scholarly journals КЛІНІКО–ГЕМАТОЛОГІЧНІ ПОКАЗНИКИ КОРІВ ПІВНІЧНО–СХІДНОЇ БІОГЕОХІМІЧНОЇ ЗОНИ УКРАЇНИ ЗА РІЗНИХ ПЕРІОДІВ ЛАКТАЦІЇ

2016 ◽  
Vol 18 (3(71)) ◽  
pp. 19-24
Author(s):  
N.G. Grushanska ◽  
V.M. Kostenko
Keyword(s):  
Mineral Metabolism ◽  
Hematological Parameters ◽  
Clinical Signs ◽  
Diagnostic System ◽  
Farm Animals ◽  
Clinical Indicators ◽  
Lactating Cows ◽  
Biochemical Analyzer ◽  
Standard Set ◽  
The Impact

Complicating effect of the adverse technogenic environmental factors that cause changes of biogeocoenose at the interaction with the natural deficiency of biogenic microelements, contributes to appearing and spread of pathology of mineral metabolism in farm animals, particularly in lactating cows. The question about the impact of the northern–eastern biogeochemical zone of Ukraine on the clinical and hematological parameters of cows at lactation’s period is studied insufficiently.The research was conducted in the three farms of Chernihiv region (northern–eastern biogeochemical zone).In the article the materials of our scientific research on determination of the clinical indicators among cows (heart rate, respiratory rate) are represented. The experimental diagnostic system is built on the principle: the sensor – amplifier – generator USW – modulator frequencies – antenna transmitter – receiver antenna – receiver – the computer. Blood was tested on the biochemical analyzer «Labline – 010» with standard set of reagents and the keeping conditions and ration of feeding cows were analized according to conventional methods.The benefits of remote diagnostic device for clinical signs of cows by researcher’s saving time on 37.5% are established. The clinical indicators and main indicators of metabolism among cows of the northern–eastern biogeochemical zones in the 8 – 15, 55 – 65, 150 – 170 day of lactation and 55 – 60 days befor calving are investigated.

scholarly journals Biochemical and Haematological Blood Parameters at Different Stages of Lactation in Cows

2017 ◽  
Vol 74 (1) ◽  
pp. 31 ◽  
Author(s):  
Cristian Ovidiu COROIAN ◽  
Vioara MIRESAN ◽  
Aurelia COROIAN ◽  
Camelia RADUCU ◽  
Luisa ANDRONIE ◽  
...  
Keyword(s):  
Dairy Cows ◽  
Biochemical Parameters ◽  
Post Partum ◽  
Hematological Parameters ◽  
Technological Factor ◽  
Clinical Signs ◽  
Blood Parameters ◽  
Holstein Breed ◽  
Lactating Cows ◽  
Blood Biochemical

The health status of cows is evaluated and depending on haematological and biochemical profile of blood. Nutrition is the main technological factor that can produce profound changes in the metabolic profile in animals (Dhiman et al., 1991; Khaled et al., 1999; Ingvartsen, 2006). Blood parameters analyze can lead to identify if there are errors in nutrition of lactating cows (Payne et al., 1970). The aim of this study was the evaluation of metabolic and biochemical changes that occur during colostrum period and in terms of number of lactations in cows. The biological material was represented by a total of 60 heads of dairy cows from a family farm from Sălaj County, Romania. The cows are all from Holstein breed and presented no clinical signs of any specific pathology. Blood samples were collected from the jugular vein of each cow and analyzed. 10 individuals from each of the six lactations have been randomly selected. Haematological and biochemical parameters showed variations depending on factors analyzed here. In lactation 1 Hb was 7.55±3.05 (g/dl), while in lactation 6 the value was 12.5±2.10 (g/dl). RBC ranged as follows: in lactation 1 - 28.50±2.05 and in lactation 6 - 30.02±2.05. Lymphocytes varied within very wide limits under the influence of lactation: in lactation 1 - 2.8±1.56 and in lactation 6 - 7.55±1.80. The number of lactations and lactation rank have influenced blood biochemical and hematological parameters in dairy cows. Biochemical parameters are influenced by post-partum day, showing the lowest values in the early days of colostral period and the highest in the last few days of the same period.

