Comparison of diversity of torque teno virus 1 in different mucosal tissues and disorders

2011 ◽  
Vol 58 (4) ◽  
pp. 319-337 ◽  
Author(s):  
Enikő Fehér ◽  
Gábor Kardos ◽  
Tamás Gáll ◽  
Andrea Kis ◽  
Lajos Gergely ◽  
...  
Keyword(s):  
Torque Teno Virus ◽  
Mucosal Tissues

scholarly journals Characterisation of antifungal C‐type lectin receptor expression on murine epithelial and endothelial cells in mucosal tissues

2021 ◽  
Author(s):  
Mark H.T. Stappers ◽  
Christina Nikolakopoulou ◽  
Darin L. Wiesner ◽  
Raif Yuecel ◽  
Bruce S. Klein ◽  
...  
Keyword(s):  
Endothelial Cells ◽  
Receptor Expression ◽  
Lectin Receptor ◽  
Mucosal Tissues

Viral infections in common carp lead to a disturbance of mucin expression in mucosal tissues

2017 ◽  
Vol 71 ◽  
pp. 353-358 ◽  
Author(s):  
Mikolaj Adamek ◽  
Dennis Hazerli ◽  
Marek Matras ◽  
Felix Teitge ◽  
Michal Reichert ◽  
...  
Keyword(s):  
Common Carp ◽  
Viral Infections ◽  
Mucosal Tissues ◽  
Mucin Expression

Isolation and in vitro permeation of phenylpropylamino alkaloids from Khat (Catha edulis) across oral and intestinal mucosal tissues

2016 ◽  
Vol 194 ◽  
pp. 307-315 ◽  
Author(s):  
Minaleshewa Atlabachew ◽  
Sandra Combrinck ◽  
Alvaro M. Viljoen ◽  
Josias H. Hamman ◽  
Chrisna Gouws
Keyword(s):  
Catha Edulis ◽  
Mucosal Tissues ◽  
In Vitro Permeation

scholarly journals Dietary supplementation with Bifidobacterium lactis NCC2818 from weaning reduces local immunoglobulin production in lymphoid-associated tissues but increases systemic antibodies in healthy neonates

2013 ◽  
Vol 110 (7) ◽  
pp. 1243-1252 ◽  
Author(s):  
Marie C. Lewis ◽  
Dilip V. Patel ◽  
Jenni Fowler ◽  
Swantje Duncker ◽  
Adrian W. Zuercher ◽  
...  
Keyword(s):  
Immune System ◽  
Health Benefit ◽  
Dietary Supplementation ◽  
Nutritional Intervention ◽  
Dietary Interventions ◽  
Probiotic Supplementation ◽  
Human Infants ◽  
Bifidobacterium Lactis ◽  
Beneficial Effects ◽  
Mucosal Tissues

Weaning is associated with a major shift in the microbial community of the intestine, and this instability may make it more acquiescent than the adult microbiota to long-term changes. Modulation achieved through dietary interventions may have potentially beneficial effects on the developing immune system, which is driven primarily by the microbiota. The specific aim of the present study was to determine whether immune development could be modified by dietary supplementation with the human probiotic Bifidobacterium lactis NCC2818 in a tractable model of weaning in infants. Piglets were reared by their mothers before being weaned onto a solid diet supplemented with B. lactis NCC2818, while sibling controls did not receive supplementation. Probiotic supplementation resulted in a reduction in IgA (P< 0·0005) and IgM (P< 0·009) production by mucosal tissues but had no effect on IgG production (P>0·05). Probiotic-supplemented pigs had more mast cells than unsupplemented littermates (P< 0·0001), although numbers in both groups were low. In addition, the supplemented piglets made stronger serum IgG responses to fed and injected antigens (P< 0·05). The present findings are consistent with B. lactis NCC2818 reducing intestinal permeability induced by weaning, and suggest that the piglet is a valuable intermediate between rodent models and human infants. The results also strongly suggest that measures of the effect of probiotic supplementation on the immune system need to be interpreted carefully as proxy measures of health benefit. However, they are useful in developing an understanding of the mechanism of action of probiotic strains, an important factor in predicting favourable health outcomes of nutritional intervention.

scholarly journals Human Mucosal Mast Cells Capture HIV-1 and Mediate Viraltrans-Infection of CD4+T Cells

