scholarly journals 2-es típusú diabetesesek és nem cukorbetegek területen szerzett, belgyógyászati osztályos felvételt igénylő bakteriális infekcióinak klinikai összehasonlítása

2019 ◽  
Vol 160 (41) ◽  
pp. 1623-1632
Author(s):  
László József Barkai ◽  
Emese Sipter ◽  
Dorottya Csuka ◽  
Tímea Baló ◽  
Zsuzsa Nébenführer ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Bacterial Infections ◽  
Respiratory Infections ◽  
Mortality Rates ◽  
Medical Ward ◽  
Soft Tissue Infections ◽  
General Medical Ward ◽  
International Data ◽  
Tract Infections

Abstract: Introduction: Previous data showed bacterial infections among diabetic patients to be more serious and frequent, with higher mortality rates in comparison with non-diabetics. Recent investigations, however, are contradictory. Aim: The goal of our prospective, observational study was to compare patients hospitalized on a general medical ward due to community-acquired bacterial infections with type 2 diabetes mellitus (T2DM) to those of non-diabetics (K) by 1) infection localization, 2) spectrum of pathogens, 3) three-month mortality rates. Method: Patients were consecutively involved (T2DM: n = 205, K: n = 202). We characterized the infections, clinical parameters, mortalities of the two groups, and matched them to international data. Results: No difference regarding clinical details of the groups were found except for glycemic parameters and BMI. In the T2DM group the skin- and soft tissue- (37.1%), in the K patients respiratory infections (37.1%) were the most common, followed by urinary ones (31.2% and 31.7%, respectively). Skin- and soft tissue infection incidence among T2DM subjects were higher compared to international results (37.1% vs. 16%). Co-presence of Gram positive and Gram negative bacteria in the skin- and soft tissue infections (23/76 vs. 5/46, p = 0.0149), and polymicrobial origin in the urinary tract infections (34.0% vs. 15.1%, p = 0.0335) were found to be more frequent in T2DM than in K. No difference regarding mortality rates were detected. In T2DM the skin- and soft tissue while in the K group the respiratory infections had the most death counts. Conclusions: We found higher rates of skin- and soft tissue infections among T2DM patients hospitalized on a general medical ward compared to international data. In total we did not find difference regarding three-month mortality between the groups. Our results highlight the importance of primary prevention and shows its inadequacy concerning skin and soft tissue infections among type 2 diabetics in Hungary. Orv Hetil. 2019; 160(41): 1623–1632.

scholarly journals Comparing the quantity and quality of randomised placebo-controlled trials of antibiotics for acute respiratory, urinary, and skin and soft tissue infections: a scoping review

BJGP Open ◽  
2020 ◽  
Vol 4 (4) ◽  
pp. bjgpopen20X101082
Author(s):  
Mina Bakhit ◽  
Tammy Hoffmann ◽  
Miriam Santer ◽  
Matthew Ridd ◽  
Nick Francis ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Scoping Review ◽  
Respiratory Infections ◽  
Controlled Trials ◽  
Cochrane Central Register ◽  
Soft Tissue Infections ◽  
High Quality ◽  
Gradual Improvement ◽  
Tract Infections

BackgroundThe management of acute respiratory infections (ARIs), urinary tract infections (UTIs), and skin and soft tissue infections (SSTIs) should be guided by high quality evidence.AimTo compare the quantity and quality of randomised placebo-controlled trials of antibiotics for ARIs, UTIs, and SSTIs.Design & settingA scoping review of the literature was performed using comprehensive search strategies.MethodPubMed and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched for published studies from inception until 17 April 2019. Randomised controlled trials (RCTs) that compared participants in primary care or in the community who had uncomplicated acute ARI, UTI, or studies, and were randomised to antibiotic or placebo (or no active treatment), were eligible for inclusion. Two groups of researchers independently screened articles for inclusion, extracted data, and assessed the quality of included studies.ResultsA total of 108 eligible studies were identified: 80 on ARI, eight on UTI, and 20 on SSTI. The quality of studies varied with unclear risk of bias (RoB) prevalent in many domains. There was a gradual improvement in the quality of trials investigating ARIs over time, which could not be assessed in SSTI and UTI studies.ConclusionThis review highlights a sparsity of trials assessing the effectiveness of antibiotics in people with UTIs and SSTIs, compared to trials targeting ARIs. This gap in the evidence needs to be addressed by conducting further high quality trials on the effects of antibiotics in patients with UTI and SSTI.