scholarly journals Milk quality indicators, productivity in cows and changes in blood composition when feeding mineral supplements

2021 ◽  
Vol 344 (1) ◽  
pp. 26-29
Author(s):  
E. A. Mitsurina ◽  
L. N. Gamko
Keyword(s):  
Dry Matter ◽  
Positive Impact ◽  
Mineral Metabolism ◽  
Hematological Parameters ◽  
The Body ◽  
Biologically Active ◽  
Mineral Supplements ◽  
Lactating Cows ◽  
Experimental Group ◽  
Active Substances

Relevance. This article shows the influence of the same doses of natural mineral supplements "Stimul" and smectite trepel, their positive impact on increasing productivity, as well as changes in the hematological parameters of the blood of lactating cows.Results. Feeding natural zeolites provided the need for biologically active substances and improvement of individual indicators of dairy products.The mass fraction of fat in the 1st experimental group was 0.1% higher, and the amount of protein was in the range of 2.9–3.1%. At the same time, it should be noted that the most stimulating effect on mineral metabolism in the body of lactating cows with the same composition of rations was better used in the mineral part of the diet was better used, which included 3.0% smekty trepel from dry matter.

Influence of DAFS-25+polizon composition on blood and functional state of liver of steers at fattening

2020 ◽  
pp. 15-18
Author(s):  
Inna R. Kilmetova ◽  
◽  
Igor A. Rodin ◽  
Nazira I. Khayrullina ◽  
Nikolay G. Fenchenko ◽  
...  
Keyword(s):  
Functional State ◽  
White Blood Cells ◽  
Live Weight ◽  
The Body ◽  
Farm Animals ◽  
Control Group ◽  
Standard Diet ◽  
The Impact ◽  
Experimental Group ◽  
Stimulation Of

Summary. The disbalanced feeding and the uneven distribution of micro- and macroelements in the environment leads to a trace element, in particular hypomelanosis. To accelerate the growth and preservation of young farm animals include in the diet of various biological additives and drugs, which include selenium. For stimulation of weight gain in the livestock industry, as well as for the prevention and treatment of pathological processes in addition to micro - and macrouse amino acids, primarily methionine. The aim of this work was to study the influence of composition of DAFS-25+Polizon on morpho-biochemical parameters of blood and functional state of the liver in fattening bulls of black-motley breed in the conditions of the Republic of Bashkortostan. Experiments using were conducted on bull-calves of black-motley breed of the properties in the properties age from 6 to 15 months. The first experimental group during the experiment was additionally given the composition of DAFS-25+Polizon at a dose of 2 mg/kg, the animals of the control group received a standard diet. To assess the impact of the composition DAFS-25+Polizon on metabolism cattle studied morphological and biochemical indicators of blood and conducted histological examination of the liver. It is established that the use of the composition of DAFS-25+Polizon at a dose of 2 mg/kg increases the number of erythrocytes and hemoglobin in the experimental group and reduces the amount of white blood cells. The serum content of total protein, phosphorus and calcium increases in the group of experimental animals. Microscopic examination of the liver revealed no changes in the structure of the organ and hepatocytes in the experimental group, whereas in the control group hemodynamic disorders and dystrophic changes in liver cells were observed. Thus, the use of the composition DAFS-25+Polizon at a dose of 2 mg/kg of live weight in fattening bulls black-and-white breed contributes to the increase of redox processes in the body, stimulation of metabolism, prevent the development of liver disorders of cellular mechanisms of metabolism, optimizes the structure of the liver, which generally provides higher productivity.

Extruded lupine as a part of energy-protein concentrate in the ration of lactating cows

2020 ◽  
pp. 65-73
Author(s):  
Z. Fedorova
Keyword(s):  
Farm Animals ◽  
Feed Consumption ◽  
Control Group ◽  
Protein Concentrate ◽  
Cattle Farm ◽  
Black And White ◽  
Lactating Cows ◽  
White Breed ◽  
Kaliningrad Region ◽  
Experimental Group