2015 ◽  
Vol 90 (6) ◽  
pp. 2928-2937 ◽  
Author(s):  
Ai-Ping Jiang ◽  
Jin-Feng Jiang ◽  
Ji-Fu Wei ◽  
Ming-Gao Guo ◽  
Yan Qin ◽  
...  
Keyword(s):  
T Cells ◽  
Mast Cells ◽  
Cell Surface ◽  
Bacterial Infections ◽  
Mucosal Mast Cells ◽  
Mucosal Tissues ◽  
Viral Particles ◽  
Molecular Patterns ◽  
Hiv 1

ABSTRACTThe gastrointestinal mucosa is the primary site where human immunodeficiency virus type 1 (HIV-1) invades, amplifies, and becomes persistently established, and cell-to-cell transmission of HIV-1 plays a pivotal role in mucosal viral dissemination. Mast cells are widely distributed in the gastrointestinal tract and are early targets for invasive pathogens, and they have been shown to have increased density in the genital mucosa in HIV-infected women. Intestinal mast cells express numerous pathogen-associated molecular patterns (PAMPs) and have been shown to combat various viral, parasitic, and bacterial infections. However, the role of mast cells in HIV-1 infection is poorly defined. In this study, we investigated their potential contributions to HIV-1 transmission. Mast cells isolated from gut mucosal tissues were found to express a variety of HIV-1 attachment factors (HAFs), such as DC-SIGN, heparan sulfate proteoglycan (HSPG), and α4β7 integrin, which mediate capture of HIV-1 on the cell surface. Intriguingly, following coculture with CD4+T cells, mast cell surface-bound viruses were efficiently transferred to target T cells. Prior blocking with anti-HAF antibody or mannan before coculture impaired viraltrans-infection. Cell-cell conjunctions formed between mast cells and T cells, to which viral particles were recruited, and these were required for efficient cell-to-cell HIV-1 transmission. Our results reveal a potential function of gut mucosal mast cells in HIV-1 dissemination in tissues. Strategies aimed at preventing viral capture and transfer mediated by mast cells could be beneficial in combating primary HIV-1 infection.IMPORTANCEIn this study, we demonstrate the role of human mast cells isolated from mucosal tissues in mediating HIV-1trans-infection of CD4+T cells. This finding facilitates our understanding of HIV-1 mucosal infection and will benefit the development of strategies to combat primary HIV-1 dissemination.

scholarly journals Dendritic Cells in Distinct Oral Mucosal Tissues Engage Different Mechanisms To Prime CD8+T Cells

2010 ◽  
Vol 186 (2) ◽  
pp. 891-900 ◽  
Author(s):  
Itay Nudel ◽  
Mazal Elnekave ◽  
Karina Furmanov ◽  
Moran Arizon ◽  
Björn E. Clausen ◽  
...  
Keyword(s):  
T Cells ◽  
Dendritic Cells ◽  
Cd8 T Cells ◽  
Mucosal Tissues

scholarly journals Quercetin Administration Suppresses the Cytokine Storm in Myeloid and Plasmacytoid Dendritic Cells

2021 ◽  
Vol 22 (15) ◽  
pp. 8349
Author(s):  
Giulio Verna ◽  
Marina Liso ◽  
Elisabetta Cavalcanti ◽  
Giusy Bianco ◽  
Veronica Di Sarno ◽  
...  
Keyword(s):  
Dendritic Cells ◽  
Intestinal Barrier ◽  
Plasmacytoid Dendritic Cells ◽  
Myeloid Dendritic Cells ◽  
Soluble Factors ◽  
Secreted Factors ◽  
Mucosal Tissues ◽  
Basolateral Side ◽  
Bowel Diseases ◽  
Inflammatory Bowel

Dendritic cells (DCs) can be divided by lineage into myeloid dendritic cells (mDCs) and plasmacytoid dendritic cells (pDCs). They both are present in mucosal tissues and regulate the immune response by secreting chemokines and cytokines. Inflammatory bowel diseases (IBDs) are characterized by a leaky intestinal barrier and the consequent translocation of bacterial lipopolysaccharide (LPS) to the basolateral side. This results in DCs activation, but the response of pDCs is still poorly characterized. In the present study, we compared mDCs and pDCs responses to LPS administration. We present a broad panel of DCs secreted factors, including cytokines, chemokines, and growth factors. Our recent studies demonstrated the anti-inflammatory effects of quercetin administration, but to date, there is no evidence about quercetin’s effects on pDCs. The results of the present study demonstrate that pDCs can respond to LPS and that quercetin exposure modulates soluble factors release through the same molecular pathway used by mDCs (Slpi, Hmox1, and AP-1).

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