scholarly journals Hepathoprotective and dezintoxictional effect of medicine «Hamavit» and «Fospreniol» under direct and administrative application in the poultry

2018 ◽  
Vol 20 (83) ◽  
pp. 420-424
Author(s):  
M. Nenchuk
Keyword(s):  
Uric Acid ◽  
Detrimental Effect ◽  
Cost Effective ◽  
Negative Effects ◽  
The Third ◽  
Complete Restoration ◽  
Combined Use ◽  
Experimental Bird ◽  
Increased Activity ◽  
Endogenous Stages

Changes in the biochemical composition of blood among hens during experimental eimeriosis reflect the development of pathological processes in their bodies. Taking into account that eimeria affect not only the epithelial cells of the intestinal mucosa, but cause deep morphofunctional changes in the liver, we have studied the protein synthesis and detoxification properties of the chickens during the experimental eimeriosis. To solve the problems, the study was conducted on the chickens, which, by analogy, were divided into 6 groups: control (K) and 5 experimental (D1–D5) with 8 chickens in each. At the beginning of the experiment their age was 4 weeks. They were fed by the mixed fodder. Accordingly, experimental chickens from the first to fifth experimental groups were infected by Eimerioid invasion. At the same time, the experimental bird of the 1st group (D1) was not processed by the eimiriocidal agent, and for the following four (D2–D5) as a parasitic agent, a new remedy Brovafom new was given, which was prescribed 2 g per kg of the mixed fodder feed during 7 days. In addition, in order to ensure the rapid recovery of the poultry organism after an application of the antiparasitic remedy, chickens from the third (D3) and fourth (D4) experimental groups were given Gamavit and Fosprenil during 7 days in doses of 2.5 ml per 1 liter of water. We have found out that in the serum of blood of chickens from the experimental groups a low level of total protein and especially its protein fraction was presented. In addition, the concentration of uric acid and creatinine increased in the poultry blood and increased activity of AlAT and AsAT. The most effective and cost-effective methods of combating eimeriosis is the use of chemical drugs that delay or detrimental effect on the eimeria (eimeriosis) effects at the endogenous stages of development. After the application of the therapeutic purpose of the eimeriostatic remedy «Brovaf new» eliminates the negative effects of toxins on hepatocytes of the liver. It is noted that complete restoration of the functional state of the liver is not achieved. Rather and more efficiently, this process takes place during the bird products with medicine Gamavit and Fosprenil, with the best result and with a lower dose achieved through their combined use

scholarly journals Cost-effectiveness of a hybrid emergency room system for severe trauma: a health technology assessment from the perspective of the third-party payer in Japan

2021 ◽  
Vol 16 (1) ◽  
Author(s):  
Takahiro Kinoshita ◽  
Kensuke Moriwaki ◽  
Nao Hanaki ◽  
Tetsuhisa Kitamura ◽  
Kazuma Yamakawa ◽  
...  
Keyword(s):  
Cost Effectiveness ◽  
Emergency Room ◽  
Healthcare Costs ◽  
Cost Effective ◽  
Severe Trauma ◽  
Third Party ◽  
Trauma Patients ◽  
Short Term ◽  
The Third

Abstract Background Hybrid emergency room (ER) systems, consisting of an angiography-computed tomography (CT) machine in a trauma resuscitation room, are reported to be effective for reducing death from exsanguination in trauma patients. We aimed to investigate the cost-effectiveness of a hybrid ER system in severe trauma patients without severe traumatic brain injury (TBI). Methods We conducted a cost-utility analysis comparing the hybrid ER system to the conventional ER system from the perspective of the third-party healthcare payer in Japan. A short-term decision tree and a long-term Markov model using a lifetime time horizon were constructed to estimate quality-adjusted life years (QALYs) and associated lifetime healthcare costs. Short-term mortality and healthcare costs were derived from medical records and claims data in a tertiary care hospital with a hybrid ER. Long-term mortality and utilities were extrapolated from the literature. The willingness-to-pay threshold was set at $47,619 per QALY gained and the discount rate was 2%. Deterministic and probabilistic sensitivity analyses were conducted. Results The hybrid ER system was associated with a gain of 1.03 QALYs and an increment of $33,591 lifetime costs compared to the conventional ER system, resulting in an ICER of $32,522 per QALY gained. The ICER was lower than the willingness-to-pay threshold if the odds ratio of 28-day mortality was < 0.66. Probabilistic sensitivity analysis indicated that the hybrid ER system was cost-effective with a 79.3% probability. Conclusion The present study suggested that the hybrid ER system is a likely cost-effective strategy for treating severe trauma patients without severe TBI.

scholarly journals Causes of Regionalism. How ASEAN-China FTA Fits the (New) Wave of Regionalism?