scholarly journals Bacterial infections in patients hospitalized with COVID-19

2021 ◽  
Author(s):  
Víctor Moreno-Torres ◽  
Carmen de Mendoza ◽  
Sara de la Fuente ◽  
Enrique Sánchez ◽  
María Martínez-Urbistondo ◽  
...  
Keyword(s):  
Neurological Disease ◽  
Bacterial Infections ◽  
Multivariate Analyses ◽  
Survival Rates ◽  
Mortality Rates ◽  
Tertiary Hospital ◽  
Older Age ◽  
Soft Tissue Infections ◽  
Tract Infections ◽  
Abdominal Infections

AbstractBacterial infections may complicate the course of COVID-19 patients. The rate and predictors of bacterial infections were examined in patients consecutively admitted with COVID-19 at one tertiary hospital in Madrid between March 1st and April 30th, 2020. Among 1594 hospitalized patients with COVID-19, 135 (8.5%) experienced bacterial infectious events, distributed as follows: urinary tract infections (32.6%), bacteremia (31.9%), pneumonia (31.8%), intra-abdominal infections (6.7%) and skin and soft tissue infections (6.7%). Independent predictors of bacterial infections were older age, neurological disease, prior immunosuppression and ICU admission (p < 0.05). Patients with bacterial infections who more frequently received steroids and tocilizumab, progressed to lower Sap02/FiO2 ratios, and experienced more severe ARDS (p < 0.001). The mortality rate was significantly higher in patients with bacterial infections as compared to the rest (25% vs 6.7%, respectively; p < 0.001). In multivariate analyses, older age, prior neurological or kidney disease, immunosuppression and ARDS severity were associated with an increased mortality (p < 0.05) while bacterial infections were not. Conversely, the use of steroids or steroids plus tocilizumab did not confer a higher risk of bacterial infections and improved survival rates. Bacterial infections occurred in 8.5% of patients hospitalized with COVID-19 during the first wave of the pandemic. They were not independently associated with increased mortality rates. Baseline COVID-19 severity rather than the incidence of bacterial infections seems to contribute to mortality. When indicated, the use of steroids or steroids plus tocilizumab might improve survival in this population.

scholarly journals A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiologya

2018 ◽  
Vol 67 (6) ◽  
pp. e1-e94 ◽  
Author(s):  
J Michael Miller ◽  
Matthew J Binnicker ◽  
Sheldon Campbell ◽  
Karen C Carroll ◽  
Kimberle C Chapin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Infectious Diseases ◽  
Clinical Medicine ◽  
Respiratory Infections ◽  
Disease Diagnosis ◽  
Etiologic Agent ◽  
Healthcare Team ◽  
Soft Tissue Infections ◽  
Microbiology Laboratory ◽  
Tract Infections

Abstract The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician/advanced practice provider and the microbiologists who provide enormous value to the healthcare team. This document, developed by experts in laboratory and adult and pediatric clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. This document presents a system-based approach rather than specimen-based approach, and includes bloodstream and cardiovascular system infections, central nervous system infections, ocular infections, soft tissue infections of the head and neck, upper and lower respiratory infections, infections of the gastrointestinal tract, intra-abdominal infections, bone and joint infections, urinary tract infections, genital infections, and other skin and soft tissue infections; or into etiologic agent groups, including arthropod-borne infections, viral syndromes, and blood and tissue parasite infections. Each section contains introductory concepts, a summary of key points, and detailed tables that list suspected agents; the most reliable tests to order; the samples (and volumes) to collect in order of preference; specimen transport devices, procedures, times, and temperatures; and detailed notes on specific issues regarding the test methods, such as when tests are likely to require a specialized laboratory or have prolonged turnaround times. In addition, the pediatric needs of specimen management are also emphasized. There is intentional redundancy among the tables and sections, as many agents and assay choices overlap. The document is intended to serve as a guidance for physicians in choosing tests that will aid them to quickly and accurately diagnose infectious diseases in their patients.