In order to fi ll the existing protein defi ciency in the rations of farm animals in particular dairy cows it is necessary to input feed lupins as widely as possible in crop rotations. Lupin is a very versatile forage crop it can be used in feed as herbage, in the form of haylage, silage, in compound feed as a protein additive, as well as a green manure crop to increase soil fertility. Questions of protein nutrition should be to be quickly resolved, both in the production of protein and in its standardized rational use. Unbalanced protein rations increase feed consumption per unit of production, thereby increasing its prime cost. In the world soya is generally recognized as a protein feed, but in the Kaliningrad region as in most of regions in our country, it does not maturate being a heat-loving crop. Under these environments the inclusion of extruded lupine grain in the composition of energy-protein concentrates for the production of compound feed has become an alternative to replacing expensive soya. The researches have been carried out it the cattle farm of LLC “Temp” in the Guryevsky area in the Kaliningrad region (March-May 2019) on feeding lactating cows energy-protein concentrate from extruded grain of narrow-leaved lupine, fl ax, triticale, subjected to heat treatment on a press extruder. For this purpose two groups of lactating cows of Black-and-White breed (control and experimental) have been formed using the method of pairs of analogs per 11 heads in each. Cows of the control group have received the main ration of the farm, and cows of the experimental group in addition to the main ration have received compound feed with extruded energy-protein concentrate based on lupine. As a result of research, the positive infl uence of energy-protein concentrate based on lupine in compound feed on the dairy productivity of cows has been established. Recipes of concentrate and compound feed with concentrate for lactating cows, the volume of inclusion of components in the concentrate and in the compound feed have been calculated. During the experiment, the milk yield in the experimental group of cows has increased by 62,4 kg or 8,0 %, than in the control group. From the cows of the experimental group the conditional profi t has been received in the amount of 1684,8 rubles per head.

Effects of Food Protein Levels on Haematological Parameters of Growing Japanese Quails (Coturnix Coturnix Japonica Temminck & Schlegel, 1849)

2020 ◽  
Vol 6 (6) ◽  
pp. 94-100
Author(s):  
Serge-Olivier Konan KOUASSI ◽  
◽  
Yves Bénarèce Tra DJE BI ◽  
Soualio KAMAGATE ◽  
Mathieu Nahounou BLEYERE ◽  
...  
Keyword(s):  
Crude Protein ◽  
Hematological Parameters ◽  
Coturnix Japonica ◽  
Food Protein ◽  
Coturnix Coturnix Japonica ◽  
Coturnix Coturnix ◽  
Protein Levels ◽  
Dietary Crude Protein ◽  
Japanese Quails ◽  
The Impact

The study aims to determine the impact of dietary crude protein levels on the hematological parameters of Japanese quail from growth to ovipositor. To this end, five feeds with different crude protein levels (18, 20, 22, 24 and 26%) were supplied to 700 quails of three weeks of age. These were subdivided into six batches, including three batches of females and three batches of males for each feed group. After subjecting the quails to diets containing the different protein levels, four samples were taken at the fourth, fifth, sixth and seventh week of age. The samples taken were analyzed using an SYSMEX XN 350 automated hematological analyzer. The results of this investigation indicated that non-significant differences (P > 0.05) were observed in hematological parameters in both female and male quails. This study showed that dietary crude protein levels had no impact on the health status of Japanese quails. Keywords: Japanese quails, Crude protein, Hematological parameters.

scholarly journals Comparison of Selected Immune and Hematological Parameters and Their Impact on Survival in Patients with HPV-Related and HPV-Unrelated Oropharyngeal Cancer

Cancers ◽  
2021 ◽  
Vol 13 (13) ◽  
pp. 3256
Author(s):  
Adam Brewczyński ◽  
Beata Jabłońska ◽  
Agnieszka Maria Mazurek ◽  
Jolanta Mrochem-Kwarciak ◽  
Sławomir Mrowiec ◽  
...  
Keyword(s):  
Prognostic Factors ◽  
Oropharyngeal Cancer ◽  
Hematological Parameters ◽  
White Blood Cells ◽  
Post Treatment ◽  
Neutrophil Lymphocyte Ratio ◽  
Lymphocyte Ratio ◽  
Hpv Status ◽  
Pre Treatment ◽  
The Impact