2017 ◽  
Vol 17 (1) ◽  
pp. 66-94
Author(s):  
Ivana Miková
Keyword(s):  
Common Mechanism ◽  
Third Wave ◽  
New Wave ◽  
Negative Effects ◽  
Regional Trade ◽  
Multilateral Trade ◽  
The Third ◽  
Alternative Approach ◽  
General Logic ◽  
Balance Mechanism

AbstractThe main aim of this paper is to discuss standard explanations of the causes respective to each wave of economic regionalism and to introduce an alternative approach suggesting the existence of a common mechanism driving all three periods of intensified economic integration. This study argues for the general logic to economic regionalism based on the balance mechanism. Proposed mechanism embraces standard theoretical explanations and places them into a broader context of general encompassing logic common to all three occurrences of economic regionalism. For acquiring empirical evidence of this mechanism, all three waves of regionalism and their causes are analysed as well as on one particular case of the third wave of regionalism - ASEAN-China FTA. Central motivation is the existence of plethora of factors leading to the preference of the regional trade strategies in particular time periods without offering explanation common to all three main occurrences of regionalism. However, this study argues that every instance of economic turmoil leads to protectionist tendencies in the form of economic regionalism followed by the multilateral trade liberalisation mitigating negative effects of protectionist tendencies.

Review of the impact Covid-19 has on the Psychosocial factors affecting Well-Being

2021 ◽  
pp. 3404-3408
Author(s):  
Sheila Menon FBSCH ◽  
Vidya Bhagat
Keyword(s):  
Psychosocial Factors ◽  
Health Workers ◽  
Public Awareness ◽  
Cost Effective ◽  
Well Being ◽  
Security Measures ◽  
Post Traumatic Stress ◽  
Negative Effects ◽  
Factors Affecting ◽  
The Impact

The COVID-19 pandemic has had a significant impact on the psychosocial factors that effect people globally. Particularly affected are children, students and health workers and the common symptoms identified are stress, anxiety disorders, depression and post-traumatic stress disorder. In addition, the various security measures implemented to ensure public safety have adversely affected relationships between people. This study directs public awareness to the value of psychotherapeutic support. Tele-therapy can be offered easily to people both at home or in the workplace, providing both cost effective and time sensitive solutions during times of crisis. The current review article provides an overview of the importance of maintaining psychological well-being during a pandemic and the identifies the role that empathetic communication has on wellbeing. The literature review was completed using electronic databases such as PubMed, Medline, and Scopus databases using the keywords covid-19, affected groups, affected relationships, psychology and its technological interventions, negative effects of pandemic so on.

scholarly journals Phytoremediation of Toxic Metals: A Sustainable Green Solution for Clean Environment

2021 ◽  
Vol 11 (21) ◽  
pp. 10348
Author(s):  
S. M. Omar Faruque Babu ◽  
M. Belal Hossain ◽  
M. Safiur Rahman ◽  
Moshiur Rahman ◽  
A. S. Shafiuddin Ahmed ◽  
...  
Keyword(s):  
Aquatic Ecosystems ◽  
Extended Period ◽  
Cost Effective ◽  
The Body ◽  
Species Selection ◽  
Environmentally Benign ◽  
Soil Parameters ◽  
Negative Effects ◽  
Clean Environment ◽  
Green Solution

Contamination of aquatic ecosystems by various sources has become a major worry all over the world. Pollutants can enter the human body through the food chain from aquatic and soil habitats. These pollutants can cause various chronic diseases in humans and mortality if they collect in the body over an extended period. Although the phytoremediation technique cannot completely remove harmful materials, it is an environmentally benign, cost-effective, and natural process that has no negative effects on the environment. The main types of phytoremediation, their mechanisms, and strategies to raise the remediation rate and the use of genetically altered plants, phytoremediation plant prospects, economics, and usable plants are reviewed in this review. Several factors influence the phytoremediation process, including types of contaminants, pollutant characteristics, and plant species selection, climate considerations, flooding and aging, the effect of salt, soil parameters, and redox potential. Phytoremediation’s environmental and economic efficiency, use, and relevance are depicted in our work. Multiple recent breakthroughs in phytoremediation technologies are also mentioned in this review.

scholarly journals The influence of cetane-detergent additives into diesel fuel increased to 10% (V/V) of RME content on energy parameters and exhaust gas composition of a diesel engine

