Isolation and in vitro permeation of phenylpropylamino alkaloids from Khat (Catha edulis) across oral and intestinal mucosal tissues

2016 ◽  
Vol 194 ◽  
pp. 307-315 ◽  
Author(s):  
Minaleshewa Atlabachew ◽  
Sandra Combrinck ◽  
Alvaro M. Viljoen ◽  
Josias H. Hamman ◽  
Chrisna Gouws
Keyword(s):  
Catha Edulis ◽  
Mucosal Tissues ◽  
In Vitro Permeation

Formulation and Evaluation of Carbopol Gel Containing Liposomes of Ketoconazole. (Part-II)

2009 ◽  
Vol 1 (2) ◽  
Author(s):  
Rakesh Patel ◽  
Hardik Patel ◽  
Ashok Baria
Keyword(s):  
Antifungal Activity ◽  
Rat Skin ◽  
Albino Rat ◽  
In Vitro Drug Release ◽  
Carbopol Gel ◽  
Liposomal Formulations ◽  
Release Drug ◽  
In Vitro Permeation ◽  
In Vitro Antifungal Activity

The aim of this work was to prepare and evaluate the topical carbopol gel formulation containing ketoconazole encapsulated liposomes. Ketoconazole loaded liposomes were prepared by thin film hydration technique. The prepared liposomes were incorporated into 1% carbopol gel, and the systems were evaluated for in-vitro drug release, drug retention into skin and in-vitro antifungal activity. The in-vitro permeation of ketoconazole using wistar albino rat skin from liposomal gel was compared with that of plain drug gel and also with plain drug cream containing 2% w/w of ketoconazole. The release of ketoconazole from liposomal gel was much slower than from non liposomal formulations. Gel containing liposomal ketoconazole showed maximum antifungal activity after 30 hours over plain ketoconazole gel and cream formulations.

scholarly journals Tyrosol-Enriched Tomatoes by Diffusion across the Fruit Peel from a Chitosan Coating: A Proposal of Functional Food

Foods ◽  
2021 ◽  
Vol 10 (2) ◽  
pp. 335
Author(s):  
Silvia Tampucci ◽  
Antonella Castagna ◽  
Daniela Monti ◽  
Clementina Manera ◽  
Giuseppe Saccomanni ◽  
...  
Keyword(s):  
Tomato Fruit ◽  
Storage Period ◽  
Food Matrix ◽  
Fruit Peel ◽  
Fresh Food ◽  
In Vitro Permeation ◽  
Active Transfer

Chitosan is receiving increasing attention from the food industry for being a biodegradable, non-toxic, antimicrobial biopolymer able to extend the shelf life of, and preserve the quality of, fresh food. However, few studies have investigated the ability of chitosan-based coatings to allow the diffusion of bioactive compounds into the food matrix to improve its nutraceutical quality. This research is aimed at testing whether a hydrophilic molecule (tyrosol) could diffuse from the chitosan-tyrosol coating and cross the tomato peel. To this end, in vitro permeation tests using excised tomato peel and an in vivo application of chitosan-tyrosol coating on tomato fruit, followed by tyrosol quantification in intact fruit, peel and flesh during a seven-day storage at room temperature, were performed. Both approaches demonstrated the ability of tyrosol to permeate across the fruit peel. Along with a decreased tyrosol content in the peel, its concentration within the flesh was increased, indicating an active transfer of tyrosol into this tissue. This finding, together with the maintenance of constant tyrosol levels during the seven-day storage period, is very promising for the use of chitosan formulations to produce functional tomato fruit.

scholarly journals Dermal delivery of amitriptyline for topical analgesia

2021 ◽  
Author(s):  
Chin-Ping Kung ◽  
Bruno C. Sil ◽  
Yanling Zhang ◽  
Jonathan Hadgraft ◽  
Majella E. Lane ◽  
...  
Keyword(s):  
Treatment Options ◽  
Isopropyl Myristate ◽  
Promising Candidate ◽  
In Vitro Permeation ◽  
Base Form ◽  
Dermal Delivery ◽  
Phosphate Buffered Saline ◽  
Topical Analgesia ◽  
Topical Analgesic

Abstract Amitriptyline, administered orally, is currently one of the treatment options for the management of neuropathic pain and migraine. Because of the physicochemical properties of the molecule, amitriptyline is also a promising candidate for delivery as a topical analgesic. Here we report the dermal delivery of amitriptyline from a range of simple formulations. The first stage of the work required the conversion of amitriptyline hydrochloride to the free base form as confirmed by nuclear magnetic resonance (NMR). Distribution coefficient values were measured at pH 6, 6.5, 7, and 7.4. Solubility and stability of amitriptyline were assessed prior to conducting in vitro permeation and mass balance studies. The compound demonstrated instability in phosphate-buffered saline (PBS) dependent on pH. Volatile formulations comprising of isopropyl alcohol (IPA) and isopropyl myristate (IPM) or propylene glycol (PG) were evaluated in porcine skin under finite dose conditions. Compared with neat IPM, the IPM:IPA vehicles promoted 8-fold and 5-fold increases in the amount of amitriptyline that permeated at 24 h. Formulations containing PG also appear to be promising vehicles for dermal delivery of amitriptyline, typically delivering higher amounts of amitriptyline than the IPM:IPA vehicles. The results reported here suggest that further optimization of topical amitriptyline formulations should be pursued towards development of a product for clinical investigational studies. Graphical abstract

scholarly journals Iontophoresis of micellar composition of Lovastatin: Study of affecting factors and in-vitro permeation

2013 ◽  
Vol 7 (4) ◽  
pp. 327-330 ◽  
Author(s):  
Jayrajsinh I. Sarvaiya ◽  
Gourishankar K. Kapse ◽  
Chintan J. Tank
Keyword(s):  
Affecting Factors ◽  
In Vitro Permeation

In vitro permeation of gold nanoparticles through rat skin and rat intestine: Effect of particle size

2008 ◽  
Vol 65 (1) ◽  
pp. 1-10 ◽  
Author(s):  
Ganeshchandra Sonavane ◽  
Keishiro Tomoda ◽  
Akira Sano ◽  
Hiroyuki Ohshima ◽  
Hiroshi Terada ◽  
...  
Keyword(s):  
Particle Size ◽  
Gold Nanoparticles ◽  
Rat Skin ◽  
Rat Intestine ◽  
In Vitro Permeation ◽  
Effect Of Particle Size

Deformable Surfactant Vesicles Loading Ammonium Glycyrrhizinate: Characterization and In Vitro Permeation Studies

2012 ◽  
Vol 9 (5) ◽  
pp. 494-499 ◽  
Author(s):  
Luisa Di Marzio ◽  
Carlotta Marianecci ◽  
Federica Rinaldi ◽  
Sara Esposito ◽  
Maria Carafa
Keyword(s):  
Surfactant Vesicles ◽  
In Vitro Permeation ◽  
Permeation Studies
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