipid Level ◽  
Body Build

A Novel Mechanism for Decreasing Plasma Lipid Level from Imidazoline I-1 Receptor Activation in High Fat Diet-fed Mice

2011 ◽  
Vol 43 (07) ◽  
pp. 458-463 ◽  
Author(s):  
C-S. Niu ◽  
H-T. Wu ◽  
K-C. Cheng ◽  
K-C. Lin ◽  
C-T. Chen ◽  
...  
Keyword(s):  
High Fat Diet ◽  
Lipid Level ◽  
Plasma Lipid ◽  
Receptor Activation ◽  
High Fat ◽  
Plasma Lipid Level

Normotriglyceridemic Abetalipoproteinemia in Infancy: An Isolated Apolipoprotein B-100 Deficiency

PEDIATRICS ◽  
1985 ◽  
Vol 75 (3) ◽  
pp. 541-546
Author(s):  
Yoshiki Takashima ◽  
Tatsuhiko Kodama ◽  
Hisaya lida ◽  
Masahiko Kawamura ◽  
Hiroyuki Aburatani ◽  
...  
Keyword(s):  
Lipid Level ◽  
Sodium Dodecylsulfate ◽  
Plasma Lipid ◽  
Plasma Lipoproteins ◽  
High Density Lipoproteins ◽  
Plasma Lipid Level ◽  
Apoprotein B ◽  
Old Japanese ◽  
Faint Band ◽  
Low Levels

The plasma lipoproteins of a 1-year-old Japanese infant were studied because of malnutrition, severe decrease in plasma lipid level, and acanthocytosis. Plasma lipoprotein analysis revealed that low-density lipoproteins were deficient; however, low levels of triglyceride-rich lipoproteins were found in the plasma. On sodium dodecylsulfate (SDS) polyacrylamide gel electro-phoresis, apoprotein B-48 and a faint band corresponding to apoprotein B-100 were detected in the lipoprotein fraction of density < 1.006 g/mL when the infant was 6 months old. Apoprotein B-48 was more clearly detected after 1 year, but the band corresponding to apoprotein B-100 on the sodium dodecylsulfate gel electrophoresis had disappeared. The apoprotein B-48 content of the fraction with density < 1.006 g/mL was about 0.05 to 0.3 mg/dL. The patient's lipoproteins consisted mainly of high-density lipoproteins. These results suggest that the disorder in this patient is caused by apoprotein B-100 deficiency.

scholarly journals The Effects of Low-Intensity Ultrasound on Fat Reduction of Rat Model

2017 ◽  
Vol 2017 ◽  
pp. 1-8 ◽  
Author(s):  
Bill Zhou ◽  
Benny Yuk Kin Leung ◽  
Lei Sun
Keyword(s):  
Body Fat ◽  
Lipid Level ◽  
Subcutaneous Fat ◽  
Body Contouring ◽  
Plasma Lipid ◽  
High Intensity Focused Ultrasound ◽  
Plasma Lipid Level ◽  
Low Intensity ◽  
Fat Reduction ◽  
Low Intensity Ultrasound

Nonfocused low-intensity ultrasound is generally believed to be less efficacious than High-Intensity Focused Ultrasound (HIFU) at body fat reduction; nevertheless, this technology has already been widely used clinically for body contouring purposes. This study aimed to evaluate the efficacy and safety of this new technology by applying 1 MHz nonfocused ultrasound at 3 W/cm2to the outer-thigh region of rat models. Ultrasonography measurement demonstrated an average reduction of 0.5 mm of subcutaneous fat thickness that persisted for at least three days after treatment. Biochemical analysis quantified a significant increase in lipid levels, specifically triglyceride, high-density lipoprotein, and total cholesterol. These two findings of subcutaneous fat reduction and plasma lipid increase showed a positive correlation. No evidence of adverse events or complications was observed after the treatment. This study validated nonfocused low-intensity ultrasound as an effective and safe method for body fat reduction, especially with repetitive treatment. However, the concurrent increase in plasma lipid level will require further investigation to determine this technology’s long-term impact, if any, on health.

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