2019 ◽  
Vol 179 (4) ◽  
pp. 204-209
Author(s):  
Winicjusz STANIK ◽  
Jerzy CISEK
Keyword(s):  
Diesel Fuel ◽  
Cetane Number ◽  
The Other ◽  
Exhaust Gas ◽  
Gas Composition ◽  
Slight Effect ◽  
Negative Effects ◽  
Exhaust Gases ◽  
The Third ◽  
Reduction Of Nox

To avoid the negative effects of increasing the amount of RME in the diesel fuel (to 10%), three different additive packages were used: stabilising, cleaning, and increasing the cetane number with different concentrations. The tests were carried out using a 4-cylinder, turbocharged 1.9 TDI engine from VW. The tests were carried out for 4 fuels (comparative fuel with a content of 7% RME and 3 test fuels with a content of 10% RME, differing in the content of the additive package.It was found that each of the 3 additive packages used does not have a significant impact on fuel consumption. However, a different effect of the tested additives on the composition of exhaust gases was observed. The first package had a slight effect on reducing the NOx concentration in the exhaust, but only for small engine loads. On the other hand, the second additive pack worked more effectively only at higher engine loads (in relation to the reduction of NOx concentration in the exhaust gases). In the third packet, the amount of the cetane additive was doubled (compared to the second packet). Then, the reduction in the NOx concentration in the exhaust gas by 3–8% was obtained with reference to the comparative fuel.

scholarly journals COMPREHENSIVE PROGRAM AGAINST EXOAND ENDOGENOUS STAGES OF COCCIDIA IN PIG

2020 ◽  
pp. 346-352
Author(s):  
Rinat Safiullin
Keyword(s):  
Sodium Hydroxide Solution ◽  
Physiological Solution ◽  
The Body ◽  
Recommended Dose ◽  
Definite Effect ◽  
Combined Use ◽  
Negative Effect ◽  
Complex Preparation ◽  
Biological Protection ◽  
Endogenous Stages

Coccidiosis (isosporiasis, eimeriosis) and balantidiasis are most common among endamebas, which affect pigs of different age but they have the greatest negative effect on young animals. The work was carried out in a sow house at a pig complex in the Moscow Region. The sow house was divided into four sectors with 40 sows each. Complex preparation Kenocox 4% and Emeriocide 5% at a recommended dose and exposure were used for disinfestation during the preparation of the sow house in sectors 1 and 2. The recommended dose of 4% hot sodium hydroxide solution (basic version) was used for disinvasion of sectors 3 and 4. Piglets were taken from the mother at the age of 23 days at this farm. Piglets from sectors 1 and 2 were prescribed Toltrazuril 5% at a dose of the active substance of 30 mg / kg of the body weight after farrowing on the 3rd to 5th days of age as a preventive course. Piglets from sectors 3 and 4 served as a control and were prescribed physiological solution at a single dose of 1 ml orally. The combined use of drugs against the exogenous and endogenous stages of Coccidia significantly improved the level of biological protection of the sow house, which had a definite effect on production and economic results.

scholarly journals Aquatic Macroinvertebrate Assemblages in Rivers Under the Influence of Mining Activities

2021 ◽  
Author(s):  
Axel Eduardo Rico-Sánchez ◽  
Alexis Joseph Rodríguez-Romero ◽  
Jacinto Elías Sedeño-Díaz ◽  
Eugenia López-López ◽  
Andrea Sundermann
Keyword(s):  
Heavy Metals ◽  
Structural Changes ◽  
Cost Effective ◽  
Diversity Indices ◽  
Aquatic Macroinvertebrates ◽  
Conservation Strategies ◽  
Mining Activities ◽  
Macroinvertebrate Communities ◽  
Negative Effects ◽  
Central Plateau

Abstract Mining is one of the main pollution issues worldwide, causing the greatest disturbances to the environment. Industrial and artisanal mining activities are widespread in Mexico, being a major global producer of various metals. This study aimed to assess the ecological impairments resulting from mining activities using the aquatic macroinvertebrates assemblages (MA). A multiple co-inertia analysis (MCOA) was applied to determine the relationships between environmental factors, habitat quality, heavy metals, and aquatic macroinvertebrates in two rivers of the Central Plateau, Mexico. The results revealed three contrasting environmental conditions and different MA. High concentrations of heavy metals, nutrients, and salinity limit the presence of various families of seemingly sensitive macroinvertebrates, these factors were identified as the drivers of structural changes in the MA, showing that not only mining activities, but also agriculture, and villages in the basin, exert negative effects to the macroinvertebrate communities. Diversity indices showed that the lowest diversity matched with both, the most polluted and the most saline rivers. The rivers studied displayed a high alkalinity and hardness, which can lead to the formation of metal precipitates and thus acting as a protection to aquatic biota. Aquatic biomonitoring in rivers, impacted by mining and other human activities, is critical for detecting the effect of metals and other pollutants to improve management and conservation strategies. This study supports the design of cost-effective and accurate water quality biomonitoring protocols in developing countries.