STUDY ON THE BACTERIA THAT CAUSE HOSPITAL INFECTIONS AT HUE CENTRAL HOSPITAL IN 2012

2012 ◽  
pp. 100-108
Author(s):  
Dien Hai Truong ◽  
Dinh Binh Tran ◽  
Thi Nam Lien Nguyen ◽  
et al
Keyword(s):  
Soft Tissue ◽  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
Bloodstream Infections ◽  
Soft Tissue Infections ◽  
Hospital Infections ◽  
Central Hospital ◽  
Local Hospital ◽  
Tract Infections ◽  
Common Infections

Objective: To study the bacterial etiologies causing hospital infections at Hue Central Hospital to determine the type of bacteria causing major hospital infections, distribution by local hospital infections, treatment areas contributing to control hospital infections. Subjects and methods: The study described on 311 bacteria strains that isolated in 242 patients who sufer hospital infections with 261 samples from 5/2011 to 5/2012. Results, discussion and conclusions: Hospital infections were 66.9% in male and 33.1%) in female patients, with 261 specimens we isolated 311 bacterial that cause hospital infections. - Respiratory tract infections were the highest rate (37.2%), followed by wound infection (20.2%) and the skin and soft tissue infections (13.2%), bloodstream infections (12,8%). - Five kinds of common infections were: respiratory infections, surgical wound infections, skin and soft tissue infections, urinary tract infections, blood infections. - Sputum is mainly specimens that accounted 35.2%, followed by 34.9% pus specimens, remaining is all kinds of other specimens. - Hospital infections due to Gram-negative bacteria 83.9% that was 5.2 times higher than that of Gram-positive bacterial (16.1%). - The bacterial etiologies causing hospital infections in Hue Central Hospital have five major types: the highest is Acinetobacter baumannii (27.3%), followed by Klebsiella pneumoniae (23.8%), Escherichia coli (15.8%), Staphylococcus aureus (10.6%), Pseudomonas aeruginosa (7.1%). - There are 43 specimens that were isolated two or more types of bacteria (16.5%).

A Guide to Utilization of the Microbiology Laboratory for Diagnosis of Infectious Diseases: 2018 Update by the Infectious Diseases Society of America and the American Society for Microbiologya

2018 ◽  
Vol 67 (6) ◽  
pp. 813-816 ◽  
Author(s):  
J Michael Miller ◽  
Matthew J Binnicker ◽  
Sheldon Campbell ◽  
Karen C Carroll ◽  
Kimberle C Chapin ◽  
...  
Keyword(s):  
Soft Tissue ◽  
Infectious Diseases ◽  
Clinical Medicine ◽  
Respiratory Infections ◽  
Disease Diagnosis ◽  
Etiologic Agent ◽  
Healthcare Team ◽  
Soft Tissue Infections ◽  
Microbiology Laboratory ◽  
Tract Infections

Abstract The critical nature of the microbiology laboratory in infectious disease diagnosis calls for a close, positive working relationship between the physician/advanced practice provider and the microbiologists who provide enormous value to the healthcare team. This document, developed by experts in laboratory and adult and pediatric clinical medicine, provides information on which tests are valuable and in which contexts, and on tests that add little or no value for diagnostic decisions. This document presents a system-based approach rather than specimen-based approach, and includes bloodstream and cardiovascular system infections, central nervous system infections, ocular infections, soft tissue infections of the head and neck, upper and lower respiratory infections, infections of the gastrointestinal tract, intra-abdominal infections, bone and joint infections, urinary tract infections, genital infections, and other skin and soft tissue infections; or into etiologic agent groups, including arthropod-borne infections, viral syndromes, and blood and tissue parasite infections. Each section contains introductory concepts, a summary of key points, and detailed tables that list suspected agents; the most reliable tests to order; the samples (and volumes) to collect in order of preference; specimen transport devices, procedures, times, and temperatures; and detailed notes on specific issues regarding the test methods, such as when tests are likely to require a specialized laboratory or have prolonged turnaround times. In addition, the pediatric needs of specimen management are also emphasized. There is intentional redundancy among the tables and sections, as many agents and assay choices overlap. The document is intended to serve as a guidance for physicians in choosing tests that will aid them to quickly and accurately diagnose infectious diseases in their patients.

scholarly journals Comparative Genomics ofEscherichia coliIsolated from Skin and Soft Tissue and Other Extraintestinal Infections

mBio ◽  
2017 ◽  
Vol 8 (4) ◽  
Author(s):  
Amit Ranjan ◽  
Sabiha Shaik ◽  
Nishant Nandanwar ◽  
Arif Hussain ◽  
Sumeet K. Tiwari ◽  
...  
Keyword(s):  
Escherichia Coli ◽  
Comparative Genomics ◽  
Soft Tissue ◽  
Multidrug Resistant ◽  
Primary Concern ◽  
Beta Lactamase ◽  
Soft Tissue Infections ◽  
E Coli ◽  
Recent Emergence ◽  
Tract Infections