Several immune and hematological parameters are associated with survival in patients with oropharyngeal cancer (OPC). The aim of the study was to analyze selected immune and hematological parameters of patients with HPV-related (HPV+) and HPV-unrelated (HPV-) OPC, before and after radiotherapy/chemoradiotherapy (RT/CRT) and to assess the impact of these parameters on survival. One hundred twenty seven patients with HPV+ and HPV− OPC, treated with RT alone or concurrent chemoradiotherapy (CRT), were included. Patients were divided according to HPV status. Confirmation of HPV etiology was obtained from FFPE (Formalin-Fixed, Paraffin-Embedded) tissue samples and/or extracellular circulating HPV DNA was determined. The pre-treatment and post-treatment laboratory blood parameters were compared in both groups. The neutrophil/lymphocyte ratio (NLR), platelet/lymphocyte ratio (PLR), monocyte/lymphocyte ratio (MLR), and systemic immune inflammation (SII) index were calculated. The impact of these parameters on overall (OS) and disease-free (DFS) survival was analyzed. In HPV+ patients, a high pre-treatment white blood cells (WBC) count (>8.33 /mm3), NLR (>2.13), SII (>448.60) significantly correlated with reduced OS, whereas high NLR (>2.29), SII (>462.58) significantly correlated with reduced DFS. A higher pre-treatment NLR and SII were significant poor prognostic factors for both OS and DFS in the HPV+ group. These associations were not apparent in HPV− patients. There are different pre-treatment and post-treatment immune and hematological prognostic factors for OS and DFS in HPV+ and HPV− patients. The immune ratios could be considered valuable biomarkers for risk stratification and differentiation for HPV− and HPV+ OPC patients.

scholarly journals SARS-CoV-2/DENV co-infection: a series of cases from the Federal District, Midwestern Brazil

2021 ◽  
Vol 21 (1) ◽  
Author(s):  
Heidi Luise Schulte ◽  
José Diego Brito-Sousa ◽  
Marcus Vinicius Guimarães Lacerda ◽  
Luciana Ansaneli Naves ◽  
Eliana Teles de Gois ◽  
...  
Keyword(s):  
Clinical Signs ◽  
Federal District ◽  
Therapeutic Interventions ◽  
Diagnostic Process ◽  
The Novel ◽  
Prevention Measures ◽  
Laboratory Findings ◽  
Novel Coronavirus ◽  
The Impact

Abstract Background Since the novel coronavirus disease outbreak, over 179.7 million people have been infected by SARS-CoV-2 worldwide, including the population living in dengue-endemic regions, particularly Latin America and Southeast Asia, raising concern about the impact of possible co-infections. Methods Thirteen SARS-CoV-2/DENV co-infection cases reported in Midwestern Brazil between April and September of 2020 are described. Information was gathered from hospital medical records regarding the most relevant clinical and laboratory findings, diagnostic process, therapeutic interventions, together with clinician-assessed outcomes and follow-up. Results Of the 13 cases, seven patients presented Acute Undifferentiated Febrile Syndrome and six had pre-existing co-morbidities, such as diabetes, hypertension and hypopituitarism. Two patients were pregnant. The most common symptoms and clinical signs reported at first evaluation were myalgia, fever and dyspnea. In six cases, the initial diagnosis was dengue fever, which delayed the diagnosis of concomitant infections. The most frequently applied therapeutic interventions were antibiotics and analgesics. In total, four patients were hospitalized. None of them were transferred to the intensive care unit or died. Clinical improvement was verified in all patients after a maximum of 21 days. Conclusions The cases reported here highlight the challenges in differential diagnosis and the importance of considering concomitant infections, especially to improve clinical management and possible prevention measures. Failure to consider a SARS-CoV-2/DENV co-infection may impact both individual and community levels, especially in endemic areas.

scholarly journals A 7-month inhalation toxicology study in C57BL/6 mice demonstrates reduced pulmonary inflammation and emphysematous changes following smoking cessation or switching to e-vapor products

2021 ◽  
Vol 5 ◽  
pp. 239784732199587
Author(s):  
Ashutosh Kumar ◽  
Ulrike Kogel ◽  
Marja Talikka ◽  
Celine Merg ◽  
Emmanuel Guedj ◽  
...  
Keyword(s):  
Smoking Cessation ◽  
Cigarette Smoke ◽  
Pulmonary Inflammation ◽  
Clinical Signs ◽  
Inhalation Study ◽  
Toxicology Study ◽  
Nasal Tissue ◽  
Product Switching ◽  
The Impact