scholarly journals Detection of Bactrocera oleae (Diptera: Tephritidae) DNA in the gut of the soil species Pseudoophonus rufipes (Coleoptera: Carabidae)

2018 ◽  
Vol 16 (3) ◽  
pp. e1007
Author(s):  
Alice Albertini ◽  
Sónia A. P. Santos ◽  
Fátima Martins ◽  
José A. Pereira ◽  
Teresa Lino-Neto ◽  
...  
Keyword(s):  
Control Strategies ◽  
Cost Effective ◽  
Olive Tree ◽  
Carabid Beetles ◽  
Bactrocera Oleae ◽  
Negative Effects ◽  
Cytochrome Oxidase Subunit ◽  
Mtdna Sequences ◽  
Olive Orchard ◽  
Control Service

Pest control service provided by natural enemies of Bactrocera oleae, the key pest of the olive tree, is nowadays recognized as fundamental. B. oleae has developed resistance to common insecticides, and negative effects both on consumers’ health and non-target species are the major drawbacks of conventional control strategies. Carabid beetles are potential B. oleae pupae predators, but their predation on field still need to be assessed. We tested adult Pseudoophonus rufipes, a species known to be active in olive orchard when pest pupae are abundant in the soil, in order to detect B. oleae pupae consumption at different post feeding times for both male and female carabids. An already existing protocol was used for detecting B. oleae mtDNA sequences of the cytochrome oxidase subunit I gene in carabids’ gut, and its versatility improved. B. oleae mtDNA was detected up to 20 h after pupa ingestion with a high percentage of success, without significant differences between sexes and pair primers used. Prey DNA extraction was tested from both dissected and non-dissected carabids, obtaining comparable results. The trapping system used to collect carabids for molecular assays and the new elements introduced in the protocol represent cost-effective solutions that may be beneficial for future laboratory trials and, mostly, for the analysis of field-collected predators. Fostering the investigation of soil predators in olive orchard may increase the design of conservation control strategies against B. oleae.

scholarly journals Using molecular testing and whole-genome sequencing for tuberculosis diagnosis in a low-burden setting: a cost-effectiveness analysis using transmission-dynamic modelling

Thorax ◽  
2021 ◽  
Vol 76 (3) ◽  
pp. 281-291 ◽  
Author(s):  
Tendai Mugwagwa ◽  
Ibrahim Abubakar ◽  
Peter J White
Keyword(s):  
Cost Effectiveness ◽  
Whole Genome Sequencing ◽  
Genome Sequencing ◽  
Drug Sensitivity ◽  
Cost Effective ◽  
Molecular Testing ◽  
Whole Genome ◽  
Transmission Dynamic ◽  
Sensitivity Testing ◽  
Combined Use

BackgroundDespite progress in TB control in low-burden countries like England and Wales, there are still diagnostic delays. Molecular testing and/or whole-genome sequencing (WGS) provide more rapid diagnosis but their cost-effectiveness is relatively unexplored in low-burden settings.MethodsAn integrated transmission-dynamic health economic model is used to assess the cost-effectiveness of using WGS to replace culture-based drug-sensitivity testing, versus using molecular testing versus combined use of WGS and molecular testing, for routine TB diagnosis. The model accounts for the effects of faster appropriate treatment in reducing transmission, benefiting health and reducing future treatment costs. Cost-effectiveness is assessed using incremental net benefit (INB) over a 10-year horizon with a quality-adjusted life-year valued at £20 000, and discounting at 3.5% per year.ResultsWGS shortens the time to drug sensitivity testing and treatment modification where necessary, reducing treatment and hospitalisation costs, with an INB of £7.1 million. Molecular testing shortens the time to TB diagnosis and treatment. Initially, this causes an increase in annual costs of treatment, but averting transmissions and future active TB disease subsequently, resulting in cost savings and health benefits to achieve an INB of £8.6 million (GeneXpert MTB/RIF) or £11.1 million (Xpert-Ultra). Combined use of Xpert-Ultra and WGS is the optimal strategy we consider, with an INB of £16.5 million.ConclusionRoutine use of WGS or molecular testing is cost-effective in a low-burden setting, and combined use is the most cost-effective option. Adoption of these technologies can help low-burden countries meet the WHO End TB Strategy milestones, particularly the UK, which still has relatively high TB rates.

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