ABSTRACTEscherichia coli, an intestinal Gram-negative bacterium, has been shown to be associated with a variety of diseases in addition to intestinal infections, such as urinary tract infections (UTIs), meningitis in neonates, septicemia, skin and soft tissue infections (SSTIs), and colisepticemia. Thus, for nonintestinal infections, it is categorized as extraintestinal pathogenicE. coli(ExPEC). It is also an opportunistic pathogen, causing cross infections, notably as an agent of zoonotic diseases. However, comparative genomic data providing functional and genetic coordinates for ExPEC strains associated with these different types of infections have not proven conclusive. In the study reported here, ExPECE. coliisolated from SSTIs was characterized, including virulence and drug resistance profiles, and compared with isolates from patients suffering either pyelonephritis or septicemia. Results revealed that the majority of the isolates belonged to two pathogenic phylogroups, B2 and D. Approximately 67% of the isolates were multidrug resistant (MDR), with 85% producing extended-spectrum beta-lactamase (ESBL) and 6% producing metallo-beta-lactamase (MBL). TheblaCTX-M-15genotype was observed in at least 70% of theE. coliisolates in each category, conferring resistance to an extended range of beta-lactam antibiotics. Whole-genome sequencing and comparative genomics of the ExPEC isolates revealed that two of the four isolates from SSTIs, NA633 and NA643, belong to pandemic sequence type ST131, whereas functional characteristics of three of the ExPEC pathotypes revealed that they had equal capabilities to form biofilm and were resistant to human serum. Overall, the isolates from a variety of ExPEC infections demonstrated similar resistomes and virulomes and did not display any disease-specific functional or genetic coordinates.IMPORTANCEInfections caused by extraintestinal pathogenicE. coli(ExPEC) are of global concern as they result in significant costs to health care facilities management. The recent emergence of a multidrug-resistant pandemic clone,Escherichia coliST131, is of primary concern as a global threat. In developing countries, such as India, skin and soft tissue infections (SSTIs) associated withE. coliare marginally addressed. In this study, we employed both genomic analysis and phenotypic assays to determine relationships, if any, among the ExPEC pathotypes. Similarity between antibiotic resistance and virulence profiles was observed, ST131 isolates from SSTIs were reported, and genomic similarities among strains isolated from different disease conditions were detected. This study provides functional molecular infection epidemiology insight into SSTI-associatedE. colicompared with ExPEC pathotypes.

scholarly journals Usefulness of procalcitonin (PCT), C-reactive protein (CRP), and white blood cell (WBC) levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections in children

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Yang Li ◽  
Lanfang Min ◽  
Xin Zhang
Keyword(s):  
Differential Diagnosis ◽  
Respiratory Tract ◽  
Bacterial Infection ◽  
Bacterial Infections ◽  
Respiratory Tract Infections ◽  
Respiratory Infections ◽  
Diagnostic Value ◽  
Significant Difference ◽  
Group A ◽  
Tract Infections

Abstract Background There is a lack of studies comparing PCT, CRP and WBC levels in the differential diagnosis of acute bacterial, viral, and mycoplasmal respiratory tract infections. It is necessary to explore the correlation between above markers and different types of ARTI. Methods 108 children with confirmed bacterial infection were regarded as group A, 116 children with virus infection were regarded as group B, and 122 children with mycoplasmal infection were regarded as group C. The levels of PCT, CRP and WBC of the three groups were detected and compared. Results The levels of PCT, CRP and WBC in group A were significantly higher than those in groups B and C (p < 0.05). The positive rate of combined detection of PCT, CRP and WBC was significant higher than that of single detection. There was no significant difference in PCT, CRP and WBC levels between the group of G+ bacterial infection and G− bacterial infection (p > 0.05). ROC curve results showed that the AUC of PCT, CRP and WBC for the diagnosis of bacterial respiratory infections were 0.65, 0.55, and 0.58, respectively. Conclusions PCT, CRP and WBC can be combined as effective indicators for the identification of acute bacterial or no-bacterial infections in children. The levels of PCT and CRP have higher differential diagnostic value than that of WBC in infection, and the combined examination of the three is more valuable in clinic.

Sign in / Sign up

Export Citation Format

Share Document