Cigarette smoking causes serious diseases, including lung cancer, atherosclerotic coronary artery disease, peripheral vascular disease, chronic bronchitis, and emphysema. While cessation remains the most effective approach to minimize smoking-related disease, alternative non-combustible tobacco-derived nicotine-containing products may reduce disease risks among those unable or unwilling to quit. E-vapor aerosols typically contain significantly lower levels of smoke-related harmful and potentially harmful constituents; however, health risks of long-term inhalation exposures are unknown. We designed a 7-month inhalation study in C57BL/6 mice to evaluate long-term respiratory toxicity of e-vapor aerosols compared to cigarette smoke and to assess the impact of smoking cessation (Cessation group) or switching to an e-vapor product (Switching group) after 3 months of exposure to 3R4F cigarette smoke (CS). There were no significant changes in in-life observations (body weights, clinical signs) in e-vapor groups compared to the Sham Control. The 3R4F CS group showed reduced respiratory function during exposure and had lower body weight and showed transient signs of distress post-exposure. Following 7 months of exposure, e-vapor aerosols resulted in no or minimal increase in pulmonary inflammation, while exposure to 3R4F CS led to impairment of lung function and caused marked lung inflammation and emphysematous changes. Biological changes observed in the Switching group were similar to the Cessation group. 3R4F CS exposure dysregulated the lung and nasal tissue transcriptome, while these molecular effects were substantially lower in the e-vapor group. Results from this study demonstrate that in comparison with 3R4F CS, e-vapor aerosols induce substantially lower biological responses including pulmonary inflammation and emphysematous changes, and that complete switching from CS to e-vapor products significantly reduces biological changes associated with CS in C57BL/6 mice.

scholarly journals Effect of Chronic Administration of 5-(3-chlorophenyl)-4-Hexyl-2,4 -Dihydro-3H-1,2,4-Triazole-3-Thione (TP-315)—A New Anticonvulsant Drug Candidate—On Living Organisms

2021 ◽  
Vol 22 (7) ◽  
pp. 3358
Author(s):  
Anna Makuch-Kocka ◽  
Marta Andres-Mach ◽  
Mirosław Zagaja ◽  
Anna Śmiech ◽  
Magdalena Pizoń ◽  
...  
Keyword(s):  
Hematological Parameters ◽  
Anticonvulsant Drug ◽  
Living Organism ◽  
Drug Candidate ◽  
In Vitro Tests ◽  
Maximal Electroshock ◽  
Tp 315 ◽  
The Impact ◽  
Chronic Use

About 70 million people suffer from epilepsy—a chronic neurodegenerative disease. In most cases, the cause of the disease is unknown, but epilepsy can also develop as the result of a stroke, trauma to the brain, or the use of psychotropic substances. The treatment of epilepsy is mainly based on the administration of anticonvulsants, which the patient must most often use throughout their life. Despite significant progress in research on antiepileptic drugs, about 30% of patients still have drug-resistant epilepsy, which is insensitive to pharmacotherapy used so far. In our recent studies, we have shown that 4-alkyl-5-aryl-1,2,4-triazole-3-thiones act on the voltage-gated sodium channels and exhibit anticonvulsant activity in an MES (maximal electroshock-induced seizure) and 6Hz test in mice. Previous studies have shown their beneficial toxic and pharmacological profile, but their effect on a living organism during chronic use is still unknown. In the presented study, on the basis of the previously conducted tests and the PAMPA (parallel artificial membrane permeability assay) BBB (blood–brain barrier) test, we selected one 1,2,4-triazole-3-thione derivative—TP-315—for further studies aimed at assessing the impact of its chronic use on a living organism. After long-term administration of TP-315 to Albino Swiss mice, its effect on the functional parameters of internal organs was assessed by performing biochemical, morphological, and histopathological examinations. It was also determined whether the tested compound inhibits selected isoforms of the CYP450 enzyme system. On the basis of the conducted tests, it was found that TP-315 does not show nephrotoxic nor hepatotoxic effects and does not cause changes in hematological parameters. In vitro tests showed that TP-315 did not inhibit CYP2B6, CYP2D6, CYP3A4, or CYP3A5 enzymes at the concentration found in the serum of mice subjected to long-term exposure to this compound.

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